端细胞的

The Mayo Clinic team led by Lisa Boardman, M.D., a specialist in gastrointestinal malignancies, investigated the structures inside of cells known as telomeres, which are the caps on the ends of chromosomes that keep chromosomes from unraveling.

Mayo临床研究小组由恶性消化系统疾病专家Lisa Boardman博士领导，该小组对细胞内部的端粒酶进行研究，端粒酶是染色体两端的帽状结构，它可以保持染色体结构的完整性。

The malignant tumors included osteogenic osteosarcoma,metastasis tumor(six patients,two with pathologic fractures),chondrosarcoma,malignant fibrous histiocytoma (three patients,one with pathologic fracture),fibrosarcoma,and solitary myeloma.all patients received limb savage procedure with custom knee prosthesis including sevnteen cases of hinge joint and twentyone cases of posterior stability joints.

回顾分析我院接受定制型人工关节置换进行保肢治疗的股骨远端肿瘤患者38 例，其中良性肿瘤9 例，分别是骨巨细胞瘤7例(复发性骨巨细胞瘤5 例，骨折2例)，骨巨细胞瘤合并动脉瘤样骨囊肿1 例，骨母细胞瘤1 例；恶性肿瘤29 例，分别是成骨性骨肉瘤16 例，转移性肿瘤6例(骨折2例)，软骨肉瘤2 例，恶性纤维组织细胞瘤3例(骨折1例)，纤维肉瘤1 例，局灶性骨髓瘤1 例。

P-gp is expressed in normal biliary canaliculi of the liver, the adrenal cortex and proximal tubules of the kidney, and intestinal epithelia including the columnar cells of the large and small intestines; capillary endothelial cells of brain, testis, and placenta; and in the hematopoietic stem cells of bone marrow.

P-gp表达于正常的肝脏胆小管，肾脏的，肾上腺皮质和近端小管，以及包括大肠和小肠的柱状细胞在内的肠上皮细胞；脑、睾丸和胎盘的毛细血管内皮细胞；以及骨髓的造血干细胞。

Methods: We used a 5075 gene cDNA microarray to examine gene expression in peripheral blood mononuclear cells from two type 2 diabetes patients with distal symmetric polyneuropathy, two type 2 diabetes patients without distal symmetric polyneuro...

采用包含5075个功能已知人类基因的cDNA芯片检测2名2型糖尿病并发远端对称性多神经病变患者，2名2型糖尿病不伴远端对称性多神经病变患者以及2名年龄和性别匹配的正常个体外周血单个核细胞基因表达谱。

There are causal relationship between telomere loss and replicative senescence, and telomerase activation and cellular senescence.

文章综述了端粒和端粒酶的结构和功能，及其与细胞衰老的关系，并在此基础之上展望了其应用前景。

AIM: To study the mechanism of cisplatin interaction with DNA, and the attenuating effects of 6,7-dimethoxycoumarin on crosslink .

目的：研究顺铂与肾近端小管DNA的作用机制，和茵陈素的干预作用，方法：原代培养兔肾近端小管细胞。

It has been proved that wogonin effectively inhibits telomerase activity and tumor cell growth in vitro.

已有的研究表明，汉黄芩素体外具有抑制肿瘤细胞端粒酶活性和肿瘤细胞增殖的作用。

RESULTS: Stable telomerase activity could be detected in the transfected fibroblasts and no signs of cell senescence were found in the fibroblasts cultured for more than 50 doublings.

结果 转染 h TERT的人成纤维细胞能稳定表达端粒酶活性，培养超过 5 0代后细胞仍保持β-半乳糖苷酶阴性。

In order to elucidate the regulation mechanism of RU5 region to BFV gene expression, BFV3026 provirus DNA was used to construct the plasmids containing different deletion of R region, which were cotransfected with luc report gene locatied behind the IP promoter to BL12 cells, and luciferase activities was assayed, confirming that U5 region could repress the initiation function of LTR as well as IP. The BFV structure genes with different deletion of R region were cloned closely behind to heterogenous CMV promoter, then transfected to 293T cells, RT activity was performed, testifying the R region was required for BFV pol gene expression, and also the function domain was identified within the 100n.t. sequence at the 5′end.

以牛泡沫病毒(Bovine foamy virus， BFV)中国株BFV3026原病毒DNA为材料，构建R区系列缺失质粒，通过对其转染细胞中RT水平及对缺失质粒与luc报告质粒共转染细胞中萤火虫荧光素酶活性的测定，确立U5区对于BFV3026两类启动子LTR和IP均具有负调控作用；同时将带有不同R区的BFV3026结构基因片段克隆于异源启动子CMV之下，通过对其转染细胞293T中RT酶活性的测定，确立R区对于病毒结构基因pol的表达具有一定的调节作用，并将其功能区域初步界定在R区5′端100bp内。

The reticulated vessel which has large cavity has thicker wall due to more elastic fibers and more smooth muscles and its endothelium is cuboidal epithelium which has rotundity karyons. But the reticulated vessel which has small cavity has thinner wall due to less elastic fibers and less smooth muscles and its endothelial cells are flat epithelial cells which have long-shuttle-shaped karyons. In some regions, the ducts are very small in diameter and thin of wall, and they become blood sinus in the end.

管腔大者，管壁厚，弹性纤维、平滑肌纤维多，内膜靠腔面内皮细胞多成立方状，细胞核端位近圆形；管腔小者，管壁薄，弹性纤维、平滑肌纤维少，内皮细胞扁平、排列稀疏，胞核长梭形；一些区域管径极小，管壁极薄，成为开放的血窦，只允许一个血细胞通过。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。