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In addition, the number of synaptic sites that express detectable levels of GABARs was decreased by approximately 50% after activity blockade, although there was no reduction in the total number of presynaptic contacts.

另外,突触点的数量表示,在活动阻闭后GABARs可见的水准下降了约50%,虽然突触前接触的总数没有下降。

Puzzlingly, such effect is transient and depression is usually reinstated after the first episode of recovery sleep, or even after short naps .

睡眠剥夺可能通过改变5-羟色胺(serotonin 5-HT)系统起作用,5-HT_(1A)受体作为突触前的自身受体在调节中缝核5-HT神经元的活性中发挥着关键作用,并且作为突触后受体介导5-HT对边缘系统、皮层、下丘脑及其它一些脑区部位的作用,使得5-HT_(1A)受体的调节对于精神疾病非常重要。

Further study suggested that the D-serine produced in astrocytes regulates the function of NMDA receptor through the glycine-binding site of the receptor.

这种内源性D-Ser在神经系统中的分布与NMDA受体的分布相平行,进一步的研究表明,D-Ser由突触旁星形胶质细胞产生,而作用于突触后NMDA受体上的Gly结合位点,对NMDA受体的功能进行调控。

Importantly, the changes observed in rat muscle injected with mutant agrin recapitulated the pre- and post-synaptic modifications observed in the patient.

重要的是,大鼠肌肉注射突变型集聚蛋白后产生的变化和在患者中观察到的突出前和突触后变化一致。

The fEPSP response evoked in one pathway was small, usually 20–30% of the maximu, whereas a large response, usually 80–90% of the maximum, was evoked in the strong pathway. After recording of the baseline fEPSP evoked at 0.033 Hz, LTP of the weak pathway could be associatively induced by paired stimulation of the weak and strong pathways 100 times at 6 sec intervals, with stimulation of the weak pathway preceded 3–10 msec.

在记录以0.033Hz所引发基础的兴奋性突触后电位之后,在弱的路径上可以因配合弱与强的刺激路径而引发出相关性长期增益(每六秒一次共100次,弱的刺激路径在强的刺激路径之前 3-10 ms),然而当在两个路径之间的配合时间差大於10 ms时即无法形成相关性长期增益,此类型长期增益的引发是需要依赖活化NMDA接受器的,因为给予50 mM的D,L-AP5可以阻断相关性长期增益的引发(兴奋性突触后电位为原来的105±6﹪;n=6)。

Causing additional AMPA receptors to be assembled and inserted into the membrane of the postsynaptic cell.

使另外的AMPA受体重新分布并进入突触后膜,引起了突触连接的增强。

Using visual patch-clamp method synaptic transmission can be accurately assessed by measuring postsynaptic currents of the dorsal horn neurons.

用可视膜片钳方法可以准确测量脊髓背角神经元的突触后电流,从而研究初级传入突触的传递过程。

Whole-cell recordings were performed to record miniature excited postsynaptic currents after neurons were cultured for 1 week and 2 weeks.

培养到1周和2周时,采用膜片钳全细胞模式记录神经元突触内自发的微小兴奋性突触后电流。

The immediate effects of this pharmacologic action are to increase the availability of norepinephrine and serotonin in the synapse and to increase stimulation of the postsynaptic neuron.

药理学活性的瞬即效应是为了提高突触对去甲肾上腺素和 5-羟色胺的利用率,也为了增值突触后神经元的兴奋。

It required spiking of postsynaptic tectal cells as well as activation of NMDA receptors, and effectively occluded long-term potentiation of retinotectal synapses induced by direct electrical stimulation of retinal ganglion cells.

这需要突触后顶盖细胞的脉冲和NMDA受体活化,并有效闭塞连接视网膜和中脑顶盖神经纤维的突触长期的增强,这是由视网膜活动中心细胞的直接电激诱发的。

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