神经膜细胞

The notable proliferation was not observed by eyes in the local of injection. The infiltration of inflammation cells and mild proliferation of fibrocyte around dura mater was observed by HE stained in 4 and 8 weeks after injection. Infiltration and exudation of inflammation cells was observed by HE stained in epidural nerve root. Compared with group A, no changes of group B, C and D were observed under specific stained. Proliferation of type Ⅱ collagen fibers around dura mater was seen under immunohistochemical stained in 4 and 8 weeks after injection. There is no significant demyelination changes under LFB stained. The thickness and shape of the myelin sheath in epidural nerve root was not regular under transmission electronic microscopy in 4 and 8 weeks after injection. Fibroblast was also seen there. In nerve endometrium, macrophage could be seen under TEM, myelinated nerve fiber changed significantly, but nonmyelinated nerve fiber changed mildly. When 8 weeks, the changes of group D is smaller than the group B and C.

给药局部肉眼观察未见明显的纤维组织增生；HE染色可见B、C、D三组给药后四周及八周时硬膜内外均有炎细胞浸润，纤维细胞轻度增生，硬膜外神经根内有炎细胞浸润及炎性渗出；特殊染色B、C、D三组同A组相比未见有脊髓及神经根的改变；免疫组化染色，给药后四周及八周时，硬膜内外均有Ⅱ型胶原纤维增生；固兰染色B、C、D三组未见有明显脱髓鞘改变，与A组相比无明显异常改变；电镜观察B、C、D三组在给药后的四周及八周时，表现为硬膜外神经根内髓鞘厚薄不一，形状不规则，可见成纤维细胞，神经内膜中可见有巨噬细胞；粗大的有髓神经纤维变化明显，无髓神经纤维受累较轻；八周时电镜下D组改变较B、C两组为轻。

Out of 9 animals with hearing loss had these autoantibodies; Endolymphatic hydrops, vasculitis of modiolus, degeneration of the neural elements, distension and thicking of the Reissner's membrane were seen in 46%, 78%, 12%, 21% of the experimental group ears respectively.

实验组32耳中内淋巴积水、蜗轴血管炎、螺旋神经节细胞空泡变性肿胀，前庭膜增厚、折叠的发生率分别是46%、78%、12%、21%，听力损害的12耳均有不同程度的上述病理变化。

Results The choroid plexus, hypophysis, area postrema and pineal body, namely, circumventricular organs and ependyma as well as pia mater layers were stained by the HRP reaction products.The HRP reaction products were observed in the tissue space of membrane mucosa nasi, around the fila olfactoria and venules, and within the venules under the light microscopy and electron microscopy, also. Scintillation count showed that the radioactivity of the CVOs was higher than that of the background. The radioautography showed that the scattered grains of silver existed within the cells of neurocyte layer also.

结果 在脑室周围器官及脑室周围室管膜、软脑膜层有HRP反应产物的聚集，在鼻中隔的鼻粘膜下组织间隙、嗅丝周围间隙及静脉周围和管腔内也可见到HRP反应产物；液闪计数显示，大白鼠的脉络丛、脑垂体、最后区、松果体等脑室周围器官放射性活度明显高于本底；放射自显影显示大白鼠脑组织神经层细胞内有散在分布的银颗粒。

To shed light on these issues, Kuo and his colleagues genetically engineered neural stem cells and ependymal cells in the SZ of newborn mice in such a way that they lacked two key proteins, named Numb and Numblike.

为了阐明这些问题，Kuo和他的同事对新生小鼠的SZ神经干细胞和室管膜细胞进行这样的一种遗传工程学处理，敲掉2个关键蛋白，分别命名为Numb 和 Numblike。

Histochemical study showed animals perfused with Ad-LacZ had intense X-Gal staining in the spiral limous, spiral ligament, spiral ganglion cells and the organ of corti in the perfused cochlea.

然后进行基底膜铺片和耳蜗石蜡切片观察发现，在内、外毛细胞，螺旋韧带，血管纹，Corti氏器以及螺旋神经节细胞均可被染成兰色。

Objectives The purpose of this study was to evaluate the therapeutic effects and mechanisms of high thoracic epidural blockade on patients with idiopathic dilated cardiomyopathy by detecting heart rate variability , arrhythmias, neurohumoral factors, mortaliity of DCM patients and apoptosis in dilated cardiomyopathy mouse.

目的 研究高位硬膜外阻滞对原发性扩张型心肌病患者心率变异性、心律失常、神经内分泌细胞因子、病死率的影响，对扩张型心肌病大鼠心肌细胞凋亡的作用，旨在探讨该方法治疗原发性扩张型心肌病的疗效及机制。

This is a retrospective analysis of 194 patients with primary malignant brain tumor, who registered between January 1, 1970 and December 31, 1979 in cancer registration, Cancer Therapy Center, Veterans General Hospital, Taipei, Taiwan, R.O.C. There were 36 cases of glioblastoma multiforme, 86 cases of malignant astrocytoma (grade Ⅲ and a few grade Ⅱ), 22 of medulloblastoma, 12 of oligodendroglioma, 11 of ependymoma or ependymoblastoma and 27 cases of other types. There were 141 male cases with ages ranging from ito 81 years with a mean of 33.3±19.3 and median of 34 years.

