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The effects of vacuolization on the differentiation of vascular endothelial cells were analyzed from a chemical biochemistry genetics perspective using the blastodisc cells differentiation model induced by FGF with the γ-butyrolactones derivative.

从化学遗传学的角度,利用γ-丁内酯衍生物研究了成纤维细胞生长因子(fibroblast growth factor, FGF)诱导鸡胚盘细胞向血管内皮细胞分化过程中,空泡化对血管内皮细胞分化的影响。

The experimental results show the validness of the mechanism analyses.2. According to the generation mechanism of the leak acoustic signal, the characteristics of the leak acoustic signal are investigated. The auto correlation technology is adopted to descript the leak signal characteristics due to the ability to analyze the coherence of time series. A new procedure to identify the leak acoustic signal from the disturbed noises is proposed based on the conjunction of correlation and approximate entropy algorithm.3. The principle and application in leak location of the correlation and the adaptive filter techniques are introduced. The problems of the traditional leak location methods are analyzed.4. In order to establish the leak detection signal model, the leak acoustic propagation characteristics are investigated experimentally.

从泄漏声产生机理出发,分析了管道泄漏处湍流拟序结构与空泡间相互作用的机理,认为在该机理作用下,泄漏声信号产生过程具有&不可重复&的特征;由于相关函数具有分析时间序列拟序结构的能力,且近似熵从统计的角度区别时间过程的复杂性,因此,提出将信号相关分析和近似熵理论相结合的方法,提取泄漏声信号&不可重复&的特征,辨识管道泄漏故障发生;在实际检测现场,由于各种管内和管外固定声源噪声(如阀门噪声、工地施工噪声等)常导致泄漏误判和漏点定位错误,重点分析了管内固定噪声源的产生机理和特征,为复杂干扰环境下的泄漏辨识提供理论支持。

Results: There were 14 cases of solitary bronchioloalveolar carcinoma, the distance of pleura to the centre of pulmonary node was smaller than 3.1cm, node diameter from 1.4cm to 3.5cm, the CT morphologic features of nodes were margin slick 2 cases, irregular margin 6 cases, short barb 5 cases, pleural retraction 11 cases, bronchogram 6 cases, vacuole 12 cases. 5 cases of consolidation bronchioloalveolar carcinoma, the main features were multisegment or lobes inflammatory consolidation, bronchogram phase 4 cases, and honeycomb 3 cases. 6 cases of diffused bronchioloalveolar carcinoma, the main features were widespread diffusion nodes, inequality of size, anisodistribute.

结果:孤立结节型14例,结节中心距胸膜均小于3.1cm,病灶直径为1.4~3.5cm,CT表现有边缘光滑2例,呈分叶征6例,短毛刺征5例,胸膜凹陷征11例,含气支气管征6例,空泡征12例;炎症型或实变型5例,病变呈多个肺段或肺叶的炎症样实变,见支气管气相4例,以及蜂房状含气腔3例;弥漫结节型6例,弥漫分布粟粒状与结节状致密影,大小不等,分布不均。

It is one of the efficient approaches that the air-film is accreted on blade surface of operative marine propeller for improving cavitation characteristics.

在船用螺旋桨桨叶表面充气以形成气膜是改善其空泡特性的有效方法之一。

When a superspeed underwater vehicle runs in cruise phase,its motion mode is different from that of a usual bedewed vehicle because a majority of its surface is surrounded by supercavitation.

超高速水下航行器运行于巡航阶段时,由于大部分表面被超空泡所包覆,其运动模式完全不同于常规的全沾湿水下航行器,表现出独有的运动特性。

Results: CPCC treatment was found to effectively attenuate the degenerative changes observed in alloxan-induced animals, such as hypertrophy of liver, adhesion phenomenon between adjacent hepatic lobules, crimpling and partial necrosis of hepatocytes, inflammatory cell infiltration, vacuolation, endothelial cell injury and the nuclear damage etc.

结果:CPCC处理使四氧嘧啶处理后小鼠肝脏肿大、肝小叶粘连现象明显改善;肝指数降低;减轻肝细胞变形、肝窦淤血、炎症细胞浸润及肝细胞空泡样变、血管内皮细胞损伤,核变性程度同时CPCC能有效防止四氧嘧啶所致小鼠肝脏可溶性蛋白的变化。

According to the observed of TEM,mitochondrial of the epithelial cells were vacuolized, the cristae and membrane had disappeared. Rough endoplasmic reticulums were expansion.

透射电镜观察上皮细胞线粒体空泡化、嵴和膜消失,粗面内质网扩张,杯状细胞内含有大量的粘原颗粒。

Results showed that there were the morphological changes of mitochondria, such as vacuolization, degeneration and cristae swelling or disappearance, in HT-29 cells treated by C2-ceramide for 24 hours. Under the fluorescence microscope, mitochondria of apoptotic cells aggregated and emitted red fluorescence, however, mitochondria of normal cells emitted green fluorescence. The mitochondrial membrane potential began to decrease after 6 hours in HT-29 cells treated with C2-ceramide in time and dose dependent manner.

结果显示C2-神经酰胺作用HT-29细胞24小时,线粒体发生空泡化、变性、嵴肿胀或消失等形态学改变;此时荧光显微镜下可观察到线粒体聚集,发出红色荧光,而正常细胞线粒体发出绿色荧光。C2-神经酰胺作用细胞6小时,线粒体膜电位即开始降低,呈时间-剂量-效应关系。

Pathohistologic examination revealed normal glomeruli but vacuolar degeneration of tubular epithelial cells, and part of them disrupted and desquamated, and also tubular dilatation. Only mild pathological changes were seen in the intervention groups.

肾脏病理检查可见LPS组肾小球大致正常,而肾小管上皮细胞空泡变性,部分上皮细胞崩解、脱落,管腔扩张,两个UT干预组肾小管病理变化均较LPS组减轻,不同剂量组间形态差异无显著性。

Under the transmission election microscope, we had observed that the state of oocytes arid the cumulus cells around them was tightness, and there were plenty of long and thin microvilli playing the role of connection in the enwrapping. The shape of cumulus cells nucleus was ovate, and the longer and shorter diameters of the cumulus cells were 4.250±0.042μm and 2.750±0.07 μm respectively. The zona pellucida was well proportioned and tightly linking with oocyte. There were great deals of multi-crista mitochondria, lipid droplet and vacuolus. The mitochondria longer and shorter diameters were 0.600±0.106μm and 0.490±0.117μm. Granular nucleoplasma distributed very well in the cell nucleus.

电镜下,卵母细胞外的卵丘细胞紧紧包裹卵母细胞,且与卵母细胞之间有大量细长的微绒毛相联系;卵丘细胞核呈卵圆形,其长径为4250±0.042μm,短径为2.750±0.071μm;透明带均匀,与卵母细胞结合紧密;在皮质区集中分布大量的多峰型线粗体、脂滴和空泡,线拉体长径为0.600±0.106μm,短径为0.490±0.117μm;细胞核中颗粒状的核质分布非常均匀。

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