突眼

A 29-year-old male with a 5-year-history of hyperthyroidism complained of diplopia and proptosis.

摘要一位29岁男性，有5年甲状腺机能亢进病史，主诉有复视和突眼等症状。

Analysis of the medical history in association with the positive physical and laboratory findings suggested a clinical diagnosis of exophthalmia thyrotoxicosis.

综合病史，体格检查及化验检查结果分析，临床诊断考虑为突眼性甲状腺毒症。

Results The etiology of exophthalmos in children includes two aspects:（1）the outside of ocular diseases,mainly including Langerhans cell histiocytosis,chloroma,neuroblastoma etc.（2）ocu-lar diseases,mainly including retioblastoma,rhabdomyosarcoma of the orbit,glioma of optic nerve and angioma of the orbit and so on.

结果 提示小儿突眼病因主要包括两方面：（1）眼外疾患，主要包括有郎格罕组织细胞增生症、绿色瘤、神经母细胞瘤等；（2）眼部疾患，主要包括视网膜母细胞瘤、眶横纹肌肉瘤、视神经胶质瘤、眶内血管瘤等。

Of the 20 haptics in 10 patients, 9 were adequately located in the sulcus region, the others were located in chamber angle, ciliary processes or posterior to the ciliary processes.

在继发性青光眼10只眼20只人工晶状体襻中，9只襻准确固定在睫状沟内，其他位置包括前房角、睫状突及睫状突后。

We introduced improved primary mixed glial culture and different-attachment method to isolate and purify the OPCs, the cells were proliferated in serum-free medium, flow cytometry and immunohischemistry methods were employed to estimate the purity of cultured OPCs. Their abilities of differentiation and expression of trophic factors were identified by RT-PCR and immunostaining. Several methods including TUNEL and MTT were adopted to estimate the protective effects of conditioned culture medium from oligodendrocyte lineage cells on the primary cultured cerebellar granule neurons. Intravitreal transplant of OPCs, combined with retrograde fluorescent labeling the superior colliculus and intraorbital optic nerve transection, were used to investigate the protective effects of OPCs on the axotomized RGCs in vivo. Intravitreal transplantof OPCs or NSCs on the newborn rats, and retinal transplant of OPCs on the young rats were performed, to observe the myelin formation in the retina at different stages after cellular transplantation. Optic nerve transection was carried out on some rats with myelinated retinae, to study the influence of myelination on the injuried RGCs.

为此，本研究采用改良的胶质细胞混合培养与差速贴壁方法获得大鼠OPCs，使用无血清培养基进行扩增、培养，用免疫组织化学和流式细胞技术对培养细胞的纯度进行鉴定，对少突胶质系细胞表达部分营养因子的情况进行检测；采用TUNEL、MTT等方法对少突胶质系细胞条件培养基对原代培养小脑颗粒神经元的保护作用进行检测；将OPCs移植入成年SD大鼠玻璃体内，利用上丘逆行荧光标记技术，观察眼内移植的OPCs对眶内视神经切断时的视网膜神经节细胞的保护作用及其持续时间；将OPCs或NSCs移植入新生和幼年SD大鼠玻璃体或视网膜内，观察不同时期视网膜内髓鞘形成与分布特点，分析髓鞘的超微结构，并观察眼内髓鞘形成对损伤神经节细胞的保护作用。

The efficacy of group C treated with steroids on proptosis was 63.6%, group D with additional retrobulbar injection and E with additional intrathyroid injection were 78.6% and 80% respectively. Conclusion The efficacy of steroids on proptosis is valid. Additional retrobulbar injection or intrathyroid injection can improve its efficacy.

糖皮质激素对突眼的疗效是肯定的，可能是通过调节细胞因子的水平而发挥作用，球后或甲状腺注射能提高疗效。

The incidence of exophthalmos,arrhythmia,periodic paralysis and medicamentous liver lesion was higher in men than in womenP.001,P.01,P

男性甲亢在突眼征、心律失常、周期性麻痹、药物性肝损害等的发生率高于女性(P.001，P.01，P.05)。

Data were analyzed from photographs from optical microscopy and Computer Image Analysis.Results:Gene expression level of bcl-2mRNA (numeric density and concentration of bcl-2 immunopositive neurons) in layer Ⅲ of the ipsilateral visual cortex area 17 and the laminas receiving ipsilateral geniculate input from the strabismic and deprived eyes are significantly lower than the input from the untreated eyes.

MS1和MD1组幼猫实验眼同侧视皮质17区Ⅳ层及同侧外侧膝状体Al层神经元在视觉发育敏感期内，由于长期的斜视及形觉剥夺效应以致功能低下，对Bcl-2调节的敏感性降低，以及对NTs的营养保护及上调Bcl-2 mRNA表达水平应答能力降低，在双眼竞争的神经元发育及突触连接中处于劣势，使对侧眼形成优势循环。

Methods: 61 cases of patients with thyrotoxic exophthalmos in our hospital were given case analysis and comprehensive evaluation after the treatment of Tripterygium Wilfordii united Tapazole Prednisone.

我院61例甲亢突眼住院患者，经雷公藤多苷联合他巴唑强的松治疗后，分析病例并综合评价其疗效。

Thyrotoxic exophthalmos; Tripterygium Wilfordii united Tapazole Prednisone; Clinical efficacy; Case analysis

甲亢突眼；雷公藤多苷联合他巴唑强的松；临床疗效；病例分析

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。