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NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.

通过研究,我们提出了初步的NodD操纵子激活模型:第一,四聚体是NodD蛋白的功能单位,它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子;第二,小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体,在我们的模型中,NodD四聚体缩小其V形主体的弯折角,进而缩短其DNA结合功能域的间距;第三,小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用,NodD的构象改变由蛋白质经其双铆钉位点传递给DNA;第四,只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物;第五,不排除NodD与RNA聚合酶可能有直接的相互接触位点,不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物,但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。

This Council was held in Constantinople (aka in Trullo , literally,'under the dome' because of the building used) It was convened due to the lack of canons from Fifth and Sixth Ecumenical Councils, Called by Emperor to promulgate canons necessary to correct issues still outstanding from the previous Councils.

本会召开了君士坦丁堡(又名在trullo ,从字面上来看,'圆顶下',因为该大厦的使用),它是召集由于缺乏大炮,从第五次和第六次全基督教议会,所谓由皇帝颁布炮,有必要纠正问题尚待完成,由以前的议会。

The third part does quantitative and qualitative analysis with the questionnaire and visitatorial materials of individual.

依据上述理论基础和第四章的调查结果分析,第五章章提出了建立高校教师激励机制的思路和一些具体建议。

In order to extending the bandwidth of a GNRD coupler, unsymmetric coupled GNRD waveguides is proposed.

第五章根据第四章的理论结果,分析设计了带有弯曲过渡段的GNRD波导定向耦合器。

It's only the fourth or fifth time I've bailed out his band because of him.

它只是我因为他已经援助他的乐团第四的或第五次。

The second part of the thesis disserts the status of regulation mechanism of China 's city 4 water business, existing problems and the reasons, and the present different reform ways, and then suggests integrating water business.

第四章将联系实际工作,通过案例分析,对南京市城市水务一体化改革提出方案和建议。第五章是联系中国加入世界贸易组织,分析&洋水务&到来对一体化的冲击以及我们的对策。

Now the person who was five back of me beginning the day, David, was a person to think about after the tenth hole, because he eagled that hole.

在比赛开始时落后我五杆,位于第三的那位选手在第十洞抓了一只老鹰后开始引起了我的注意。

The second part of the dissertation, chapter 4 and chapter 5, expounds the application of law of electronic commerce.

文章第二部分即第四章和第五章讨论的是电子商务的法律适用问题。

Another essential principle which runs through Plotinus\' theory of soul and his whole philosophy is the idea of "the great chain of beings", i.e. the lower being depends on the higher one, the product is lower than and exists in its producer. The top of this chain is the One or the Good, all things come from and also try to return to him. Hence, returning to the One is the ultimate end of soul. And, this ability is deep in all souls. Because soul is a substance which has many different levels and abilities, the One and Intellect are all present in every soul. Each of our soul all has some divinity by which we can ascend to and achieve the ultimate mystic uniting. So, ascending and uniting is actually a process of returning, i.e. returning deeply to soul and self where the divine hypostases are always shining and illuminating.In order to express these main points, in the part of introduction, I will introduce the character of Plotinus\' time and his individual personality, I will present the reason why I choose

为表达上述要旨,本论文将在导言中介绍普罗提诺所处的时代特征及其个人气质,并交待本文的选题缘起及其基本思路;在第一章中,我们将首先探求灵魂一词的基本含义,然后对普罗提诺之前的希腊哲学史中的灵魂理论做一纵向的爬梳,再给出普罗提诺对此的评论和总结;在第二章中,我们将横向地分析普罗提诺对灵魂的诸多界定,包括灵魂的地位、灵魂的本质与力量、灵魂的层次与构成和灵魂的存在状态四个方面;第三章的主旨是灵魂创生世界,包括灵魂必然下降、灵魂与世界、与身体及其与自我之间的关系;第四章要谈到灵魂建构知识的问题,分感知、记忆、推理与理智三小节;第五章的标题是灵魂追求太一,包括存在大链、灵魂的上升之旅、灵魂的自由与幸福三部分;最后我们将以普罗提诺的神秘主义作为本文的结束语。

If the overall contractor jobbed out to subcontractors, the overall contractor should assume responsibility with subcontractors for the quality of projects under subcontracts.

第五十五条建筑工程实行总承包的,工程质量由工程总承包单位负责,总承包单位将建筑工程分包给其他单位的,应当对分包工程的质量与分包单位承担连带责任。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。