离子间的

This dissertation divides into seven chapters and the main contents and conclusions are listed as following:1. Three series binuclear lanthanide carboxylate coordination polymers 1～7 have been synthesized under hydrothermal conditions by altering the length of carbon chains between carboxyl group and phenyl ring on ligands, which are isophthalic acid, 1,3-phenylenediacetic acid and 1,3-phenoxydiacetic acid, and lanthanide ions such as Pr~(3+), Eu~(3+)and Ho~(3+).

论文共分七章，主要研究内容和结论如下：1、通过改变间苯二甲酸配体的羧基和苯环之间的碳链长度，从间苯二甲酸、间苯二乙酸到间苯二氧乙酸，以及改变稀土离子半径Pr~(3+、Eu~(3+)和Ho~(3+)出发，在水热条件下制备了三个系列双核金属单元的稀土羧酸二维配位聚合物1～7。

Nine kinds of compounds are synthesized with NTO〓, PA〓, TNR〓'used as acid radical, and CHZ, SCZ·HCl, AG·H〓CP〓 served as the materials. Among them eight kinds of compounds have been never reported in the literature and one has been prepared at home for the first time. The structures of these compounds are characterized by using the element analysis and the FT-IR measurements.

以3-硝基-1，2，4-三唑-5-酮离子、2，4，6-三硝基苯酚离子、2，4，6-三硝基间苯二酚离子为酸根，以碳酰肼、盐酸氨基脲、氨基胍重碳酸盐为原料合成富氮化合物，得到了8种未见文献报道的新富氮化合物，另有1种是国内首次合成的新型富氮化合物。

Results:Biochemical indicators: the concentrations of K+, Na+ and Cl－ in the serum after the infusion are different with those before the infusion; other indicators don't have the significant difference. The mean infusion time of group A is longer than that of group B (p=0.006), while the dosis letalis of KCl doesn't have significant difference between groups (p=0.062); the concentrations of K+ in blood, Na+, Mg2+ and Cl－ in serum have the significant difference between groups; the urine volume and the concentrations of all the urine electrolyte indicators don't have the statistical significant difference between groups.

结果：生化指标：输入钾前后，家兔血清钾离子浓度升高，钠、钙及氯离子浓度降低，具有统计学显著性差异，p=0.000；全血钾及血清其他离子浓度变化，以p=0.05为标准，不具有统计学显著性差异。A、B两组间比较结果：A组输液致死时间长于B组(p=0.006)，致死输钾量无统计学显著性差异(p=0.062)；全血钾、血清钠、镁及氯离子浓度变化值具有显著差异，血清钾、钙、碳酸氢根离子浓度变化值无明显的差异；尿量和尿液各电解质浓度指标无统计学显著性差异。

In this thesis, a series of complexes based on aromatic multicarboxylic acids have been successfully synthesized in solutions or under hydrothermal conditions. Their structure and properties are investigated.(1) Eight complex compounds have been synthesized and characterized by X-ray single crystal diffractive technology: The eight complexes are listed as following: [Cu242] complex 1 [Cd22(H2O)4]·4H2O complex 2 [Co(H2btc)(H2O)3] complex 3 [Co2(H2O)2]·H2O complex 4 [Ni22(H2O)4] complex 5 [Cu22(H2O)4] complex 6 [Co(H2biim)2(H2O)2](H2btc) complex 7 [Zn(H2biim)2(H2O)2](H2btc) complex 8 The structure of complex 1 is dinuclear complex resulted from weak interactions（0-D chain）; complex 2 is 1-D chain stucture result from interactions of water molecules; complex 3、4、5、6 are coordination polymers using hydrothermal synthses, where the first kind ligand is H4btc, the second kind ligand is phen and Co2+、Ni2+、Cu2+ as center ions, respectively. While the coordination enviroment of Co2+ is the same in complex 3, the coordination geometries around the Co atoms in complex 4 are obviously different because of the different reaction conditions. In complex 4, the 1-D chains are connected into 2-D layer through carboxy groups of ligand H4btc. The structures of complex 5、6 are 1-D chain stucture result from interactions of carboxy groups in ligand H4btc. Complex 7、8 are homeomorphy compounds. Either of them are linked to the 3-D chains through intermolecular hydrogen bonds. Each H4btc lose two protons and H2btc2- acts as negative electron balance.

合成了8个结构新颖的配合物，并用X-射线单晶结构分析方法确定了晶体结构，分别为： [Cu242] 配合物1 [Cd22(H2O)4]·4H2O 配合物2 [Co(H2btc)(H2O)3] 配合物3 [Co2(H2O)2]·H2O 配合物4 [Ni22(H2O)4] 配合物5 [Cu22(H2O)4] 配合物6 [Co(H2biim)2(H2O)2](H2btc)配合物7 [Zn(H2biim)2(H2O)2](H2btc)配合物8 配合物1是一个依靠弱作用连接的双核铜结构；配合物2借助水分子形成一维链状结构；配合物3、4、5、6是以H4btc为第一配体、phen为第二配体，通过水热法合成的配合物，其中，Co2+、Ni2+、Cu2+为中心离子；配合物3中的二价钴离子具有相同的配位环境，不同反应条件下得到的配合物4中的二价钴离子存在不同的配位环境，在配合物4中，一维链通过H4btc上的羧基形成一个二维层结构；配合物5、6是借助H4btc上的羧基形成的一维链状结构；配合物7、8属于异质同晶结构，它们的分子通过分子间氢键形成三维网状结构，H4btc上的羧基失去2个质子，作为一个二价负离子起到电荷平衡作用。

On the basis of intrapair and interpair correlation model, we have calculated the pair correlation energies of different kinds of systems, analyzed the changing rules of correlation energies of various electron pairs, and developed a reasonable and simple scheme called "Separating Large System into Smaller Ones". The basic idea of this scheme is that the correlation energy contributions of actual components in the ionic compound can be obtained using the correlation energy of ions with integer charge as the boundary conditions and incorporating the HF wave function or the distribution of electron cloud, then the total correlation energy of the system can be estimated by linearly summarizing the correlation contributions of these components.

