第二因子

PARTⅡCharacteristic of MMP-9 Activation in Microglia and itsCytokines Secretion after HSV-1 infectedObjective: To investigate the characteristic of MMP-9 activation in microglia and itscytokines secretion.Methods: Balb/c mice were injected intracerebrally with herpes simplex virus type 1(HSV-1) to form herpes simplex encephalitis.

第二部分HSV-1感染小胶质细胞后MMP-9及炎性因子分泌特点研究目的：研究单纯疱疹病毒(HSV-1)感染小胶质细胞系BV2后炎性因子的表达特点，探讨BV2细胞可否作为小鼠单纯疱疹病毒性脑炎模型的替代研究对象。

If the pattern has a low rate of convergence, the time of the human and machines will be wasted and the answer are not surely attainable.So,we must look for the patterns with the high rate of convergence or try to settle some parameters of the iteration patterns (for instance the overrelaxation parameter of SOR iterative method).

本文第二章针对AOR迭代法考察了当线性方程组的系数矩阵A为(1，1)相容次序矩阵且其Jacobi特征值为纯虚数或零时的迭代收敛范围，最优参数(即最优松弛因子和最优加速因子)及与之相应的谱半径，并将此最优谱半径与相应的SOR的进行比较，定量的给出在不同条件下，AOR和SOR迭代法各有其优越性，从而圆满的解决了在这两种迭代法之间如何适当的选择最佳迭代法的问题。

We humans were vehicles for the first replicator and copying machinery for the second.

人类是第一复制因子的运输工具，是第二复制因子的复制机器。

The study period is from 1998 to 2007. The study targets are the ex-dividend events of the all IC firms in Taiwan stock market. After eliminating the samples with incomplete data and disagreement, the sum of samples is 318 ex-dividend events of the 80 firms.

其结构共分为三个面向，第一为探讨产业整体的除权行情，包括全体样本的分析以及历时性的趋势分析；第二为产业上中下游的次产业分类，探讨其除权行情是否有所异同；第三为除权行情的影响因子分析，包含产业景气、盈余成长率、股东配股率、员工配股率、股价净值比、权值股/非权值股共计六个因子。

We introduce some concepts, such as yon Neumann algebras, factor von Neumann algebras, nest algebras and so on, and give some well-known theorems that we will use in this paper. In Chapter 2, we put our attention on linear maps that preserving zero Jordan triple product on nest subalgebrasof factor yon Neumann algebras.

第二章首先对因子von Neumann代数中套子代数上保Jordan三重零积的线性映射进行了研究，证明了从因子von Neumann代数中套子代数到任一有单位元的Banach代数的保Jordan三重零积的单位线性双射是Jordan同构。

PART 2:The molecular mechanisms of Nontypeable Haemophilus influenzae induced inflammatory response in respiratory epithelial cells Objective:Nontypeable Haemophilus influenzaewas traditionally considered as an extracellular pathogen in respiratory infections.In this study,we established a model of infected cells to confirm NTHI was also a facultatively intracellular pathogen.Mitogen activated protein kinasesare the important signal transduction pathway in mediating inflammatory response induced by NTHI in respiratory epithelium.In this study,we elucidate the impact of NTHI,and its SCF and EP on the expression of MAPK and subsequent proinflammatory mediators.

第二部分：NTHI致呼吸道上皮细胞炎症反应的分子机制研究目的：通过建立呼吸道上皮细胞株的体外NTHI感染模型，确认NTHI在细胞内的存活，观察NTHI及其组分(可溶性胞质成分SCF、外膜蛋白EP)对呼吸道上皮细胞MAPK信号传导通路和后续的前炎症因子表达的影响，并应用特异性ERK-MAPK抑制剂U0126、p38 MAPK抑制剂SB203580特异性阻断下游MAPK信号传导通路，观察它们对呼吸道上皮细胞分泌前炎症因子表达的影响。

Autosomal dominant polycystic kidney disease , one of the most common monogenetic human disorders, is characterized by the formation and progressive expansion of multiple cystic lesions, which compromise the function of normal renal parenchyma and lead to nearly 10％ of cases of end-stage renal failure in adults.

中文题名角质细胞生长因子在ADPKD肾囊肿组织中的表达及对囊肿衬里上皮细胞增殖作用的研究副题名外文题名 Expression of keratinocyte growth factor in ADPKD cystic tissue and effect of proliferation on ADPKD cyst-lining epitheliar cells 论文作者刘沙勤导师梅长林朱有华教授学科专业内科学研究领域\研究方向学位级别博士学位授予单位第二军医大学学位授予日期2002 论文页码总数104页关键词角质细胞生长因子肾病囊肿衬里上皮细胞株肾囊肿馆藏号BSLW /2003 /R692 /1 ADPKD是人类为之付出昂贵代价的一种全身性遗传性疾病，是引起慢性肾功能衰竭的第四位病因，在临床上以肾脏满布大小不一并不断增大的囊性液泡、最终引起肾功能进行性损害为特征性的改变。

In the second part, we investigate the neurotrophy mechanism of qingkailing effective composition antagonizing ischemic injury, and comprehensively analyze the experimental results and come to the conclusions as follows: 1. Qingkailing effective composition can promote the activation of astrocyts during the early period after ischemia.

第二部分采用线栓法大鼠MCAO模型，围绕神经营养因子，从不同家族、同一家族的不同成员、同一成员的因子及其受体三个层次，探讨了清开灵有效组分抗局灶性脑缺血损伤的神经营养机制及效应特征。

Trial group incurred more outpatient costs and Nontrial group incurred more inpatient costs. Patients' median survival, receiving second line chemotherapy treatment, radiotherapy, surgery, patients with heart disease and those who received free drug while participating in clinical trials were all significant predictors of treatment costs.

分析影响病患医疗费用的因子，较长的存活时间、接受第二线以上化疗、接受放疗、接受手术、有心脏疾病等因子会显著增加费用，而参与由厂商提供免费新药的试验则会显著的使医疗费用减少。

In Smad pathway, by using cyclohexamide and proteosome inhibitor MG132, we showed that BMP-2 significantly increased inhibitory Smad ( i.e., Smad7) and down-regulated the half-life and protein levels of TbetaRI by poly-ubiquitination and proteosomal degradation.

在 Smad 讯息路径中，藉由转译抑制剂，cycloheximide 以及 proteosome 抑制剂，MG-132的刺激，我们发现第二型骨头成形蛋白可显著增加抑制型 Smad：Smad7的表现，使第一型乙型转形生长因子接受器走向 ubiquitin-proteosome 的水解路径，进而降低第一型乙型转形生长因子接受器的半衰期及蛋白质表现。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。