突变的

Methods Multinuclear cell assay was used to investigate the frequency of hprt locus mutation both in normal healthy people and malignant tumor patients prior to and after radiotherapy with a cumulative dose of 54~72Gy.

采用多核细胞法研究肿瘤患者及其接受放疗后外周血淋巴细胞HPRT基因位点的突变频率，并与正常人群进行对比。

Methods By using immunohistochemical fechnique, MDT-PCR-SSCP and direct sequencing the mP53 expression and point muta- tion in exon 6 of p53 gene in both Solt-Farber model and DEN-induced liver cancer model were detected.

通过DEN诱发的启动模型和肝癌模型，应用免疫组化、MDT－PCR－SSCP和直接测序技术分别研究mP53表达和 p53基因第6外显子点突变。

But , mutagenic action is not the only mechanism of hereditary change , the epigenetic mechanism may also play an important role in it.

然而，致突变作用并不是遗传改变的唯一机制，表观遗传基础对此也具有重要作用。

The results of our study show that (1)ionizing radiation was mutagenic to E.

3γ射线剂量率对三株菌的致死和致突变影响大剂量率强于小剂量率。

Data from animal studies indicate EMS is teratogenic, mutagenic and carcinogenic; however, no data from humans exist.

从动物实验数据显示：EMS是致畸胎、致突变及致癌物质；对人类的影响目前尚无资料。

No manufacturing of carcinogenic or mutagenic substances.

无致癌或致突变物质的制造。

Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

研究者认为，IDH1具有肿瘤抑制子的作用，一旦IDH1发生突变失活则导致HIF-1通路发生改变促进肿瘤发生。

Objective To explore the effect of the mutant and expression level of N-ras on chronic myelogenous leukemia.

目的 探讨N-ras基因突变及表达水平与慢性粒细胞白血病发病的关系。

Objective To explore the role of C/EBPα gene mutations in the pathogenesisof acute myeloid leukemia.

目的：探讨髓系转录因子 C/EBPα基因突变与急性髓系白血病发生的关系。

Objective: To investigate the prevalence of penicillinase-producing Neisseria gonorrhoeae in Wuxi.

目的 探讨淋球菌青霉素结合蛋白2基因突变及产青霉素酶淋球菌与耐青霉素类药物的关系。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。