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神经细胞体

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Results There existed decreasing learning and memory function, increasing MAO-B activity from the cortex, hippocampus, and strium, elevating brain iron and aluminum levels with diminishing ferritin level, and karyopyknosis as well as neuron loss of hippocampus in the model mice.

结果 模型组小鼠学习记忆能力明显下降,大脑皮层、海马和纹状体MAO-B活力增加,脑铁水平明显升高,线粒体铁蛋白水平下降,而海马CA1区神经元核固缩和神经细胞丢失。

Bone marrow mesenchymal stem cells could differentiate into osteoblasts, adipocytes and neural like cells with osteoblast inductor (β-sodium glycerophosphate, dexamethasone, vitamin C), lipoblast inductor (dexamethasone, 3-isobutyl-1-methylxanthine, bovine insulin, indometacin) and serum-free medium inductor (dimethyl sulphoxide, butylated hydroxyanisole) respectively. Osteoblast marker (alkaline phosphatase, osteocalcin mRNA, calcium node), adipocyte marker (lipid droplet, PPAR γ-2mRNA) and neural cell-like marker (nissl body, neuron specific enolase, neurofilament protein) were respectively determined by the immunohistochemical method, polymerase chain reaction and immunocytochemical method.

分别采用成骨细胞诱导剂(β-甘油磷酸钠,地塞米松,维生素C)、成脂肪细胞诱导液(地塞米松,甲基异丁酸黄嘌呤,牛胰岛素,吲哚美辛)及二甲基亚砜和羟基丁酸苯甲醚无血清培养基诱导剂干预细胞向成骨、脂肪、神经细胞分化,经免疫组织化学染色、PCR、免疫细胞染色方法检测成骨标志物(碱性磷酸酶、骨钙素mRNA、钙结节)、脂肪标志物(脂滴、PPARγ-2mRNA)、以及类神经标志物(尼克氏体、神经烯醇化酶、神经丝蛋白)。

Results After in vivo transferring, neurocyte demonstrated strong positive signals with X-gal immunohistochemical staining.

结果:pHSVIRES-HPPE-LacZ在体感染大鼠中枢神经细胞后,用X-gal染色、RT-PCR和放射免疫检测方法均证实外源脑啡肽基因能有效表达。

In this study, the antioxidant components, antioxidative activity of five species of Davalliaceae plants and two polypodiaceae plants were investigated first by microtiter spectrophotometric and fluorescent methods. Then the protective effects of these plants on 6-OHDA-induced neuronal damage in B35 cells were investigated.

本实验采用俗名为骨碎补的五种骨碎补科与两种水龙骨科之近源植物作为实验材料,进行抗氧化成分含量与活性评估,并以离体方式探讨其对6-OHDA所诱导神经细胞损伤之保护作用与机制。

Results: The NOS positive cells are scattered in pterygopalatine ganglion, otic ganglion. The decreased density and the increased somatic size of the NOS positive cells of pterygopalatine ganglion, otic ganglion of rats was followed in rat's development and to the largest in adulthood.

结果:NOS神经细胞在翼腭神经节、耳神经节中总体呈均匀散在分布,从幼年到成年,密度呈逐渐下降趋势,而NOS神经元胞体大小逐渐增加,至成年时最大,直至老年无明显改变。

After sciatic nerve lesion 3 days, Schwann cells and other non-neuronal elements, begin to proliferate and express a great deal of neurotrophic factors incloding NT3, showing that NT3 may be transported retrogradely to neuronal soma, resulting in strong immunoreactivity.

损伤后3天,以雪旺细胞为主的非神经细胞开始大量增殖,雪旺细胞表达大量神经营养因子包括NT3,并逆向转运到达运动神经元胞体,这也导致免疫反应性的增强。

It suggests that Nolz-1 may play a specific role in striatal neurogenesis.

这建议Nolz-1可能在纹状体的神经细胞发生过程中扮演特定的角色。

Here, we describe the isolation, expansion, and in itro characterization of adult mouse tegmental NSCs and their differentiation into functional nere cells, including dopaminergic neurons.

在本文中,我们将展示成体大鼠被盖区NSCs的分离、扩增、体外鉴定及分化为功能性神经细胞的过程。

MethodsFocal cerebral ischemia was produced by permanent occlusion of the proximal of the right middle cerebral artery. The neurologic status of each rat was carefully evaluated at 24 h after surgery. The cerebral infarction numbers of neurons and nissls stains ,the water content were measured. Acute incomplete cerebral ischema was induced by ligaturing bilateral carotid arteries. Anoxia was produced by close normobaric hypoxia.

方法电凝大鼠一侧大脑中动脉造成局灶性脑缺血,观察脑血舒通对大鼠行为、大脑皮质内脑梗塞区神经细胞数量、尼氏小体含量、脑组织含水量的影响;采用结扎小鼠双侧颈总动脉形成急性脑缺血模型,并进行了小鼠常压耐缺氧实验,观察小鼠存活时间。

Through a second process known as autophagy, or "self-eating," nerve cells are able to defend against the toxic effects of aggregated forms of mutant huntingtin and ataxin-1 that have escaped the surveillance of the ubiquitin proteasome system.

通过称之为自噬或者自食的第二个过程,神经细胞能够防御那些逃避过泛素-蛋白酶体系统监视的突变亨廷顿蛋白和ataxin-1引起的毒性作用。

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