突触的

Radiolabeled pharmacological binding assay showed: 1 BmK AS bound specifically to a single class of non-interacting binding sites on both rat brain and cockroach nerve cord synaptosomes with high affinity and low low capacity. The association of BmK AS with both synaptosomes was quick to reach equilibrium, but the dissociation seemed to be only partial. The specific binding of BmK AS was independent of membrane potential, and couldn't be modified by veratridine. Moreover, the binding of BmK AS could be inhibited by native BmK AS, BmK AS1, BmK IT2 and BmK IT on both synaptosomes, but not or partially inhibited by BmK Ⅰ and suggesting BmK AS type neurotoxins might bind to a distinct receptor site on mammal and insect sodium channels with a similar manner from β-scorpion toxins.

二。蝎毒素多肽配体与哺乳动物和昆虫靶离子通道受体的药理结合特性及其靶结合位点的研究：经放射性标记结合和竞争抑制实验表明：1）BmK AS在大鼠脑和蟑螂神经索突触体上有单一非协同性高亲和力低结合容量结合位点，能快速结合并达到平衡，但仅能部分解离，其结合不依赖于膜电位，也不受藜芦碱调节，天然的BmK AS，BmK AS-1，BmK IT2和BmK IT可抑制〓AS与两种突触体的特异结合，而BmK Ⅰ无或仅有部分抑制效应。

PubMed abstract: To examine the relationship between synaptic plasticity and learning and memory as directly as possible, we have developed a new simplified preparation for studying the siphon-withdrawal reflex of Aplysia in which it is relatively easy to record synaptic connections between individual identified neurons during simple forms of learning.

PubMed摘要：为了尽量直接地研究突触可塑性与学习和记忆的联系，我们做了新的一个简化制备，目的是研究海兔缩虹吸反射，其中较容易在学习的简单形式中，记录个体确定之神经元的突触联系。

The in vitro effects of Gln49-PLA_2 were examined using the chick biventer cervicis nerve muscle preparation. Gln49-PLA_2 caused a dosedependent blockade of neuromuscular transmission. The time required to cause 50% blockade was about 150 min at the highest concentration 100μg/ml. This inhibition appeared to be presynaptic in origin as evidenced by the lack of effect of toxin on responses to exogenous acetylcholine in the non-stimulated BCp.

Gln49-PLA_2能够剂量依赖性地抑制颈二腹肌神经信号正常传导并影响肌肉收缩，在100μg/ml剂量下，肌肉收缩幅度在150分钟后达到50%的抑制率；同时，随着Gln49-PLA_2浓度的降低，肌肉收缩幅度的抑制效率也逐渐降低；实验证明Gln49-PLA_2对突触后膜乙酰胆碱受体敏感性无影响，对神经肌肉信号传导收缩的抑制作用位点在突触前膜。

With the advantage of being highly objective and efficient,the computer-aided analysis system for synaptic numerical density based on the Disector technique,Disector Countor 1.0,would be the developmental direction for synaptic numerical density analysis.

我们利用本文探讨应用Disector技术测量突触数密度的可行性和具体步骤，以及基于该技术的突触数密度计算机辅助分析的原理和过程。

The hippocampus is the most important encephalic region relative to function of learning and memory.

海马是学习和记忆的关键脑区，海马长时程增强(long-term potentiation，LTP)是NMDA受体依赖性突触传递效能的持续性增强，是脑学习和记忆功能在突触水平的研究模型和细胞基础。

NMDA(N-methyl-D-aspartate) receptors are a subtype of excitatory transmitters-glutamate receptor which belong to a heteromeric ligand-gated ionotropic receptors and play an important role in many complex physiological and pathological processes, such as nerve development, neuronal excitatory synaptic transmission, synaptic plasticity, central sensitization and neuronal death.

NMDA(N-methyl-D-aspartate)受体是兴奋性神经递质谷氨酸受体的一种亚型，是一种异聚体配体门控型离子通道，参与体内神经发育、神经元的兴奋性突触传递、突触可塑性、中枢敏化、神经元死亡等多种不同的生理和病理过程。

To estimate the contribution of thalamocortical and intracortical synapses to rapid adaptation, we applied electrical stimulation in VPM and barrel cortex and compared the electrical evoked responses of cortical neurons before and after adapting stimulation.

为了了解丘脑—皮层突触和皮层—皮层突触对皮层细胞快速适应的贡献，实验中分别在VPM和体感皮层施加电刺激，研究持续的感官刺激对电刺激诱导出的皮层细胞反应的影响。

Results ① Normal morphological structure of brain microvascular endothelial cells and neuroglial cells were injured by 1,2-dichloroethane, which damaged blood-brain barrier.

结果］染毒后的脑微血管内皮细胞呈进行性破坏，随着染毒剂量的加大细胞体积逐渐增大，胞膜模糊，细胞与细胞间、细胞与突触间连接减少，甚至消失；随着染毒时间的延长，在10、30、60min后可以观察到有进行性的细胞膜溶解破坏，胞核模糊，界限不清，突触变短。

alpha - the synapse nucleoalbumin is the soluble protein which one kind of central nervous system synapse, expresses, gets sick the morbidity with parkinson to have the close relationship.

α-突触核蛋白是一种中枢神经系统突触前表达的可溶性蛋白，与帕金森病的发病有密切的关系。

The immediate effects of this pharmacologic action are to increase the availability of norepinephrine and serotonin in the synapse and to increase stimulation of the postsynaptic neuron.

药理学活性的瞬即效应是为了提高突触对去甲肾上腺素和 5-羟色胺的利用率，也为了增值突触后神经元的兴奋。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。