神经胶质

There was an obvious increase of insulin receptor gene and protein in the cerebral ischemia reperfusion tissues in rats. The positive cells such as neuron, neuroglia cells, vascular endothelium cells possibly participated in regulating the processes of energy metabolism of cells and neovascularization. It implied that the high expressions of insulin receptors in vascular endothelium cells in ischemic zones possibly participated in regulating the pathophysiological changes of the blood vessels in ischemic zones; The higher expressions of insulin receptors in different cells were possibly one of the self-protective machanisms in which the ischemic tissues confront the anoxemia injury.

脑缺血再灌注大鼠脑组织胰岛素受体基因和蛋白水平表达增加；半暗带区神经元、部分神经胶质细胞及血管内皮细胞等阳染细胞可能参与脑缺血后组织细胞的能量代谢、促新生细胞形成等病理生理调节过程；胰岛素受体在缺血区血管内皮细胞高表达提示其可能在缺血区血管的病理生理变化中起某种调节作用；胰岛素受体在不同细胞中表达增高可能是缺血脑组织对抗缺血缺氧损伤的自身保护机制之一。

Abstract］ AIM: To study the cytotoxic effects of doxorubicin on apoptosis in glioma cell lines U343, U138, U373 induced by antihuman DR4/DR5 monoclonal antibodies (FMU1.4/FMU1.5) and the underlying mechanism.

摘 要］目的：探讨亚毒性剂量的阿霉素影响抗DR4、 DR5单克隆抗体 FMU1.4和FMU1.5诱导3株神经胶质瘤细胞株U343、 U138及U373凋亡的作用及可能的机制。

It has been reported recent years that the expression level of uPA system is closely associated with gliomas.

近年来发现uPA系统的表达水平与神经胶质瘤的恶性程度呈正相关。

The contents of Ca2+, CaM in blood and brain tissue were measured by atonic absorption spectrometry and radioimmunoassay.

颅脑损伤后神经元和神经胶质细胞膜系统的钙通道开放、细胞内钙超载、钙调蛋白激活，是导致继发性脑损害、脑水肿发生的关键［1］。

The location of the cleome glioma must also be considered when deciding treatment.

当决定治疗时神经胶质瘤的位置也必须考虑。

Remov al of the cleome a glioma from this area can result in speech problems and other disabilities.

移除这个区域的一个神经胶质瘤会导致一些语言问题和其他残疾。

Sniggers Seizures and headaches are comm on f irst signs of a cleome glioma .

发作和头痛是神经胶质瘤常见的第一现象。

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

In vitro experiments, the expression of cytochrome C in glial cells was detected by western blot and immunofluorescence cytochemistry.

体外实验中，免疫蛋白印迹法和免疫荧光细胞化学法测定大鼠神经胶质细胞细胞色素C的表达。

Objective: To investigate the dedifferentiation of glia cells and the expression of related molecules after optic nerve injury.

目的：研究视神经损伤后神经胶质细胞去分化的程度及相关分子的表达。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。