神经胶质的

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Our study suggests that, for patients with gliomas treated by GKS, the post-treatment fluorodeoxyglucose-positron emission tomography could be used to predict response to treatment.

我们的研究显示对经过加马刀放射手术治疗的神经胶质瘤的病人而言，治疗后的氟-18去氧葡萄糖正子断层摄影可以用来预测治疗效果。

However, the downregulation of CD81 expression involved in the reattachment showed a delay to that of the proliferation index.

通过本研究，我们证明：正常大鼠的视网膜可以表达CD81，视网膜的神经胶质细胞和色素上皮细胞可能是表达CD81的主要细胞类型。

Because glial cell activation could also be involved in the development of opioid tolerance in rats, the authors studied the antinociceptive effects of ibudilast and morphine in different models of coadministration.

由于大鼠神经胶质细胞的激活也被证实与阿片样物质耐受性的产生有关，作者研究了异丁司特和吗啡在不同的共同给药模型中的镇痛作用。

We found that malignant human glioma cells constitutively expressed matrix metalloproteinase-2 (MMP-2), and the MMP-2 activities were correlated well with their malignancies.

我们发现恶性人类神经胶质瘤细胞会持续的表现matrix metalloproteninases-2 (MMP-2)，而且MMP-2的活性和肿瘤细胞的恶性度有密切的关系。

In pure cultured neuron, the inhibitory effect of 0.5mmol/L L-NNA on theincrease of LDH leaking after exposure of H/R and SIN-1 had also no statistical significance, but it could inhibit significantly the above index in mixedly cultured cerebral cortex neuron and glia.

在单纯培养神经细胞中0.5mmol／LL－NNA对H／R＋SIN－1导致的LDH漏出率增加仍无显著抑制作用，但可显著抑制H／R引起的混合培养的神经细胞和神经胶质细胞的LDH漏出率。

Curran and a team of American and Canadian researchers, in conjunction with the Philadelphia-based Radiation Therapy Oncology Group, a federally-supported clinical trials organization, found that among 289 patients with either anaplastic oligodendroglioma or anaplastic oligoastrocytoma receiving either a combination of three chemotherapy drugs with radiation or radiation alone, those whose tumors had deletions in chromosome locations 1p and 19q tended to live nearly two and a half times longer than those patients without the missing chromosome portions.

临床癌症杂志》上周报道，卡仑博士和由美国、加拿大研究人员组成的科研小组，联合了总部设在费城的由联邦政府支持的临床实验组织－美国放射肿瘤学协作组，进行了研究。289名病人患有退行性少树突神经胶质瘤或退行性少星细胞瘤，研究发现，这些病人在接受三种化疗药物结合放疗或者只接受放疗后，其中染色体缺乏1p 和19q 的病人比那些不缺乏的病人多存活了2倍半的时间。

Methods: Two tag SNPs (rs2439322 and rs16879809) of NRG-1 in 254 schizophrenia trios were genotyped by using PCR-RFLP, and LD, TDT and HHRR were analyzed by using EMLD, UNPHASED and TRANSMIT softwares.

目的 ：探索位于 8 号染色体短臂（ 8p ）的神经胶质细胞生子因子 1 （ NRG-1 ）基因与精神分裂症易感性之间的关系；探索同样位于 8p 的 NRG-1 基因与 ASAH1 基因之间的相互作用。

The expression of N-methyl-D-aspartatereceptor subunit2B in the passaged NSCs was determined by im-munocytochemistry and Western blot.

谷氨酸是体内一种主要的兴奋性氨基酸，它的过度释放可通过NMDA受体导致神经元和神经胶质细胞的死亡［2］。

The location of the glioma must also be considered when deciding treatment. Senator Kennedy's tumor is in the left parietal lobe of the brain.

当决定治疗方案的时候，必须要考虑神经胶质瘤的位置。K议员的肿瘤在脑体壁圆形突出物的左侧。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。