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MAG-Fc inhibits the differentiation and neurite growth of the NSCs, but has no effect on the proliferation.

MAG-Fc对神经干细胞向神经元干细胞的分化及其轴突的生长均有抑制作用,但对神经干细胞的增殖无明显影响。

Through immunocytochemistry study, we found that the α3 and/or α5 subunits of nicotinic acetylcholine receptor are predominantly expressed in the oxytocinergic neurons. Our finding is quite different from the conclusion of the British scholar Dr. Mason's work in 1980s. We also found in this study that, the α3 and/or α5 subunits of N-AChR can also be expressed on the axons of oxytocinergic neurons, and these immunoreactive axons could be seen projecting to the median eminence and further to the posterior end of neurohypophysis. In the hypothalamus of the 7-day postnatal pup rats, the expression patterns of α3 and/or α5 subunits of N-AChR are similar to that in adult rats.

我们用免疫组化的方法发现,α3和/或α5型烟碱型乙酰胆碱受体(Nicotinic acetylcholine receptor,N-AChR)亚单位在大鼠下丘脑OT能神经元中呈优势性的表达,这与上世纪八十年代英国学者Mason类似工作的结论不一致;而且我们还发现α3和/或α5型N-AChR亚单位还表达在OT能神经元的轴突,此阳性免疫反应的轴突一直延续到正中隆起和神经垂体的末端;在新生7天大鼠的下丘脑,α3和/或α5型N-AChR亚单位的分布类似成年鼠。

The expression and axonal transport of pituitary adenylate ecelase-activing polypeptide was reported, The number of neurons immunoreactive for PACAP increased markedly within the nodose ganglion during a 24-48h culture period, PACAP was found to axonally transported and accumpulated at the site of a crush injury.

另有一个研究,是调查在体外培养的鼠迷走神经中垂体腺苷酸环化酶激活多肽的表达和轴突输送,提出在24-48小时的培养期,PACAP免疫反应性神经元的数目在结节神经节内显著地增加,PACAP参与轴突输送中并堆积在受损部位,在这部位被释放。

Bladder contraction was very quickly initiated by trains of stimuli(1 000 mV,10 Hz,2 s)of the right L5 dorsal root and bladder pressures increased rapidly to 65%of normal, and bladder contraction induced by knocking the right patellar ligament was increased to 51%of normal through the new reflex arc in 4 canines after 6 months of operation.

体神经的运动传出支通过轴突再生能够长入自主神经的副交感性纤维,并具有良好的传导运动兴奋的功能;利用截瘫平面以下健存的体反射,通过硬膜囊内神经根吻合的方法,可建立人工膀胱反射弧,实现患者的控制性排尿。

The somatic motor axons can be regenerated into the parasympathetic endoneurial tubes of autonomic nerve.Using the survived somatic reflex under the horizon of spinal cord injury to reconstruct the bladder autonomic reflex arc by intradural microanastomosis of ventral root is practical in the canine model and may have a potential of clinical application.

体神经的运动传出支通过轴突再生能够长入自主神经的副交感性纤维,并具有良好的传导运动兴奋的功能;利用截瘫平面以下健存的体反射,通过硬膜囊内神经根吻合的方法,可建立人工膀胱反射弧,实现患者的控制性排尿。

The retinal nerve fibre layer is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography, giving a measure of axonal loss.

视网膜神经纤维层大致由视网膜神经节细胞的无髓轴突组成,并且可以用视觉相干X线断层扫描的方法来研究,可测定轴突的缺失。

The Anterior pagoda cell was identified by its axon arborizafion intracellularly filled with HRP. The axon of AP cell ran caudally to cross the midline in the neuropil where they bifurcated into two major branches that pass both the anterior and the posterior roots contralaterally.

对AP细胞进行电泳HRP胞内染料注射,作为对AP细胞的识别和验证电极所插的位置,并且观察了AP细胞的轴突树型,AP细胞的轴突分枝是走向对侧神经根。

The ability of showing the fracture and enlargement of geniculate fossa of facial nerve canal in axial and coronal imaging were compared.

比较轴面和冠状面图像对面神经管膝状神经窝扩大的显示情况。

It was achieved by intradural microanastomosis of the L6 ventral root to S2 ventral root. After axonal regeneration, the "patellar ligament-spinal cord center-bladder" reflex pathway was reestablished. The function of the reflex arc was observed by nerve electrophysiological experiment, detrusor electromyography experiment, urodynamic testing and HRP retrograde tracing before and in 8 months after the spinal cord was destroyed horizontally between S1 and S4 level. There was one case of conical SCI patient who had L1 fracture and paraplegia was received intradural microanastomosis of the L6 ventral root to S2 ventral root after Li fracture and paraplegia.

将Beagle犬L6前根近端与S2前根远端在硬膜内显微吻合,经一段时间的轴突再生后,建立&膝腱-脊髓中枢-膀胱&人工反射弧,术后8个月,在破坏S1~S4脊髓节段前后分别进行神经电生理、膀胱肌电图及尿流动力学和辣根过氧化物酶逆行示踪等检查;对1例L1压缩性骨折伴截瘫患者行右侧T11与52前根经腓肠神经移植硬膜内吻合术。

RESULTS The degenerative changes of nerve ending in Meissner's corpuscles were observed after 1 month of denervation, and the basic structure of the corpuscles had no obvious changes. After 3 months, the axons of corpuscles were disappeared, and the volume of corpuscles was shrunk. The basic structure of nerves was disappeared, and the lemmocyte and neurolemma plate were changed after 5 months.

结果 失神经1个月时触觉小体内的神经末梢已有溃变,触觉小体的基本结构无明显改变;3个月时轴突消失,触觉小体的体积开始萎缩;5个月时神经结构消失,膜细胞及其膜板亦开始改变;8个月时触觉小体内胶原纤维含量逐渐增多;12个月时触觉小体内膜结构与膜间基质完全消失,被胶原纤维代替。

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