突眼的

METHODS: Adult male Wistar rats, 9 weeks of age, were injected intraperitoneally with STZ to create diabetes. At 2 week after the models were created, BDNF protein was administered into the vitreous cavities of rats. At 4 week after the models were created, the rats were killed and the retina was removed for Western blotting and Whole-mount immunohistochemistry for TH to observe the changes of TH and dopaminergic amacrine cells in retina.

9周龄Wistar大鼠，链脲佐菌素（streptozotocin，STZ）腹腔注射，制成糖尿病模型，于模型建立2wk后，大鼠眼玻璃体内注射BDNF溶液，于模型建立4wk后，处死大鼠，取出眼球，取视网膜组织进行Western blotting及视网膜铺片免疫组织化学染色检测，观察视网膜中TH水平的变化，从而反映糖尿病大鼠视网膜中多巴胺能无长突细胞水平的变化。

Review articles only; calretinin; fovea centralis; macula lutea; ora serrata; photoreceptors; rods; cones; optic tract; optic nerve; visual cortex; color vision; photoreception; opsin; rhodopsin; guanine nucleotide-binding protein; G protein-coupled receptors; ion channels (cyclic GMP-gated); guanylate cyclase; cyclic GMP; dark adaptation; visual pigments; polyenes; 11-cis-retinal; vitamin A; chromophores; arrestin; recoverin; phosducin; transducin; bipolar cells; retinal ganglion cells; retinal progenitor cells; amacrine cells; Mueller cells; light; retinogenesis; ommatidia; optic vesicles; retinitis pigmentosa; blindness; macular degeneration; blind spot; Mach bands; electroretinograms; binocular vision; visual acuity; vision; retina

唯一综述；钙网膜蛋白；中央凹；黄斑；锯齿缘；光感受器；杆状细胞；圆锥细胞；视束；视神经；直观皮层；色视觉；光感受；视蛋白；视紫质；鸟苷酸-结合蛋白；G蛋白-电偶受体；离子通道；鸟苷酸环化酶；环鸟苷酸；暗适应；视色素；多烯；11 - cis -视网膜；抗干眼醇；发色团；抑制蛋白；恢复蛋白；phosducin；转导蛋白；双极细胞；视网膜神经节细胞；视网膜祖细胞；无长突细胞；米勒细胞；光；retinogenesis；小眼；视泡；色素性视网膜炎；盲的黄斑变性；盲点；马赫带；视网膜电流图；双目视觉

Calretinin; fovea centralis; macula lutea; ora serrata; photoreceptors; rods; cones; optic tract; optic nerve; visual cortex; color vision; photoreception; opsin; rhodopsin; guanine nucleotide-binding protein; G protein-coupled receptors; ion channels (cyclic GMP-gated); guanylate cyclase; cyclic GMP; dark adaptation; visual pigments; polyenes; 11-cis-retinal; vitamin A; chromophores; arrestin; recoverin; phosducin; transducin; bipolar cells; retinal ganglion cells; retinal progenitor cells; amacrine cells; Mueller cells; light; retinogenesis; ommatidia; optic vesicles; retinitis pigmentosa; blindness; macular degeneration; blind spot; Mach bands; electroretinograms; binocular vision; visual acuity; vision; retina

光感受；视蛋白；视紫质；鸟苷酸-结合蛋白；G蛋白-电偶受体；离子通道；鸟苷酸环化酶；环鸟苷酸；暗适应；视色素；多烯；11 - cis -视网膜的；抗干眼醇；发色团；抑制蛋白；恢复蛋白；phosducin；转导蛋白；双极细胞；视网膜神经节细胞；视网膜祖细胞；无长突细胞；米勒细胞；光；retinogenesis；小眼；视泡；色素性视网膜炎；盲的；黄斑变性；盲点；马赫带；视网膜电流图；双目视觉；视敏度；视觉；视网膜

Gene mutations were detected in 25 patients and a 18-year-old girl among 16 families. Trinucleotide repeats of CAG were 73～79. The fragments of abnormal alleles were 380～402bp, and all patients were heterozygous. The copy numbers of normal alleles were 18～40, fragments from 202～270bp. SCV reduction was much obvious compared to MCV, MCV and SCV in lower limb ?ere much more slow than that in upper's. BAEP, VEP were also delayed in latency. The anticipation in parental sex bias were much more obvioius than that in matental's. Cerebellar ataxia was most severe, the next were dysarthria and bulging eyes. Amytrophy was seen only in bed ridden patients. Cerebellar atrophy was more severe than brain stem, cord atrophy was n't observed in all MJD.