在对内对间电子相关能理论模型的基础上，进行各类型化学键分子体系电子相关能的计算，分析电子对相关能的变化规律，建立合理的、&化整为零&的电子相关能简捷计算方案，其基本思想是对于离子键体系以整价离子的电子相关能为边界条件，通过HF波函数或电子云分布求得大体系中实际离子的电子相关能后，进行线性加和，即&化整为零、聚零为整&的思想。

Two coordination polymers composed of in situ synthesized ligand deriving from isophthalic acid through the hydroxylation on the 2-position have been synthesized under hydrothermal conditions.

利用铜离子的氧化还原性质，以铜离子和间苯二甲酸在水热条件下反应使配体发生羟基化衍生成2，6-二羧基苯酚，并组装出2个含衍生配体的配位聚合物。

In complexes 8～16 synthesized by hydrothermal method, most of the ligands adopt multidentate coordination modes joining several lanthanide ions into high-dimensional coordination polymers. And changing of 5-substituting group on isophthalic acid has a little effect on the coordinated abilities of the meta-carboxyl groups.

水热法制备的配合物8～16中，配体多采取多齿配位模式桥连多个稀土离子，形成高维配位聚合物，同时由于羧基氧原子和稀土离子的强的键合力，间苯二甲酸的5位取代基的变化对间位羧基的配位能力的影响不大。

METHODS: Rat mesenchymal stem cells at passage 3 were obtained under sterile condition, and divided into groups A-F. In group A, iodine ion was not added. In groups B-F, iodine ion at mass concentrations of 2, 55, 90, 125 and 2 500 mg/L was added respectively. An additional blank control group was established, and simultaneously the cells were induced into neuron-like cells with dimethyl sulphoxide.

无菌条件下取大鼠第3代间充质干细胞，分为A~F组：A组不加碘离子，B~F组中分别加入质量浓度为2，55，90，125和2 500 mg/L的碘离子，另设空白对照组，同时加化学诱导剂二甲基亚砜向神经元方向诱导分化。

By using multi-dimensional nuclear magnetic resonance method we have studied the folding mechanism of staphylococcal nuclease in vitro; the tertiary interactions for folding of SNase fragments into native-like conformation; the interaction between SNase N- and C-terminal subunits; the relationship of enzyme activity with folding and dynamic states of SNase; the structural properties of enzyme protein while exert its function. We have studied the internal motions of thermophilic Archaea protein Ssh10b and mechanism of its heat-resistance using the NMR 1H-15N relaxation and H/D exchange methods. We have determined the 3D solution structure of human translationally controlled tumor protein TCTP and the Ca2+-binding site; determined the 3D crystal structure of human mitoNEET, a novel protein from distinct groups of iron-sulfur proteins; determined the 3D solution structure of a novel chromatin protein Cren7. Determination of SNase-DNA and Archaea protein-DNA complex structures are in progress.

运用异核多维核磁共振方法研究了金黄色葡萄球菌酶体外折叠机制，酶蛋白片段体外折叠成类天然溶液三维构象的三级相互作用力，酶蛋白亚基间的相互作用，酶蛋白的折叠以及内运动状态与酶活力的关系，酶蛋白发挥功能时的结构特性；运用NMR的1H-15N 驰豫和H/D交换方法研究了嗜热古菌蛋白质Ssh10b双体结构内运动特性，热稳定性机制；确定了人翻译控制的肿瘤蛋白TCTP蛋白的溶液三维结构及其钙离子的结合部位；确定了一类新的铁硫蛋白家族蛋白人线粒体膜上mitoNEET蛋白的晶体结构；确定了一个新型的染色质蛋白Cren7的溶液三维结构；正在研究金黄色葡萄球菌酶及嗜热古菌蛋白质与DNA复合体的溶液三维结构。

The ion concentrations were studied in both four snow pits on Hami Miaoergou FlatTopped Glacier and one snow pit on Haxilegen Glacier No.51 of Kuitun river in eastern Tianshan Mountain, and both snow pits were retrieved in 2004. The results show that the Ca2+, NO-3 and SO2-4, particularly Ca2+, are major ions in the snow of snow pits in both ablation and accumulation area and also in the ice of snow pits in accumulation area on Hami Miaoergou FlatTopped Glacier, where the relationships among major cation concentrations in snow of snow pits can be revealed by ion concentrations in the ice of snow pits, but the correlation between ion concentrations in the snow of snow pits and elevation is not obvious, which probably can be attributed to the narrow span of elevation and sparse snow pits on glacier. However, the good correlation between ion concentrations in the ice of snow pits and elevation indicates that the elution process weakened gradually with the elevation rise and temperature decrease.

对2004年获取的天山奎屯河哈希勒根51号冰川1个雪坑和哈密庙尔沟平顶冰川4个雪坑的离子浓度特征进行了研究，结果表明：Ca2+、NO-3和SO42-是哈密庙尔沟平顶冰川雪坑雪层和积累区雪坑底部冰中的主要离子（尤其是Ca2+），其雪层中的主要阳离子关系可在底部冰中得以较好的反映，但雪层中各离子浓度与海拔的相关性不明显，可能与海拔的跨度较小和挖取的雪坑较疏有关；雪坑底部冰中的离子浓度与海拔间明显的相关性说明淋融作用随着海拔升高、气温降低而逐渐减弱。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。