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These results demonstrate the important roles of Dvl and PAK in Agrin/MuSK induced AChR clustering, and reveal a novel function of Dvl in synapse development.

本文揭示了Dvl和PAK1在Agrin/MuSK引起乙酰胆碱受体聚集的信号传递途径中的作用,提示Dvl这个Wnt信号传递途径中的关键分子可能参与调节突触形成的过程。

Purpose With immunohistochemical methods under the light and eletronic microscopic level, together with the computer analytic techniques , the expression changes of the synaptophysin in the hippocampus of the rats that have obtained the abilities of spatial discriminative learning and memory established by water maze during the different periods will be studied, after they stopped training. Probing into the relationship between the amenia of the spatial discriminative learning and memory with the expression changes of the synaptophys in.

目的 用免疫组化的光、电镜方法结合图像分析技术,检测经水迷宫训练获得空间辨别性学习记忆功能后的大鼠在停止训练的不同时间段其海马结构内突触素表达的变化。

Amphibial Sympathetic ganglions are used broadly in the study of neurobiology including membrane and biophysics.

两栖类交感神经节广泛地用于神经生物学研究,包括突触和膜生物物理学研究。

PubMed abstract: A training procedure analogous to differential classical conditioning produces differential facilitation of excitatory postsynaptic potentials in the neuronal circuit for the siphon withdrawal reflex in Aplysia.

PubMed摘要:一个类似差异经典制约的训练过程在海兔的呼吸管撤回反射神经通路中产生差异的兴奋性突触后电位促进作用。

To explore how gene products, required for the initiation of synaptic growth, move from the cell body of the sensory neuron to its presynaptic terminals, and from the cell body of the motor neuron to its postsynaptic dendritic spines, we have investigated the anterograde transport machinery in both the sensory and motor neurons of the gill-withdrawal reflex of Aplysia.

为了探索突触形成起始阶段所需的基因表达产物,由感知神经细胞体向脊柱终端,以及由驱动神经细胞体向联会后枝状脊柱的移动,研究人员对与海蜗牛腮回退反射有关的,感知和驱动神经的顺式传递装置。

The contribution of facilitation of monostnaptic PSPs to dishabituation and sensitization of the Aplysia siphon withdrawal reflex . J Neurosci .

藉单突触PSP的运作以了解海兔回缩虹吸反射的移居性和敏感性〉,《神经科学学报》,1999 Dec 1;19(23):

Objective To find out the changes of synaptic density in the periaqueductalgray of the naive and kindled audiogenic seizures-prone rats.

目的 分析正常及点燃后听源性惊厥易感大鼠中脑导水管周围灰质内突触密度的变化情况。

The COD value in the dorsal and dorsolateral subdivisions of the PAG in the kindled audiogenic seizures-prone rats were significantly higher than that in the naive audiogenc seizures-prone rats.

用光镜观察PAG各节段各亚区切片上突触密度的变化,以期在光镜水平上了解PAG在惊厥状态下超微结构的某些变化。

Results The value of corrected optical density of the synaptophysin P38 immunoreactivity in the PAG of the naive and kindled audiogenic seizures-prone rats were significantly higher than that of the normal Wistar rats.

据此,本实验以P38免疫细胞化学反应的强度为指标,间接地对听源性惊厥易感大鼠(P77PMC)中脑导水管周围灰质(periaqueductal gray, PAG)各亚区突触的分布情况进行了研究。

The effective stimulating sites were indentified by defensive cardiovascular response and other components of defence reaction evoked by 3 s trains of rectangular cathodal pulses (100Hz, 0.5ms pulse duration, 70 -150μA intensity for dPAG and 150-250μA for PF) delivered from a programmed multichannel constant current stimulator. The responses included an increase in blood pressure and heart rate, pupillodilation and an increase in the rate and depth of respiration. Currents of 1Hz, intensity of 100- 150μA for dPAG and 200-250μA for PF were used to observe the effect of the stimulation of them on RVLM neurones. The deep peroneal nerve and superfacial deep peroneal nerve were carefully separated, and put on a pair of stimulating electrode respectively, Both nerves were stimulated with constant rectangular pulses of 1Hz, 0.5ms duration and 300μA current intensity to see their effects on RVLM neurones. The baro-and chemo-receptors were activated by the intravenous injection of phenylephrine or 0.208 M NaH2PO4. The degree of convergent inputs to individual RVLM neurone was studied by the stimulation of the sites mentioned above. It was found that neurones about 61.4%(27/44) and 35.3%(6/17) received convergent inputs from three and four places respectively.

过去的研究主要集中于整体水平,利用电刺激或化学刺激RVLM神经元,观察对血压、心率及交感活动的影响,并对影响心血管交感活动的神经递质进行了广泛探讨,积累了大量资料;在神经元水平,主要研究刺激脑内核团、外周神经、化学感受器及压力感受器等对RVLM神经元放电的影响和某些神经递质影响神经元活动的机制、然而,对RVLM神经元如何整合不同信息、其可能突触机制等研究得较少,本互作拟采用在体细胞内、细胞外记录电活动与微电泳,结合中枢核团及外周神经电刺激等方法,对RVLM神经元在不同状态下的整合作用规律与可能机制进行初步探讨,为进一步了解这一复杂的整合过程提供新的理论依据。

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