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Naloxone can carry out its protective function to injuried neurocyte through alleviating neuronal cell apoptosis and hydrocephalus, and the effect was better as early as it used.

纳洛酮可通过减轻神经细胞的凋亡及脑水肿以实现对神经细胞损伤的保护作用,且早期使用效果更佳。

Objective To study c-fos expression and apoptosis after traumatic brain injury in rats, and to explore the role of apoptosis in the secondary brain injury ,and the relation between c-fos expression and neuroglial apoptosis.

目的研究创伤性脑损伤后脑组织c-fos表达及神经细胞凋亡,探讨神经细胞凋亡在脑继发性损害中的作用,及c-fos基因表达与凋亡的关系。

Objective To study cfos expression and apoptosis after traumatic brain injury in rats,and to explore the role of apoptosis in the secondary brain injury,and the relation between cfos expression and neuroglial apoptosis.

目的 研究创伤性脑损伤后脑组织cfos表达及神经细胞凋亡,探讨神经细胞凋亡在脑继发性损害中的作用,及cfos基因表达与凋亡的关系。

Objective To study c fos expression and apoptosis after traumatic brain injury in rats,and to explore the role of apoptosis in the secondary brain injury,and the relation between c fos expression and neuroglial apoptosis.

目的 研究创伤性脑损伤后脑组织c fos表达及神经细胞凋亡,探讨神经细胞凋亡在脑继发性损害中的作用,及c fos基因表达与凋亡的关系。

objective To study cfos expression and apoptosis after traumatic brain injury in ratsand to explore the role of apoptosis in the secondary brain injuryand the relation between cfos expression and neuroglial apoptosis.

目的 研究创伤性脑损伤后脑组织cfos表达及神经细胞凋亡,探讨神经细胞凋亡在脑继发性损害中的作用,及cfos基因表达与凋亡的关系。

The experimental study is to explore the effect about rhEPO on neuromotor function, secondary pathology change and expression of NTF and the apoptosis of neural cell, which administered at different time after traumatic spinal cord injury. The experimental study is devided into three parts: The first part The effect of rhEPO on NT-3 and NGF expression after traumatic spinalcord injury Objective Nerve growth factor and neurotrophic factor–3(NT-3) are chief members in neurotrophic factors family, which can promote nerve cell survival、growth and differentiation.

本研究拟在脊髓损伤后不同时间应用促红细胞生成素干预,探讨其对神经运动功能和继发性病理改变的保护作用及对神经营养因子表达和神经细胞凋亡的影响,共分为以下三个部分:第一部分脊髓损伤后促红细胞生成素对NGF、NT-3表达的影响目的:神经生长因子和神经营养因子-3(NT-3)是神经营养因子家族的主要成员,是机体产生的能够促进神经细胞存活、生长、分化的一类多肽或蛋白质因子。

To 26. 23, P <0. 01.CONCLUSION: Chlamys farreri is capable of increasing Bcl-2 protein and decreasing Bax protein in cerebral penumbra to brake the initiation of neuron apoptosis after ischemia-reperfusion and preserve neuronic function in penumbra.

扇贝多肽能够上调脑缺血半影区内抑制神经细胞凋亡的Bcl-2蛋白水平,同时降低半影区内诱导神经细胞凋亡的Bax蛋白的表达,从而在阻止脑缺血再灌注后细胞凋亡启动中起制动作用,保护脑缺血后半影区内神经元的功能。

Pharmacological activity test in vitro All target compounds and PFT-αwere assessed for their ability in vitro to protect PC12 cells against H2O2 induced apoptosis through MTT methods. The results suggested that compound 3a, 3b and 3c have dual activity of neurotrophy and apoptosis inhibiting activity on oxidation stress damaged PC12 cell.

三、抗神经细胞凋亡实验对目标化合物都进行了体外药理活性试验:以H2O2为凋亡诱导剂损伤PC12细胞构建氧化应激损伤的凋亡细胞模型,用MTT法考察目标化合物对H2O2诱导的神经细胞凋亡的抑制作用。

Accordingly, we suggested that the neurotropism of human enterovirus is not governed by viral IRES. Additionally, we investigated La, PTB, PCBP2, and Unr, the known ITAFs of poliovirus, on their roles in interacting with EV71 IRES.

结果发现虽然不同病毒其IRES活性也有所不同,但是在神经细胞与非神经细胞间却没有差异,表示肠病毒的IRES活性不受神经系统与否所影响,因此肠病毒的神经趋性是由IRES以外的因素所造成。

In the latter case the graft and host tissue mixed togethor. In the grafts there were yellow-green fluorescence-bearing catecholaminergic neurons and TH immunoreactive neurons appearing as fusiform or polyangular shape.

荧光显微镜下可见移植物内有发黄绿色荧光的儿茶酚胺能神经细胞,免疫细胞化学显示移植区内有TH阳性神经细胞,后者为梭形或多角形。

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