突变的

AIM: To establish a transgenic mouse model of Hi1tchirtson-Gilford progeria syndrome and observe the effect of mutant lamin A on the implantation and survival ability of injected mouse zygotes.

目的：制备Hutchinson-Gilford早老症转基因小鼠模型，观察突变的核纤层蛋白A对小鼠受精卵着床和成活情况的影响。

Before she realised it, many of her investments had been savaged by the sudden collapse of equity prices and the switchback of the yen.

在她意识到这一点之前，她的许多投资已遭受股市突然崩盘和日元走势突变的沉重打击。

The studies on NTA-2 agriculture characters showed that it closes glume, videlicet it doesn" t blossom. Compared with Aijiaonante which is a natural mutant from NTH, NTA-2" s culm length increase and kilo grain weight lighten. The increased culm length of NTA-2 is mainly due to the elongation of every internodes.

对南特矮-2的性状分析表明：同南特号自然突变的矮脚南特相比，南特矮-2是全闭颖授粉：株高略高，各节间均有所增长；叶片较窄长，分蘖较少，茎秆较粗；穗长减小，结实率下降，千粒重较小。

The statistical analysis of this large set of mutations has led us to propose a diagnostic strategy that should help with the molecular work-up of optic neuropathies.

这一大系列基因突变的统计学分析引导我们提出一个诊断策略，可以帮助我们对视神经病变进行分子学的诊断检查。

The introduction of cabbage BoCAL gene into cauliflower may bring great influence to the expression of the mutated bobcal gene and cause the alteration of curd phenotype.

将甘蓝BoCAL基因转入花椰菜，有可能对突变的bobcal基因的表达有重要影响。

The DNA sequences around the transposon inserted site were also amplified by inverse PCR and sequenced. Multisequence alignments showed that the mutated genes were highly similar to the malonyl coenzyme A transacylaseg gene, lipopeptide synthetase B gene and sensor histidine kinase gene, respectively.

反向PCR克隆转座插入位点周边序列及测序结果表明，转座突变的基因与编码脂肽类化合物合成和调控相关的malonyl coenzyme A transacylase、lipopeptide synthetase B和sensor histidine kinase蛋白基因具有高度同源性。

OBJECTIVE: To investigate the relationship between the clinical manifestations of a patient with MELAS and a novel mitochondrial DNA mutation.

目的：探讨1例MELAS患者的临床表现和线粒体基因突变的关系。

Methods PCR- SSCP and DNA sequencing were used to analyze the PTCH gene mutations in 12 OKCs, including 10 sporadic and 2 nevoid basal cell carcinoma syndrome associated OKC.

方法采用PCR—SSCP筛查与DNA直接测序的方法对12例OKC进行PTCH基因突变的检测，其中2例为痣样基底细胞癌综合征相关OKC，10例为散发OKC。

Mutations in the promotor region of ALOX5 and LTC4S genes reduce response to leukotriene modifiers.

在ALOX5与LTC4S基因突变的病人对白三烯素调节剂的反应下降。

MtDNA mutation result in insulin deficiency by tricarboxylic acid cycle obstruction.

此外，细胞线粒体的异质性决定其突变的致病效应不同。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。