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RESULTS: hMSC had good homogeneousness and immunological reaction after implantation.

结果: 第5代呈集落生长的hMSC,均一性好。hMSC可在脑内存活6周以上;随着时间的延长,hMSC在脑内迁移的范围越来越大;间接免疫荧光表明hMSC在大鼠脑内表达人神经元特异性烯醇化酶、神经丝蛋白和胶质纤维酸性蛋白;模型鼠的肢体运动功能有明显改善。

Objective: To study the effect of "Yiqitiaoxue, fubenpeiyuan" Acup Therapy on selective neuron lost of Senile Accelerated Mouse P8, a model of AD, treated with acupuncture. Observe the number and sharp of neuron in the hippocampus and the cortex of temporal lobe, activation and accrementition of horizontal cell, as well as the expression of apoptosis relative protein. Discusse the possible mechanism of acupuncture in neuroprotective effect.

目的:以快速老化模型小白鼠SAMP8为阿尔茨海默病(Alzheimer&s disease, AD,老年性痴呆)动物模型,通过观察针刺对该小鼠海马和颞叶皮质神经元数量以及神经元形态、星形胶质细胞的活化增生、凋亡相关蛋白的表达的影响,研究&益气调血,扶本培元针法对AD选择性神经元丢失的干预作用及其机制,为针刺治疗AD提供神经病理学实验依据。

RESULTS The degenerative changes of nerve ending in Meissner's corpuscles were observed after 1 month of denervation, and the basic structure of the corpuscles had no obvious changes. After 3 months, the axons of corpuscles were disappeared, and the volume of corpuscles was shrunk. The basic structure of nerves was disappeared, and the lemmocyte and neurolemma plate were changed after 5 months.

结果 失神经1个月时触觉小体内的神经末梢已有溃变,触觉小体的基本结构无明显改变;3个月时轴突消失,触觉小体的体积开始萎缩;5个月时神经结构消失,膜细胞及其膜板亦开始改变;8个月时触觉小体内胶原纤维含量逐渐增多;12个月时触觉小体内膜结构与膜间基质完全消失,被胶原纤维代替。

These results can lead to the following conclusion:〤GRP synthesized by the motoneurons may be a self-serving neurotrophic factor after axotomy.(2) CGRP may serve as a "injury signal" activating both the central and peripherical gli

本研究结果提示,运动神经轴突损伤后,运动神经元合成分泌的CGRP对神经元自身具有直接的神经营养作用,CGRP还可以作为损伤神经元分泌的&损伤信号&激活中枢和外周胶质细胞,从而为运动神经元的存活和轴突再生创造有利的微环境。

This research has proved that an artificial neural network is capable to differentiate the reactional enhancement of malignant intracranial gliomas in postoperative MR images and the enhancement caused by tumor residual. As a innovative differentiation approach, it requires further studies and researches to determine its applicability in practice, including the increase of training samples, image description standardization, effects to doctoral diagnosis, as well as parameter optimization. With improvements in these elements, the performance of the network will be optimized.

本研究成功地证明了人工神经网络能够鉴别颅内恶性胶质瘤术后磁共振图像的反应性强化与肿瘤残存所致的强化,为解决二者的鉴别这一复杂问题提供了一个新的方法,但是本研究只是初步的应用探讨,能否在实际中应用,还有待于进一步的研究,如训练样本的增加、图像描述的规范化、对医师诊断影响程度、参数的优化等,网络的性能会不断完善和提高。

This research has proved that an artificial neural network is capable to differentiate the reactional enhancement of malignant intracranial gliomas in postoperative MR images and the enhancement caused by tumor residual. As a innovative differentiation approach, it requires further studies and researches to determine its applicability in practice, including the increase of training samples, image de脚本ion standardization, effects to doctoral diagnosis, as well as parameter optimization. With improvements in these elements, the performance of the network will be optimized.

本研究成功地证明了人工神经网络能够鉴别颅内恶性胶质瘤术后磁共振图像的反应性强化与肿瘤残存所致的强化,为解决二者的鉴别这一复杂问题提供了一个新的方法,但是本研究只是初步的应用探讨,能否在实际中应用,还有待于进一步的研究,如训练样本的增加、图像描述的规范化、对医师诊断影响程度、参数的优化等,网络的性能会不断完善和提高。

Morphologically similar lesions from 26 patients (mean age, 62 y; range, 46 to 88 y; male/female ratio, 10/16) were retrieved from surgical pathology and consult files. Clinical and endoscopic data were obtained, and immunohistochemistry for S-100 protein, glial fibrillary acidic protein, neurofilament protein, epithelial membrane antigen, claudin-1, CD34, smooth muscle actin, and KIT was performed. The findings were compared with those in mucosal biopsies of 5 submucosal neurofibromas from NF1 patients.

我们从外科病理和档案库里调取了26例病变形态相似的病例(患者平均年龄62岁,范围:46至88岁,男女比例:10/16),得到了他们的临床及内窥镜资料,并给它们都做了S-100蛋白、胶质纤维酸性蛋白、神经丝蛋白、上皮膜抗原、闭合蛋白-1(claudin-1)、CD34、平滑肌肌动蛋白和KIT的免疫组化,所得的结果都与5例NF1患者粘膜下神经纤维瘤的粘膜活检的结果相比较。

It was observed by Nissl and enzyme histochemistry staining that exogenous GDNF decreased lesion-induced motor neuron death in lateral nucleus of spinal anterior horn and the changes in activity of cholinesterase and acid phosphatase in spinal cord and sensory ganglions.

采用硅管套接大鼠切断的坐骨神经模型,局部给予胶质细胞源性神经营养因子,应用尼氏染色、酶组织化学染色方法,观察到外源性GDNF能减少脊髓修复侧前角运动神经元死亡的数目,降低脊髓前角运动神经元及脊神经节感觉神经元中胆碱酯酶及酸性磷酸酶变化的幅度。

Objective: Comparative and extended research among the newly found cell, microglia cell and atypical cell in the rat organ of Corti after aminoglycoside intoxication; to further explore quality, origin, and the relationship between the newly found cell and the neural stem cell or nestin progenitor cell.

目的:对大鼠耳蜗药物损伤后出现的新细胞与小胶质细胞、非典型细胞进行比较和扩展研究,探讨新细胞的代表性及其起源、转归、以及与神经干细胞或nestin前体细胞的关系。

The invasive behaviors,which have still been the major problem for neurosurgeons,was demonstrated to be the main reason for failures of current therapeutic strategy of gliomas treatment.it is helpful in therapy of gliomas to improve our understanding of the mechanisms of gliomas progress.

脑胶质瘤的高侵袭性是神经外科医师面临的难题,目前在临床上仍无好的治疗方法,针对侵袭性机制的深入研究可能是其解决途径。

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In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是,在否定句或疑问句里,这种带有"do"的方法表达的效果却没有什么强调的意思。

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