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The result indicates that the intracortical synaptic input was unchanged, but the thalamocortical synaptic input was depressed by sensory stimulation and this depression recovered with a time course that matched that of the recovery of sensory responsiveness.

结果表明,电刺激诱导出的皮层—皮层突触反应不受持续的触须刺激的影响,而电刺激诱导出的丘脑—皮层突触反应则由于持续的触须刺激而减小,而且突触反应的恢复时程与皮层细胞适应恢复的时程类似。

To clarify the effect of lidocaine oncholinergic synapse, we reconstructed a cultured soma–somachemical synapse model consisting of two identified visceraldorsal 4 (VD4) and left pedal e-1 (LPeD1) neurons from the snail, Lymnaea stagnalis , in vitro , and used it to determine how lidocaineaffects cholinergic synaptic transmission.

为了阐明利多卡因对胆碱能突触的影响,我们从椎实螺属 stagnalis 的蜗牛离体重建了含两种已被鉴定的内脏背4( VD4)和左足 e-1( LPeD1)神经元的培养体细胞-体细胞化学突触模型,来研究利多卡因如何影响胆碱能突触传递。

Increased concentrations to 2×10〓, 2×10〓mol·L〓, securinine potentiated both basal PS and the magnitude of LTP induced by HFS. 2、Effects of securinine on synaptic transmission in freely moving rats Rats were chronically implanted with a stimulating electrode in the perforant path of hippocampus and a recording electrode in the granule cell of dentate gyrus.

一叶萩碱对清醒自由活动大鼠海马齿状回突触传递活动的影响为了更直接的研究学习记忆与突触效能的关系,我们采取慢性种植电极,在大鼠清醒状态下,观察药物对近生理状态下大鼠突触传递的影响。

A major challenge in studying the synapse is how to tell what observed effects are due to presynaptic factors and which to postsynaptic ones.

研究突触最大的困难在于如何区辨所观察到的反应是来自突触前或突触后因子所导致。

The comparisons were made of amplitudes of the postsynaptic potential evoked in AP cells by stimulation of P and N cells.

采用同样的技术,分别对T、P和N细胞与邻节的AP细胞的突触连接方式进行了研究。T、P和N细胞与邻节的AP细胞的突触连接都是电突触

Ltp and ltd at excitatory neuronal synapses are observed to be induced by precise timing of pre- and postsynaptic events.

兴奋神经元突触的ltp和ltd是由突触前和突触后活动的精确定时所诱导。

Immunoelectron microscopic examination revealed that mGluR5 was prominently located in some neuronal somata and a lot of dendrites within the superficial layers of the spinal dorsal horn. Some dendrites containing mGluR5 constituted synaptic glomeruli with the terminals exhibiting the morphological characteristics of primary afferent C fiber. The ultrastructural features indicated that mGluR5 in the dorsal horn of the spinal cord may prominently work as a postsynaptical receptor to mediate or modulate the function of glutamate in the primary sensory transmission, including the nociceptive transmission.

免疫电镜研究显示,在脊髓背角浅层内,mGluR5主要定位在部分神经元胞体和大量树突内,并常见部分含mGluR5的树突与具有一级传入C纤维终末形态特征的轴突终末构成突触小球。mGluR5在脊髓背角浅层内的超微定位特征表明,脊髓背角内的mGluR5可能主要作为突触后受体介导或调节谷氨酸传递一级感觉的功能。

Results indicated that the GABAnergic system inhibition and pre-synaptic transmitter exhaustion may play an important role in short-term plasticity. And the short-term depression in thalamocortical visual pathway was strengthened when the cortex circuit get mature.

结果表明:GABA能系统的抑制作用和突触前递质衰竭很可能是决定该回路短时程抑制特性的主要因素;幼年大鼠与成年大鼠视觉系统短时程突触可塑性的对比研究表明,随着皮层回路的成熟,视觉丘脑至皮层通路的短时程突触抑制作用越来越强。

The present study was undertaken to explore the ultrastructural characteristics of synapses, especially the 5 HT ergic and retinal afferent synaptic connections in the hypothalamic suprachiasmatic nucleus of Tupaia belangeri chinensis, the unique native of South Chinas diurnal "primitive stock" which is more close to the Primates.

本研究借助免疫电镜和溃变纤维电镜追踪等技术,探索我国南方特产,昼行动物&灵长类原宗&树鼠句下丘脑视交叉上核的突触,特别是SCN中5-羟色胺(5-HT)能和视纤维传入的突触联系的超微结构特征,结果表明:TBC的SCN主要包含不对称性GrayⅠ型和对称性GrayⅡ型两种突触类型。

In fact, BDNF potentiates intracellular Ca~(2+) release presynaptically and BDNF-induced TrkB activation also results in phosphorylation of synapsin I via mitoen activated protein kinase, which increases the number of synaptic vesicles available for release.

事实上,BDNF能促进突触前细胞内Ca~(2+)的释放,TrkB的激活也能通过有丝分裂活化蛋白激酶,引起突触素I的磷酸化,进而增加可释放的突触囊泡的数量。

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