自1970年1月至1979年12月台北荣民总医院癌病治疗中心癌病登记组共登记了194例原发恶性脑瘤其中多形神经胶母细胞瘤有36例，第二级及第三级星细胞瘤有86例，神经管胚细胞瘤有22例，间胶质母细胞瘤有12例，室管膜瘤或室管膜胚细胞瘤(ependy-moblastoma)有11例，其他有27例。

About 48%(90/194) were below 29 years of age. Ninety-nine of 194 cases had either radiotherapy alone or supplementary treatment with radiotherapy following surgery. We analyzed multiple prognostic factors. The factors of importance included postoperative radiotherapy; female in glioblastoma multiforme; the primary tumor dose above 5000 rads and/or whole brain irradiation in malignant astrocytoma and glioblastoma multiforme; the primary tumor dose above 4500 rads in ependymoma, medulloblastoma and oligodendroglioma; and spinal axis irradiation above 2000 rads in ependymoma and medulloblastoma that produced a better prognosis than in other groups.

男与女之比例为2.7比1，年龄分布自1至81岁，平均年龄33.3±19.3岁，中值年龄为34岁，29岁以下占48%(90/194)，其中99例单独或手术后辅以放射腺治疗，分析同种脑瘤的预后因素，其中多形神经胶母细胞瘤有手术后放射线治疗或女性，多形神经胶母细胞瘤合并星细胞瘤原发肿瘤剂量5000雷得以上或曾全颅腔照射，神经管胚细胞瘤，间胶质母细胞瘤，及室管膜瘤原发肿瘤剂量4500雷得以上，室管膜瘤及神经管胚细胞瘤有脊轴照射2000雷得以上预后均佳，且统计上有显著的差异。

While the tissue spaces surrounding a few blood vessels wasAl and Fg positive,no Al or Fg positive cells were observed.In antemortem injurygroup,diffuse subarachnoid hemorrhage,cerebral edema,swelling or pyknotic neu-rons could be observed.The axons showed irregular swelling and disconnection at1～3h,marked swelling and disconnection at 6h,and retraction ball at 15h whichwas more remarkable at 24h after injury.The space between myelin sheaths andaxons was increased at 3～6h after injury.Tortuous and wavelike myelin sheathswhich adhered on axons incompletely,or even peeled off could be found from 15hto 24h after injury.Perinuclear lysis of Nissl bodies began at 24h after injury.Thenumber of GFAP positive cells in cerebrum and brain-stem increased significantlyfollowed by decrease,and then increased again,but the time courses of the changesin different areas of brain were not same.Al and Fg positive neural cells,mainlysurrounded blood vessels,with diffuse or peripherally distributed positive matter incytoplasm could be observed at 0.5h after injury.The number of Al or Fg positivecells and the intensity of immunoreaction increased with the time of injury.The areaof SYN positivity in medulla oblongata and pons decreased notably 3～6h afterinjury,then return to normal levels and continued to 24h after injury.

生前损伤组，可见广泛蛛网膜下腔出血，脑组织水肿，神经细胞肿胀，晚期神经元固缩；伤后1～3h见部分神经轴突不规则增粗、断裂，伤后6h断端膨大，伤后15h可见收缩球，至伤后24h更为明显；伤后3～6h可见部分神经髓鞘与轴突之间的间隙增宽，伤后15h髓鞘明显曲折，不完全附着在轴突两侧，甚至剥脱，持续到伤后24h；核周尼氏体减少在伤后24h才开始出现；同一部位的GFAP阳性细胞数目随损伤时间发生改变，先增多（最早在伤后0.5h），达到高峰后减少，其后又有增多趋势，但不同部位的GFAP阳性细胞数目增减的时间过程不尽相同，同时，大脑中的GFAP阳性细胞数目也有改变；伤后0.5h，可在脑干组织中见到Al和Fg阳性神经细胞，主要位于血管周围，阳性物在胞浆中呈弥散性分布，但部分细胞的阳性物仅分布于靠近胞膜的胞浆中而呈环状，随损伤时间延长，阳性细胞数目增多，反应强度增加；伤后3～6h，延髓及桥脑中的SYN阳性物面积减少，其后恢复到正常水平，并持续到伤后24h。

Results The results showed hyper fluorescence was located in tectorial membrane, spiral ganglion, organ of corti. There were less intensity of fluorescesce among the atria vascularis.

结果 KCC2的阳性表达部位主要分布在耳蜗的盖膜、柯蒂器、螺旋神经节细胞以及前庭壶腹嵴顶部的毛细胞，耳蜗螺旋韧带及血管纹上KCC2为弱阳性表达。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新