突变的

Root hairs of wild type were intensely induced in the presence of NAA, while the gls mutant was insensitive to NAA induced root hair initiation; Lateral roots of the wild type were dramatically decreased when treated with 2,4-D, while the gls mutant was insensitive to 2,4-D induced reduction in lateral root initiation; The seminal root length of wild type showed no obvious changes by the treatment with IAA, but the gls mutant was supersensitive to IAA with dramatic reduction in seminal root length, suggesting that the interactions of GLS gene with different hormones may involve different mechanisms.

外源NAA 处理强烈诱导野生型根毛发生，而gls突变体则不敏感；外源2，4-D处理，野生型侧根急剧减少，gls突变体则不敏感；外源IAA处理，野生型种子根长变化不明显，而gls突变体超敏，种子根长迅速变短，表明GLS基因与不同激素有不同的互作机制。

The typical clinical manifestations of SPD are soft tissue syndactyly between the third and fourth fingers,and between the fourth and fifth toes,with a supernumerary digit in the syndactylous web.p.Q317R point mutation located in the homeodomain of HOXD13 can result in typeⅤsyndactyly(MIM 186300),which is characterized by fusion of the fourth and fifth metacarpal.

本研究对HOXD13同源盒p.Q317R点突变和多聚丙氨酸延展突变进行功能研究，探索这两种突变导致不同并指畸形的分子机制。

This example is carried through equation transformation, whose last expression is compared with potential function of cusp catastrophe model.

概述了突变理论的几种简单突变模型，通过举例进行方程转化并利用尖点突变模型，对系统进行了脆性分析

To study genetic mutations of methylenetetrahydrofolate reductase C677T and cystathioinine-β-synthase T833C related to homocysteine metabolism in patients with ischemic stroke, the MTHFR gene C677T gene mutation and the CBS T833C gene mutation were detected by PCR-RFLP or ARMS method in 74 patients with ischemic stroke and 83 normal people for control. Results showed that the frequencies of MTHFR genet homogenetic type(2.7%), heterogenetic type(51.4%) and T allele(28.4%) in ischemic group were higher than those in control group(1.2%, 39.8% and 21.1%, respectively).

为研究同型半胱氨酸代谢相关酶亚甲基四氢叶酸还原酶基因C677T和胱硫醚-β合成酶基因T833C位点碱基突变与缺血性脑卒中的关系，对74例缺血性脑卒中患者和83例健康对照者，采用聚合酶链反应-限制性片段长度多态性技术检测MTHFR基因C677T基因型，用扩增阻滞突变体系法检测CBS基因T833C突变。

Results Mobiligy shifts of SSCP in exon 5 of presenilin-1 was detected in 4 cases with Alzheimer,s disease. Two missense mutation were found in the patients by DNA sequence analyse, one mutation was Leu 130 Met and the other was Vall 57 Leu.Another 11 patients showed one single strend shifted rapidly. But none mobility shifts of SSCP were found in patients with vascular dementia and normal controls. Conclusions It is shown that mutations in exon 5 of presenilin-1 also exist in the patients with sporadic Alzhemer?

结果 发现4名SAD患者的PCR产物SSCP分析发生泳动异常，DNA序列分析发现：这4名SAD患者的130号密码子发生了CTG→ATG错义突变(388位点发生C→A突变)，使编码的氨基酸由亮氨酸变为蛋氨酸(Leu 130 Met)；157号密码子发生了GTG→CTG错义突变(469位点发生G→C突变)，使编码的氨基酸由缬氨酸变为亮氨酸(Val 157 Leu)，另有11名患者SSCP表现为一条单链增快，其性质待定。

Results showed 172 DH plants in 2006, 230 DH plants in 2007 were obtained, 275 plants had been domesticated in 2008.Some DH regeneration plants could transform into leaf mutants. From 2006 to 2007, 8 wrinkledness leaf mutants were gotten. The highest rate of getting mutants was 2.29 %. 2 mutant plants had gotten seeds. The leaf mutants mainly showed wrinkledness in the surface of preceding leaves at early stage. Then the wrinkle leaves could transfer to normal ones and some also keep the wrinkledness later with their growth.

结果表明，CGMCC№2553具有胚胎发生能力，2006年获得172株DH再生植株，2007年获得230株，2008年驯化275株；定植到日光温室中的DH再生植株有些会转变为叶片突变体，2006~2007年共获得8株叶片皱缩突变体，最高获得率为2.29%；目前已获得2份突变体的自交种子；叶片突变体主要表现：生长初期叶片表面皱缩呈瘤状，随着生长的进行，一些皱缩的叶片转变为正常，有的则依然皱缩。

EMB-resistance in 18 isolates was caused by the mutation at coden 306 in embB gene with positive rate of 62.1%. The PCR result was negative in 20 specimen from pulmonary diseases without active TB and 5 negative control strains of no MTB. The data in this study showed high specificity of 100%. Only one specimen in 7 specimen with negative result in acid-fast stain and cultivation was shown alteration in coden 306 in embB gene.

结果：130例活动性肺结核患者痰标本抗酸染色阳性38例，阳性率为29.2%(38/130)；罗氏培养阳性为79例，阳性率为60.8%(79/130)。79例培养阳性痰标本中耐乙胺丁醇29例，其中有18例在embB基因met306ATG突变，基因突变率为62.1%。20例非结核肺部疾病患者痰标本和5株非结核分枝杆菌菌株经套式PCR扩增全部为阴性，特异性为100%。7例涂阴培阴PCR扩增阳性的序列中有1例在embB基因306位密码了发生突变。

Together with the cited sequences of other species (cattle, zebu cattle and buffalo), the molecular phylogenetic tree was therefore built to probe phylogenetic relationship between Bovine subfamilies, Total 5 variation sites were examined and two types of mutation, transition and transversion, were observed, with the overage percentage of nucleotide variation of 1.66%. It demonstrated the poverty of polymorphism at exon 5 of GH gene of three bovine species. There was only one missense mutation out of 5 mutation sites which led to the shift between leu and val amino.

结果表明，在雷琼牛、巴州牦牛和巴州蒙古牛中共检测到5个变异位点，核苷酸取代方式仅有转换和颠换，核苷酸平均突变率仅为1.66%，说明这3个牛种GH基因外显子5多态性较为贫乏；5个变异位点中仅有1个为错义突变，导致亮氨酸和缬氨酸的转换，但该突变在牛种中分布有差异。

The mutant displays defects in both compound leaf architecture and leaflets polarity pattern. Backcross test indicates the nl1 phenotype is caused by mutation on a single recessive locus.

研究显示nll突变表型是由单位点隐性突变造成的，突变体中小叶原基提前起始、小叶极性模式改变、叶脉模式改变，同时影响花器官发育和茎维管束模式建成。

The mutant displays defects in both compound leaf architecture andleaflets polarity pattern. Backcross test indicates the nl1 phenotype is caused by mutation ona single recessive locus.

研究显示nl1突变表型是由单位点隐性突变造成的，突变体中小叶原基提前起始、小叶极性模式改变、叶脉模式改变，同时影响花器官发育和茎维管束模式建成。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。