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稀释药

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Methods:The minimum inhibitory concentration of the olive polyphenol against the common oral pathogenic bacterium was quantitatively determined with the agar-agar dilution method combined with the micro liquid dilution method.

选用质量控制标准菌株和临床分离的对多数抗生素耐药的菌株,采用琼脂稀释法和微量液体稀释法相结合的药敏实验方法,定量测定橄榄多酚对口腔颌面部感染常见病原菌的最低抑制浓度。

Results show that detonation velocity of compound explosive declines from 3100 m·s-1 to 2100 m·s-1 when mass ratio of attenuant rises from 20% to 60%(explosive loading thickness is 30 mm ),and the density of compound explosive rises from 0.615 g·cm-3 to 0.76 g·cm-3 when mass ratio of attenuant rises from 20% to 50%.

结果显示,当稀释剂含量从20%增加到60%时,混合炸药的爆速(药厚:30 mm)由3100 m·s-1降到2100 m·s-1,炸药的密度也由0.615 g·cm-3增加到0.76 g·cm-3(稀释剂含量: 20%~50%);稀释剂含量为50%的混合炸药,当药厚在25~50 mm范围内时,爆速保持在2300~2360 m·s-1之间。

Methods①The minimum inhibitory concentration and the minimum fungicidal concentration of citral against C.

方法①参照NCCLS M27A方案中的微量液基稀释法测定柠檬醛和氟康唑对原始白念珠菌的最低抑菌浓度和最低杀菌浓度;②采用多步诱导法,观察在含梯度浓度(1~50MIC)柠檬醛培养基上连续转种的白念珠菌MIC的变化情况,以氟康唑作为阳性对照,同时设空白对照和溶媒对照;③将敏感性下降的诱导株在无药培养基上连续转种10次后,检测其MIC值;④测定柠檬醛对氟康唑敏感性下降诱导株的MIC值。

Objective To study the effects of acute normovolemic hemodilution on the pharmacokinetics of high-dose fentanyl undergoing open heart surgery.

目的 研究心内直视手术中急性血液稀释自体输血对大剂量芬太尼药代动力学的影响。

Ethyl acetate extract of sappanwood is dilued with olive oil.use the equivalent dosage of active compound sappanwood 35g, 45g, 55g/kg to intragastric administration;blank control group use 0.2ml/10g olive oil to intragastric administration.

苏木乙酸乙酯提取物用橄榄油稀释,以相当于原药苏木35g、45g、55g/kg的剂量灌胃;空白对照组灌服同体积的橄榄油。连续灌胃8天后处死。

The minimum inhibitory concentration of the eight fishery antibacterial drugs are determined and its inhibitory action and bactericidal effects on the Aeromonas hydrophila used respectively and combinedly are compared by using double dilution method and inhibition zone method.

采用二倍稀释法及抑菌圈法测定了目前常用的8种抗菌渔药对嗜水气单胞菌的最低抑菌浓度,比较了这8种抗菌渔药单独用药与联合用药对嗜水气单胞菌的抗菌效果。

Drug sensitive test and three-dimensional test220 strains of Pa were isolated from hospitalized patients between 2003 and 2007. K-B method was used to tested the susceptibility of 10 different antibiotics. IRPa was screened by testing the minimal inhibitory concentration of imipemem by using agar diluiion method.The susceptibility of these IRPa to the antibiotics was analysised. Three-dimensional test was used to identify the different kinds of beta lactamases from 220 strains of Pa.2.Carbarpenems hydrolytic enzyme genes and oprD2 gene were detectedamong the selected IRPa strains, PCR method was performed to detect carbapenemase genes which included GES、KPC、SPM、VIM、IMP、GIM gene and the oprD2 gene;Multiplex PCR were used to detect OXA genes and plasmid-mediated AmpC beta lactamase genes; The expression of the chromosomal AmpC beta lactamases and oprD2 genes in IRPa strains were analyzed by Real-time PCR.3.Identification and characterization of integronsIntegrase gene was detected by PCR, and the classification of integrons was performed by using restriction fragment length polymorphism.PCR was performed to detect the qacE△1-sull gene,and the gene cassetes which are located at variable region of integrons in the strains were detected to be positive.

方法1、药敏实验和三维实验收集2003~2007年临床分离的220株Pa,对这些菌株采用K-B法测定10种临床常用抗生素的药敏情况,同时采用琼脂稀释法检测亚胺培南的最低抑菌浓度(Minimal inhibitory concentration,MIC),筛选出对亚胺培南耐药的铜绿假单胞菌,并分析其对其它抗生素的药物敏感率;采用三维实验的方法分析220株Pa产β内酰胺酶的类型。2、碳青霉烯类水解酶和oprD2蛋白的检测针对鉴定的IRPa菌株,采用普通PCR方法检测具有碳青霉烯水解作用的β内酰胺酶耐药基因(GES、KPC、SPM、VIM、IMP、GIM基因)和oprD2基因,采用多重PCR的方法检测OXA型基因和质粒携带的AmpC酶基因,用荧光定量RT-PCR方法检测oprD2蛋白基因表达情况;同时对产AmpC酶的Pa(25株,含IMP耐药和敏感株)用RT-PCR方法检测AmpC酶基因的表达量情况。3。

ATB Hemophilus influenza susceptibility test and broth dilution method could be used in Hemophilia influenza susceptibility test.

ATB嗜血杆菌药敏试验和肉汤稀释法均可用于临床分离的嗜血杆菌药敏试验。

The race to develop new blood thinners is going intooverdrive.

开发新的血液稀释药竞争将会变得更加白热化。

Methods: A randomized, single blind controlled clinical design was used to accomplish the series clinical trials included 123 cases. The troop of gatifloxation injection with sodium chloride included 20 cases in gatifloxation group and 23 cases in ciprofloxation group; The troop of gatifloxation injection with glucose included 21 cases in gatifloxation group and 19 cases in levofloxacin group; The troop of gatifloxation pivoxil included 19 cases in gatifloxation group and 21 cases in ciprofloxation group. The antibacterial activity of clinical isolates were detected by scrips which contain gatifloxation(5ug/L), levofloxacin (5ug/L), ciprofloxation (5ug/L), spafloxation(5ug/L), cefotaxime(30ug/L), penicillin(10U/L) respectively. The MICs of sixkinds of antibiotics were detected by 2-fold agar dilution method. Result: The common data of patients in the two groups of 3 troops were similiar.

采用区组分层均衡随机单盲试验设计,分别完成甲磺酸加替沙星氯化钠注射液组试验药20例及对照药23例、甲磺酸加替沙星葡萄糖注射液组试验药21例及对照药19例、甲磺酸加替沙星片剂组试验药19例及对照药21例共123例感染患者的临床试验;用K-B法测定临床分离致病菌对加替沙星(5ug/L)、左氧氟沙星(5ug/L)、环丙沙星(5ug/L)、司帕沙星(5ug/L)、头孢噻肟(30ug/L)、青霉素(10U/L)纸片的敏感性,再用按美国国家实验室标准委员会(National Committee for Clinical Laboratory Standards,NCCLS)推荐的琼脂平皿对倍稀释法测定临床分离菌株对加替沙星、左氧氟沙星、环丙沙星、司帕沙星、头孢噻肟、青霉素的最低抑菌浓度(Minimum Inhibitory Concentration,MIC)以了解其体外抗菌活性。

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