穹

Objective To observe the expression of nicotinic acetylcholine receptor in the brain's fimbria/fornix transected rats, the effect of ectogenic estrogen on it, and its relation with Alzhelmer's disease.

目的 以双侧穹隆海马伞切断制作阿尔茨海默病大鼠模型，观察脑内海马CA1区和皮层区烟碱型乙酰胆碱受体表达的变化，探讨与 AD相关的发病机制，并观察雌激素的干预作用。

RT-PCR/Southern blot was used to detect the change of Brn-4 mRNA expression in hippocampus after fimbria fornix transection.

取各组大鼠的海马组织，提取总RNA，采用RT-PCR/Southern 杂交方法分析穹窿海马伞切割后海马内Brn-4 mRNA的表达变化。

the increase of lhx8 mrna expression after fimbria fornix transected might be related to the regeneration mechanism of differentiation of neural stem cells into cholinergic neurons in hippocampus.

切割穹窿海马伞后海马中lhx8 mrna表达的增高可能与神经干细胞向胆碱能神经元分化的再生机制有关。

The bilateral fimbria-fornix of brain was transected in the fimbria/fornix transaction group.

在脑立体定位仪上，切断大鼠脑的双侧穹隆海马伞同时切除双侧卵巢，建立模拟AD的动物模型。

One group served as normal control and the others served as the 1st, 3rd, 7th, 14th, 21st and 28th day group after fimbria fornix transection, respectively.

42只SD大鼠随机分成正常对照组和切割穹窿海马伞后1、3、7、14、21及28 d组。

Fimbria/fornix transaction cutting can cause the increased of Aβ1-40 expression in many sections of the brain, which might be related to the cognitive disturbance due to Alzheimer disease.

穹隆-海马伞切断和去势的大鼠脑内多部位Aβ1-40表达增多，此可能与老年性痴呆病理改变有关。

Then hippocampi were isolated and total RNA was extracted. RT-PCR/Southern blot was used to detect the change of Brn-4 mRNA expression in hippocampus after fimbria fornix transection.

取各组大鼠的海马组织，提取总RNA，采用RT-PCR/Southern杂交方法分析穹窿海马伞切割后海马内Brn-4 mRNA的表达变化。

Objective To observe the expressive varieties of β-amyloid（A β1-40）peptide in different sections of the rat brain with fimbria/fornix transaction and to study the pathogenic mechanisms related to Alzheimer disease.

目的 采用穹隆-海马伞切断及去势的大鼠模型模拟阿尔茨海默病病人，观察模型大鼠脑内不同部位β淀粉肽1-40(Aβ1-40)表达的变化，了解A β1-40与阿尔茨海默病相关的发病机制。

The expression of TrkA positive neurons is decreased in many sections of the brain in the rats with fimbria/fornix transection.Possibly it is the cause leading to the cognitive disorder and senile dementia.

穹窿海马伞切断大鼠脑内多部位酪氨酸激酶A表达减少，这种病理变化可能是认知障碍和老年性痴呆的原因之一。

Objective: To investigate the difference of Brn-4 mRNA expression between the fimbria fornix transected rats and normal ones.

作者：董传明秦建兵，金国华，王磊，朱蕙霞，田美玲目的：探讨切割穹窿海马伞大鼠海马与正常海马内Brn-4 mRNA表达的差异

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新