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Through a second process known as autophagy, or "self-eating," nerve cells are able to defend against the toxic effects of aggregated forms of mutant huntingtin and ataxin-1 that have escaped the surveillance of the ubiquitin proteasome system.

通过称之为自噬或者自食的第二个过程,神经细胞能够防御那些逃避过泛素-蛋白酶体系统监视的突变亨廷顿蛋白和ataxin-1引起的毒性作用。

Respiratory center is composed of several groups of nerve cells which produce and regulate respiratory movement in central nervous svstem.

呼吸中枢是指在中枢神经系统里产生和调节呼吸运动的神经细胞群。

This might be one of the mechanisms of retinal neuronal dysfunctions and vascular hyperpermeability.

PKC影响nNOS表达可能是视网膜神经细胞功能紊乱和血管通透性增高的机制之一。

Methods Animal model of epilepsy was established by pentylenetetrazol induction in rats.

采用戊四氮致疒间大鼠模型,检测癫疒间发作后神经细胞凋亡、NOS和NF- B的变化。

Methods Wistar middle cerebral artery occlusion reperfusion rat model was established by thread ligation. The infarction focus formation was observed by TTC staining. AIF expression in ischemia region of cortex of parietal lobe and nerve cell apoptosis degree in sham operation group, MCAO 90 min and reperfusion 0, 3, 6, 12, 24, 48 and 72 h were observed by TUNEL and immunohistochemistry technique.

应用线栓法建立Wistar大鼠大脑中动脉阻塞再灌注模型,TTC染色观察梗死灶的形成,应用原位末端标记和免疫组化技术分别观察大鼠假手术组、MCAO 90 min再灌注0、3、6、12、24、48、72 h时额顶叶皮层缺血脑区AIF表达及神经细胞凋亡程度的变化。

It can be an organic brain disease that causes permanent damage to nerves and nerve cells in the brain.

它可以成为有机脑疾病造成永久性的损害神经和神经细胞在大脑中。

Over the course of a year, they found that nearly all nerve cells in the olfactory bulb, responsible for smelling, had been replaced with new ones.

在一年的试验期内,他们发现嗅球内几乎所有的神经细胞都被新细胞取代了。

OBJECTIVE: To investigate the association between olfactory disturbance and ultrastructural mitochondrial changes in olfactory bulb neurons of aged rats in comparison with young rats.

目的:对衰老和年轻大鼠嗅球内神经元的线粒体超微结构进行对比观察,分析衰老大鼠嗅觉障碍与嗅球内神经细胞线粒体改变的关系。

MAIN OUTCOME MEASURES: Morphology change of spinal cord was detected by light microscope and electronmicroscope, secreted brain-derived neurotrophic factor was measured by immunohistochemistry and PT-PCR, and the combine behavioral score was used to assess the functional recovery of spinal cord. RESULTS: Immunohistochemistry result showed that OECs transplantation could partly reduce the number of apoptosis cells in spinal gray matter, delay cells reduction in spinal white matter, and accelerate the medullary sheath repair and regeneration.

主要观察指标:应用光学显微镜、电子显微镜观察脊髓形态的变化,采用免疫组织化学、PT-PCR 的方法检测脊髓组织脑源性神经营养因子的分泌,以改良的Gale联合行为评分法对脊髓功能进行评定,结果:免疫组织化学检测显示,嗅鞘细胞移植能部分改善大鼠脊髓灰质神经细胞的凋亡程度,延缓白质神经纤维的减少,促进髓鞘的修复与再生。

Each 1 μL site of spinal cord receiving 109 /L OECs at the speed of 1μL/ min. MAIN OUTCOME MEASURES: Morphology change of spinal cord was detected by light microscope and electronmicroscope, secreted brain-derived neurotrophic factor was measured by immunohistochemistry and PT-PCR, and the combine behavioral score was used to assess the functional recovery of spinal cord. RESULTS: Immunohistochemistry result showed that OECs transplantation could partly reduce the number of apoptosis cells in spinal gray matter, delay cells reduction in spinal white matter, and accelerate the medullary sheath repair and regeneration.

主要观察指标:应用光学显微镜、电子显微镜观察脊髓形态的变化,采用免疫组织化学、PT-PCR 的方法检测脊髓组织脑源性神经营养因子的分泌,以改良的Gale联合行为评分法对脊髓功能进行评定,结果:免疫组织化学检测显示,嗅鞘细胞移植能部分改善大鼠脊髓灰质神经细胞的凋亡程度,延缓白质神经纤维的减少,促进髓鞘的修复与再生。

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