突变型

Furthermore, a genetic screen was carried out to identify modifiers of the phenotypes associated with the constitutive expression of a dominant negative kuz transgene in developing imaginal discs.

另外，根据能否改变突变型kuz基因在器官芽中过量表达引起的表型，我们对覆盖了果蝇25％必须基因的2383个P因子插入突变进行了遗传筛选。

The confocal laser scanning microscopy revealed that the cyto-skeleton of MEL and MEL-M organized incompactly while the F-Actin organization of MEL-W was compact.

由激光共聚焦显微镜观察到，MEL和转突变型p53的MEL细胞骨架排列松散，而转野生型p53的MEL细胞骨架交联多且致密。

With confocal laser scanning microscopy, it was found that the mutant type p53 protein was located in the cytoplasm while the wild type p53 protein was located in the karyon.

用激光共聚焦显微镜观察到突变型p53蛋白定位于胞浆，而野生型p53蛋白则定位于胞核内。

Second, we tested the ability of IL-15 and its mutants to induce LAK cell from PBMC.

其次，测定了野生型和突变型诱导外周血白细胞LAK细胞活性的功能。

The result suggested that expression of tumor suppressor gene p53 was concerned with occurrence and development of avian leukosis subgroup J.

这一结果提示突变型抑癌基因p53的表达参与蛋鸡J亚群禽白血病发生、发展过程。

The melanic mutant strain of Spodoptera exigua, SEM, was derived from yellow wild strain, SEW. The pupae of SEM were black.

甜菜夜蛾Spodoptera exigua黑色突变型是由黄色正常型发生突变而来，SEW的蛹为黄色，而SEM的蛹为黑色。

We thus hypothesized that increased TGF-beta signaling may contribute to the multisystem pathogenesis of MFS, including the development of myxomatous changes of the atrioventricular valves.

研究者使用抗游离和激活型TGF-β的单克隆抗体观察到，突变型小鼠二尖瓣叶内的免疫激活性增加，&表明TGF-β的激活而不是细胞因子的生成增多&。

It was reported that OP-1 was responsible for the induction of nephrogenic mesenchyme during the development of embryonic kidney. Absence of OP1 would lead to kidney dysplasia. With OP-1 gene knock-out, nude mice died of renal failure within the first 24 hours after birth.

研究发现，OP-1在胚胎肾脏发育期间与肾原性间充质的诱导有关，其缺乏导致肾脏发育不良，OP-1基因敲除突变型的裸鼠在出生后24小时内死于肾功能衰竭。

Moreover, in comparison of birth lengths in eight subgroups defin ed by organic solvent status (nonexposure/exposure) and maternal genotype for MS P1 and GSTM1, in the presence of organic solvents ' exposure , the birt h length was a clear gradient of adverse effects .

3我们将芳香烃溶剂，母亲基因MSP1（野生型、杂合子/突变型）与基因GSTM1分为8组，在芳香烃溶剂暴露组，可见母亲基因型致出生身长呈斜线降低，然而在芳香烃溶剂非暴露组，其母亲基因型对出生身长的影响无明显改变。

The current antifungal agents used in clinics usually have severe side-effects, it is necessary to seek for new antifungal agents with known or new mechanisms. China has abundant resources in traditional Chinese medicine, therefore exploition of new antifungal agents therefrom is a feasible way.We have screened antifungal activities of 14 ethanolic extracts from traditional Chinese medicines and 21 natural products by using Saccharomyces cerevisiae GL7 and Prototheca wickerhamii as the model microoranganisms. Among the TCMs tested, Cortex Phellodendri, Flos Caryophylli, Fructus Mume, Rhizoma Coptidis and Radix Sophorae tonkinensis showed high antifungal activity. This study layed certain foundation for the development of new antifungal agents.

为了开发中药资源，从传统中药中寻找有抗真菌活性的天然药物并阐明其作用机理以利于临床应用，论文对14种生药乙醇提取物及21种生药化学成分利用啤酒酵母突变型GL7（Saccharomyces cerevisiae GL7）和威克海姆原藻作为模式菌种进行了抗真菌活性筛选，其中黄柏、丁香、乌梅、黄连和山豆根等有很好的抑菌活性，为进一步研究开发成新的抗真菌药奠定了基础。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。