种

We also showed that coadministration of AG825 or AG1478 will enhance the efficacy of cytotoxic AGent cisplatin.

了解5种人类非小细胞肺癌细胞系A549、H322、H358、H460、H1299的HER2和EGFR蛋白表达水平，探讨5种细胞系HER2蛋白表达水平与顺铂IC50之间的关系；观察HER2和EGFR小分子酪氨酸激酶抑制剂AG825和AG1478对5种细胞系的生长抑制作用；观察AG825、AG1478联合顺铂对5种细胞系的协同生长抑制作用；研究AG825、AG1478联合顺铂对H322、H1299细胞系细胞增殖、细胞周期、细胞凋亡和坏死的影响；研究AG825、AG1478联合顺铂所致H322、H1299细胞系EGFR、磷酸化ERK和总ERK表达的变化，探讨协同生长抑制作用的机制。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

This study was conducted at 10 subtidal and 4 intertidal sampling sites in Dongsha Atoll by SCUBA diving and snorkeling during May 13-20 and August 20-22, 2004. A total of 133 mollusk species were collected, within which Muricidae being the most abundant family with 16 species, followed by family Conidae with 14 species. Twenty five species were first recorded in Dongsha Atoll. Species with economical value, e.g.

於2004年5月13日至20日和8月20日至22日期间在东沙岛海域十个亚潮带测站和四个潮间带测站进行底棲软体动物调查，经利用潜水观察记录和採集標本方式，目前已整理出133种软体动物，以骨螺科16种最多，其次为芋螺科14种，其中更有25种为东沙岛首次记录到之种类。

This study was conducted at 10 subtidal and 4 intertidal sampling sites in Dongsha Atoll by SCUBA diving and snorkeling during May 13-20 and August 20-22, 2004. A total of 133 mollusk species were collected, within which Muricidae being the most abundant family with 16 species, followed by family Conidae with 14 species. Twenty five species were first recorded in Dongsha Atoll. Species with economical value, e.g.

於2004年5月13日至20日和8月20日至22日期间在东沙岛海域十个亚潮带测站和四个潮间带测站进行底栖软体动物调查，经利用潜水观察记录和采集标本方式，目前已整理出133种软体动物，以骨螺科16种最多，其次为芋螺科14种，其中更有25种为东沙岛首次记录到之种类。

There were seven glandular organ artery of superior thyroid artery distribution patterns with the L1R1 predominant (37.25%), five non-glandular organ artery of superior thyroid artery distribution patterns, and three kind branches (laryngeal artery, cricothyroid artery and sternocleidomastoid artery), and two distribution patterns of inferior thyroid glandular organ artery.

本研究共统计分支类型：甲状腺上动脉腺体支7种，左右各1支(L1R1)最多见(37.25%)，非腺体支5种分支类型，3种分支，即喉上动脉、环甲动脉及胸锁乳突肌动脉，甲状腺下动脉腺体支2种分支类型。

The total seed storage in topsoil (0-10 cm) was 83499-109141 indm^(-2) for natural wetlands and 9140-47452 indm^(-2) for reclaimed paddy fields. In natural wetlands, the seeds were of 16-30 grass plant species, being dominant with Polygonaceae and Cyperaceae or Cyperaceae and Gramineae; while in reclaimed paddy fields, the seeds were of 7-16 grass plant species, with the dominant of Gramineae. The seed storage and species numbers were greater in Shengjin Lake than in Shibasuo Lake. Higher seed bank storage and more species were observed in the paddy fields from Shibasuo wetland with 30 years of cultivation than from the Shengjin Lake wetland with over 50 years of cultivation.

结果表明：天然湿地种子库密度为83499~109141粒m^(-2)，而开垦为稻田30~50年后种子库密度为9140~47452粒m^(-2)；天然湿地的土壤种子库物种数为16~30种，以蓼科－莎草科或莎草科－蓼科为优势种，开垦为稻田后物种数下降为7~16种，且趋向于以禾本科为单一优势种；此外，与十八索湿地相比，升金湖湿地有较高的土壤种子库物种数、丰富度和多样性，而开垦年限为30年的十八索稻田土壤种子库物种数和丰富度显著高于开垦年限为50年的升金湖稻田。

These two qualities, the daunting and the fascinating, combine in a strange harmony of contrasts, and the resultant dual character of the numinous consciousness, to which the entire religious development bears witness, at any rate from the level of the 'daemonic dread' onwards, is at once the strangest and most noteworthy phenomenon in the whole history of religion.

帕斯卡认为世界上有两种智慧：一是那种简单无知的大众，他们生活在传统与想象的智慧中，以似乎是盲目，毫无抵抗的方式彻底掘弃自己地相信一种信念，然后通过约定俗成的礼仪与传古的神话来巩固自己的信念；另一种是圣人与哲人，这是一种通过科学，理性与哲学的探讨来认识自己的无知。

The decision making method of uncertain multi-attribute is applied to select bamboo species for constructing a project on 500 thousand mu(equivalent to 33350 hectare) pulpwood base of bamboo pulping paper in Jinghong.In detail,combined G with Zi based on OWA,it concludes that Z4=Lingnania distegia,Z2=Dendrocalamus hamiltonii,Gx1=Dendrocalamus giganteus,Gx2=Dendrocalamus peculiaris are finally selected as bamboo species for base target management;Z16=Dendrocalamus barbatus as prepared bamboo...

应用不确定多属性决策方法为拟建的《景洪竹浆纸项目50万亩竹子原料林基地》项目的热带大型丛生竹选择竹种，将多准则模糊决策方法的满意度G值和基于OWA算子的多属性决策方法的综合属性值Zi结合起来考察，最终选定：Z4=料慈竹，Z2=版纳甜龙竹，Gx1=龙竹，Gx2=金平龙竹4个竹种作为基地的目的经营竹种；Z16=小叶龙竹作为将来发展的储备竹种。

In woody taxa, 175 of 1,005 (17.4%) taxa are dioecious while only 65 of 2,047 (3.2%) herbaceous taxa are dioecious in Taiwan.

在台湾本岛1，005种木本被子植物中，有175种为雌雄异株植物(17.4%)，而在2，047种草本植物中，则仅有65种(3.2%)为雌雄异株。

From this point of view, the writings about the history of aesthetics might be put into two disrelated categories: one is the'intangible or metaphysical'history of aesthetic ideas, such as Chinese Aesthetic History and the Outline of Chinese Aesthetic History in many different versions and another is the'tangible or physical'history of aesthetic artifacts, such as Chinese porcelain, Chinese calligraphy and brush drawings and Chinese bronze utensils in various versions.

以此观之，国内迄今为止的美学史著作，似呈&道&、&器&分流的两种形态：一种是&形而上&的审美思想史，如诸种版本的《中国美学史》、《中国美学史大纲》等；另一种是&形而下&的审美物态史，像诸多版本的《中国陶瓷》、《中国书画》、《中国青铜器》等。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。