结果检出10个家系25例病人及1例症状前18岁女孩有MJD基因突变，CAG三核苷酸重复73～79次，异常等位基因片段长380～402bp，均为杂合子；正常人CAG三核苷酸重复18～40次，等位片段长200～270bp，电生理发现MJD的SCV减慢比MCV明显，而下肢的MCV、SCV又较上肢明显，BAEP、VEP均有不同程度的潜伏期延长或波的异常；MJD的父亲遗传早于母亲，进展也较块，临床以小脑性共济失调为突出症状，其次为构音障碍、突眼等，肌肉萎缩仅见于晚期病人；MRI示小脑萎缩较明显，脑干萎缩并不严重，未见明显的颈髓萎缩。

Ve: To observe the curative effect of Yantu Fang for relapse of Graves' disease after hormone treatment.

目的：观察自拟眼突方治疗Graves眼病激素治疗后复发的疗效。

Graves' ophthalmopathy is a common autoimmune disorder that display with Graves' disease showing characteristic clinical feature such as proptosis,eyelid retraction and chemosis.

葛瑞夫兹氏眼病变为伴随葛瑞夫兹氏症常见的自体免疫疾病，其主要临床症状包括眼突、眼睑外翻及结膜水肿。

4The diameter and length of the clinoid segment of internal carotid artery are 4.02±0.58mm(2.80—5.11mm)and 3.06±0.89(1.07—5.04mm).

5绝大部分眼动脉发自颈内动脉床突上段，占93.75﹪，它的直径为1.52±0.27mm(0.94—1.97mm)。

We introduced improved primary mixed glial culture and different-attachment method to isolate and purify the OPCs, the cells were proliferated in serum-free medium, flow cytometry and immunohischemistry methods were employed to estimate the purity of cultured OPCs. Their abilities of differentiation and expression of trophic factors were identified by RT-PCR and immunostaining. Several methods including TUNEL and MTT were adopted to estimate the protective effects of conditioned culture medium from oligodendrocyte lineage cells on the primary cultured cerebellar granule neurons. Intravitreal transplant of OPCs, combined with retrograde fluorescent labeling the superior colliculus and intraorbital optic nerve transection, were used to investigate the protective effects of OPCs on the axotomized RGCs in vivo. Intravitreal transplantof OPCs or NSCs on the newborn rats, and retinal transplant of OPCs on the young rats were performed, to observe the myelin formation in the retina at different stages after cellular transplantation. Optic nerve transection was carried out on some rats with myelinated retinae, to study the influence of myelination on the injuried RGCs.

为此，本研究采用改良的胶质细胞混合培养与差速贴壁方法获得大鼠OPCs，使用无血清培养基进行扩增、培养，用免疫组织化学和流式细胞技术对培养细胞的纯度进行鉴定，对少突胶质系细胞表达部分营养因子的情况进行检测；采用TUNEL、MTT等方法对少突胶质系细胞条件培养基对原代培养小脑颗粒神经元的保护作用进行检测；将OPCs移植入成年SD大鼠玻璃体内，利用上丘逆行荧光标记技术，观察眼内移植的OPCs对眶内视神经切断时的视网膜神经节细胞的保护作用及其持续时间；将OPCs或NSCs移植入新生和幼年SD大鼠玻璃体或视网膜内，观察不同时期视网膜内髓鞘形成与分布特点，分析髓鞘的超微结构，并观察眼内髓鞘形成对损伤神经节细胞的保护作用。

Data were analyzed from photographs from optical microscopy and Computer Image Analysis.Results:Gene expression level of bcl-2mRNA (numeric density and concentration of bcl-2 immunopositive neurons) in layer Ⅲ of the ipsilateral visual cortex area 17 and the laminas receiving ipsilateral geniculate input from the strabismic and deprived eyes are significantly lower than the input from the untreated eyes.

MS1和MD1组幼猫实验眼同侧视皮质17区Ⅳ层及同侧外侧膝状体Al层神经元在视觉发育敏感期内，由于长期的斜视及形觉剥夺效应以致功能低下，对Bcl-2调节的敏感性降低，以及对NTs的营养保护及上调Bcl-2 mRNA表达水平应答能力降低，在双眼竞争的神经元发育及突触连接中处于劣势，使对侧眼形成优势循环。

Baimai Spring, Winter Sweet Spring, Ink Spring, East Mawan Spring, West Mawan Spring and Eye-Clear Spring are all among the 72 Most Famous Springs of Jinan.

百脉泉、梅花泉、墨泉、东麻湾、西麻湾、眼明泉为济南七十二名泉，涌珠浮翠、透泄天真的百脉泉自古有&西则趵突为魁，东则百脉为冠&赞誉。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。