端细胞

Telomerase is an attractive cancer target as it appears to be required in essentially all tumours for immortalization of a subset of cells, including cancer stem cells.

端粒酶是一个很有吸引力的癌症靶点，它在所有包括肿瘤干细胞在内的细胞亚型的永生化中起关键作用。

Results Cell immortalization was a multifaceted phenomenon,it was involved in viral DNA integration,activation of telomerase,inactivation of growth suppressors,and so on,and their roles were closely related.

结果细胞永生化涉及病毒DNA的整合，端粒酶的活化，生长抑制因子的失活等多方面的因素，它们的作用机制密切相关。

Telomerase activation was the samepathway of cellular immortalization and malignant transformation.

端粒酶的活化可能是细胞永生化或恶化的共同通路。

These results revealed that overexpression of c-Myc upregulated telomerase, which in turn resulted in immortalization of laryngeal squamous cells, and this mechanism existed not only in the initiation of laryngeal carcinogenesis but also in the whole process of cancer development.

这些研究表明，喉癌的发生可能是由于c-Myc的过度表达使端粒酶表达上调，从而使喉鳞状上皮细胞达到永生化，这一机制不仅存在于喉癌发生的早期，而且贯穿于喉癌的发展过程。

One feat researchers have achieved in the lab is using telomerase to 'immortalize' human cells.

实验取得的一项辉煌成就是用端粒使人类细胞"长生不老"。

PinX1 is a potent telomerase inhibitor in interphase; however, its function in mitosis is not well documented.

PinX1是一个潜在的间期端粒酶抑制因子，它在细胞有丝分裂期中的报道很少。

Telomerase may play a crucial role in the growth of leukemic cells. It may be a new target of treatment to leukemia.

端粒酶对维持白血病细胞的生长可能起十分重要的作用，它有可能成为白血病治疗的新靶点。

Objective To investigate the effect and mechanism of homoharringtonine on telomerase activity of human T lymphocyte Jurkat cells.

目的 探讨高三尖杉酯碱对人T淋巴细胞白血病细胞株Jurkat细胞端粒酶活性的影响及其机制。

The fact that telomere homolog oligonucleotides trigger SOS-like responses and cause selective apoptosis of malignantly transformed cells may provide an important clue to the prevention and treatment of photo-induced skin tumors.

端粒同源寡核苷酸引发SOS反应并导致恶性转化细胞发生选择性凋亡的特点为光源性皮肤肿瘤的防治提供一种新方法。

The morphological analysis of strain EMZY-1 showed that it was a straight rod, about 0.3×1.7 in size, and spherical and terminal spore appeared. Results of physiological and biochemical test showed that strain EMZY-1 was a Gram-positive bacteria, and could not grow when temperature was lower than 10℃ or higher than 60℃, pH was lower than 5.0 or higher than 12.0, and the concentration of NaCl was more than 10%. The strain EMZY could grow on the medium as a of sugar, glucose and mannite. The strain could use saccharose, glucose and mannitol as carbon resource, and NH4(superscript +) and NO3(superscript -) as nitrogen resource.

通过对该菌株的形态、培养特征、生理生化特征的研究以及16S rDNA序列分析表明：该菌株为革兰氏阳性菌；细胞为棒杆状，端生孢子，大小约0.3×1.7；温度低于10℃、高于60℃无明显生长；pH低于5.0、高于12.0无明显生长；NaCl质量浓度达到10%菌株不能生长；能在蔗糖、葡萄糖、甘露醇为C源的培养基上生长；NH4、NO3为菌株良好N源。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。