福莫尔

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Representing some of the most influential models including Kate Moss, Jourdan Dunn, Cindy Crawford, Lily Cole, Sophie Dahl, Eva Herzigova, Alek Wek, Carla Bruni and boys Trent Ford, Sam Branson and Matthew Avedon, Storm began life in 1987 in a tiny house in Battersea.

约占最有影响力的车型包括凯特莫斯，卓丹邓恩，辛迪克劳馥，百合，科尔柔达尔，爱娃赫兹高娃， Alek Wek ，卡拉布鲁尼和男孩特伦特福特，三布兰森和马修埃夫登，风暴开始于1987年生活在一个小家中巴特西。

Active in contemporary music since studying at Mills College, California,with composers Darius Milhaud,Leon kirchner,and Leon Kirchner,and Lawrence Moss, she also holds graduate degrees in musicology form Columbia University.

早年就读于加利福尼亚州米尔斯大学，学生时期就同作曲家达利斯·米哈德，莱昂·柯西纳和劳伦斯·莫斯合作，活跃于当代音乐领域。谢丽尔同时拥有哥伦比亚大学音乐学硕士学位。

Gibson's first "semi-acoustic" the ES-335, which was neither totally solid nor fully acoustic, is the guitar of choice used by many famous guitarists such as Andy Summers, Elvin Bishop, Lee Ritenour, Jay Graydon, Robben Ford, Freddie King, John McLaughin, Jimmy Page, Chuck Berry, Tony Mottola, Johnny Rivers, Jack Wilkins, Bono, Grant Green, Eric Clapton, Stevie Ray Vaughan, Alvin Lee, BB King, Emily Remler, Otis Rush, Pete Townshend, John Lee Hooker, and Larry Carlton.

吉布森的第一个"半声"的ES - 335，这既不是完全稳固的，也不可能完全声，是由诸如安迪萨默，埃尔文主教，李莱特诺，杰伊格雷顿，罗本福特，弗雷德金许多著名吉他手使用的选择吉他约翰McLaughin，吉米佩奇，查贝里，托尼莫托拉，约翰尼河流，杰克威尔金斯，波诺，格兰特绿色，埃里克克莱普顿，史蒂维雷沃恩，阿尔文李，比比金，埃米莉Remler，奥的斯拉什，皮特汤森，约翰李胡克，和拉里卡尔顿。

He was raised in Vancouver, British Columbia and then moved to the family home on Morrill Street in Port Coquitlam, British Columbia, with his brother Fred, his younger brother Darrell, and his sister Judith.

福克斯。他在不列颠哥伦比亚的温哥华市，后来迁往科奎特勒姆港的莫瑞尔街与哥哥弗雷德，弟弟达瑞尔，妹妹茱蒂斯住在一起。

Meanwhile the chapter made some interesting analysis of the relationship between Marx and Aeschylus, Spartacus, Martin Luther, Dante, Cervantes, Shakespeare, Balzac, Danidl Defoe, Voltaire, Rousseau, Diderot, Goethe, Schiller, Immanuel Kant, Fichte, Hegel, Feuerbach, Hess, Friedrich Engels, Saint-Simon, Fourier, Robert Owen, P. Trémaux,Comte, N.

同时本章还就埃斯库罗斯、斯巴达克、马丁·路德、但丁、塞万提斯、莎士比亚、巴尔扎克、笛福、伏尔泰、卢梭、狄德罗、歌德、席勒、康德、费希特、黑格尔、费尔巴哈、赫斯、恩格斯、圣西门、傅立叶、欧文、达尔文、比·特雷莫、孔德、弗列罗夫斯基等人与马克思的关系做了有趣的分析。

Defour, having been spared the red card Moyes demanded, was allowed to collect the ball 25 yards from goal and size up a shot, which Tim Howard spilled. Jovanovic was first to the rebound and after befuddling Baines he looped a perfect cross to the back post, where Witsel arrived to stab the ball into the net.

莫耶斯坚持认为应当被罚下场的德福尔，在距球门25码处从容得球，一脚试探性的射门被霍华德飞身挡出，约万诺维奇第一时间截得皮球，戏弄了贝恩斯之后弧线球传到后点，维策尔拍马赶到将球捅入网窝。

Local services such as refuse disposal, housing grants and parking control are still run by the 32 boroughs: Barking, Barnet, Bexley, Brent , Bromley, Camden, Croydon, Ealing, Enfield, Greenwich, Hackney, Hammersmith and Fulham, Haringey, Harrow, Havering, Hillingdon, Hounslow, Islington, Kensington and Chelsea, Kingston-upon-Thames, Lambeth , Lewisham, Merton, Newham, Redbridge, Richmond-upon-Thames, Southwark, Sutton, Tower Hamlets, Waltham Forest, Wandsworth, and Westminster.

当地服务如垃圾处理，住房补助及停车管制，仍是由以下32个区县管辖：巴金，巴奈特，贝克思雷，布伦特，布罗摩里，坎登，克罗伊登，伊令，埃菲尔德，格林威治，哈克尼，汉莫史密斯和富勒姆，哈林盖，耙，海沃林，惠灵顿，洪斯洛，伊斯林顿，金斯顿和切尔西，金斯顿在泰晤士，朗伯斯，琉易舍姆，墨顿，纽汉，雷德布里奇，里士满在泰晤士，南华克，萨顿，哈姆雷特塔，沃尔瑟姆福雷斯特，旺兹沃思，威斯敏斯特。

These besuited men are talent agents and their stomping ground is the stretch of Wilshire and Santa Monica Boulevards that links Beverly Hills with the skyscrapers of nearby Century City, the business district built on land formerly owned by the nearby 20th Century Fox studio.

这些西服革履的人是明星经纪人，他们出没于将贝弗利山和附近世纪城的摩天大楼连接起来的威尔希尔大道和圣塔。莫妮卡大道一带。世纪城商业区是在20世纪福克斯公司(20th Century Fox)制片厂原有的土地上建造的。

"I tell you, sir, that two persons exist in you; the father has mourned sufficiently, now let the procureur fulfil his office."

&那么请发誓吧，&维尔福把莫雷尔和阿夫里尼的手拉在一起说，&你们发誓要保全我家的名誉，让我来为我的孩子报仇。&

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。