突变的

That the aging of advanced societies has been a sudden change.

先进社会的老龄化都是一种突变。

A missense mutation (2879 A→G) in ADAR gene is detected in the DSH family, which is probably one of the molecular bases of the pathogenesis of the disease.

DSH家系中患者ADAR基因存在错义突变(2879 A→G)，这可能是导致DSH发病的分子机制之一。

The analyses show that the break of the aerodynamic force causes the disturbance.

分析认为，空气动力在控制过渡过程中发生突变导致了这种扰动的产生。

Some factors were found to affect the expression of aguA in E.

得到一系列突变基因并将它们成功的插入到表达载体pTrc99A和pHsh中得到重组质粒。

Seeds of Ailanthus altissima Swingle were treated with 60Co γ-rays at the doses of 0, 30, 50, 75, 100, 150 and 200Gy, the effects of irradiation on seed germination and seedling growth were studied. The results showed that irradiation inhibited germination, and decreased the survival rate and the growth of plants.

以椿树种子为材料，用60Coγ射线进行了0、30、50、75、100、150和200Gy辐照处理，研究辐照对椿树种子发芽及幼苗生长的影响，以期获得耐盐突变体。

This review describes the research progress of its bioactive constituents and molecular biology in allium tuberosum .

韭菜是人们十分喜爱的佳蔬，它不仅营养丰富，而且具有多方面的保健功能，如抗菌、抗突变、抗氧化和温肾助阳等。

AIM: To explore the effects of APC and p53 gene mutations in colorectal carcinoma.

目的：探讨APC和p53基因突变在结直肠癌中的意义。

The experimental results indicated that only the AphA(26-320) has the function of autoassemblying with PCB.

结果表明，只有缺失突变体AphA(26-320)能与PCB进行自发的体外重组。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

This parameter canaccurately describe the degree of concentration of vibratory energy of the systemmodal shape in quantity. Using this parameter, the effects of mistuning on thelocalization of system modal shapes for various orders are studied. The reasons of themodal localization phenomenon are analyzed by the perturbation method.

利用所提出的模态局部化参数，研究了失谐对叶盘系统各阶模态局部化程度的影响规律，并利用摄动法对失谐所导致的模态局部化现象进行了分析；同时还发现，失谐叶盘系统的某些中间阶模态的局部化参数值在弱耦合区域的特定位置会产生奇异的突变现象，而这种突变现象是用摄动法难以解释的，并且可能会对失谐叶盘系统的振动稳定性产生重要影响。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。