神经萎缩的

BACKGROUND: After amyotrophic lateral sclerosis, motor neurons have changes in neural degeneration, but the precise mechanism is not clear.

摘要背景：肌萎缩侧索硬化后运动神经元存在神经变性改变，但其确切机制不明，内源性神经干细胞被认为是未来能有效解决此病的治疗方法之一。

The acute reaction of neurons against axon repellents is the collapse of growth cones, while the chronical reaction is the change of axon growth direction when they are cocultured with repellents secreting cells.

神经轴突对神经生长排斥因子的急性反应是生长椎的萎缩；将神经元与分泌排斥因子的细胞共同培养时引起的慢性反应是轴突生长方向的改变网。

NKCCl(superscript -/-) mice were deaf and demonstrated difficulties in maintaining their balance. NKCC1 mice exhibited a marked atrophy of the stria vascularis, contraction of the endolymphatic compartments and collapse. CONCLUSION: NKCCl channel plays a critical role in potassium homeostasis of endolymph in the inner car.

光镜下NKCCl野生型小鼠和NKCCl杂合子小鼠的耳蜗解剖结构无明显异常；NKCCl突变纯合子小鼠的耳蜗出现前庭膜塌陷、内淋巴腔缩小而致中阶完全消失，并有血管纹萎缩、Corti器缺失、螺旋神经节萎缩；且球囊和椭圆囊膜迷路失去正常结构并出现塌陷等病理改变。

Their ages ranged 6 to 13 years. Their EEGs were characterized by continuous spike-and-wave discharges during non-rapid eye movement sleep, accounting for 85%-100% of the period of NREM sleep. Clinically, these children had various types of epileptic seizures and exhibited different degrees of neuropsychiatric impairments, language dysfunction, and/or behavioral disturbances. Neuroimaging abnormalities were found in 6 cases, including atelencephalia or atrophy, gray matter heterotopia and leucomalacia. CONCLUSIONS: This study indicates the characteristics of CSWS syndrome in clinical manifestations, EEG and neuroimaging examinations.

结果：9例患儿的视频脑电图结果符合CSWS诊断标准，年龄6~13岁，脑电图表现为棘慢复合波在整个非快速眼动睡眠期几乎持续存在，其放电时间占整个NREM期的85%~100%；临床上患者表现不同类型的癫癎发作，在神经精神方面存在不同程度的损害，存在言语和/或行为障碍；其中6例患儿显示有神经影像学异常，包括脑发育不全或萎缩、灰质异位、脑白质软化等。

In many cases, ephrins act as negative regulators that stimulate growth cone collapse and inhibit neurite outgrowth.

在许多例子中，ephrin对於神经的发育扮演著负向的调控者，它们能够刺激神经生长锥的萎缩而抑制神经纤维的生长。

Neurotomy law refers to the leg turnips removed to connect the gastrocnemius nerve, so that the principle is the same as shrinking the muscles, so thin legs, but once the nerve repair broken unlikely to form a permanent injury.

神经切断法指的是切除连接萝卜腿腓肠肌的神经，原理一样是让肌肉日渐萎缩，让小腿变细，不过一旦神经断了恐难修复，形成永久性伤害。

At the same time, PDI can act as molecular chaperone that help the denatured proteins refold and inhibit the aggregation of the denatured proteins.

在神经变性疾病如帕金森症、阿尔兹海默症、肌萎缩侧索硬化症、多聚谷氨酰胺疾病中，PDI可通过抑制错误折叠蛋白的聚集以及遍在蛋白化，起到神经保护作用。

AbstractWe present the early diagnosis method of agerelated macular degeneration , and characterize various pathological changes arising in the development of AMD, such as drusen, chorioretinal mapshrinking, retinal pigment epithelial atrophy, choroidal neovascularization, retinal pigment epithelium and neural epithelial detachment, and so on. We analyze its images by using optical coherence tomography.

本文给出了一种老年性黄斑变性（agerelated macular degeneration， ARMD ）的早期诊断方法，在 ARMD 的发展过程中出现的各种病理改变如玻璃膜疣、脉络膜视网膜地图状萎缩、视网膜色素上皮萎缩、脉络膜新生血管、视网膜色素上皮/神经上皮脱离等，用光学相干断层成像技术（optical coherence tomography，OCT）对其进行图像分析。

AbstractWe present the early diagnosis method of agerelated macular degeneration , and characterize various pathological changes arising in the development of AMD, such as drusen, chorioretinal mapshrinking, retinal pigment epithelial atrophy, choroidal neovascularization, retinal pigment epithelium and neural epithelial detachment, and so on.

本文给出了一种老年性黄斑变性（agerelated macular degeneration，ARMD）的早期诊断方法，在ARMD 的发展过程中出现的各种病理改变如玻璃膜疣、脉络膜视网膜地图状萎缩、视网膜色素上皮萎缩、脉络膜新生血管、视网膜色素上皮/神经上皮脱离等，用光学相干断层成像技术（optical coherence tomography，OCT）对其进行图像分析。

RESULTS The degenerative changes of nerve ending in Meissner's corpuscles were observed after 1 month of denervation, and the basic structure of the corpuscles had no obvious changes. After 3 months, the axons of corpuscles were disappeared, and the volume of corpuscles was shrunk. The basic structure of nerves was disappeared, and the lemmocyte and neurolemma plate were changed after 5 months.

结果 失神经1个月时触觉小体内的神经末梢已有溃变，触觉小体的基本结构无明显改变；3个月时轴突消失，触觉小体的体积开始萎缩；5个月时神经结构消失，膜细胞及其膜板亦开始改变；8个月时触觉小体内胶原纤维含量逐渐增多；12个月时触觉小体内膜结构与膜间基质完全消失，被胶原纤维代替。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。