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Transgenic expression of IL-1ra and degree of audiogenic seizure of P77PMC rats were observed after infection with pHSV-IL-1ra virus (〓 virus particles) by i. c. v injection and hippocampus injection. Results show: 1. Overexpression of IL-1ra by pHSV-IL-1ra significantly inhibited seizure attacks of P77PMC rat.

实验结果提示IL-1β可导致神经细胞NMDAR mRNA表达及受体活性增加,从而使其兴奋性增高;脑中内源性IL-1系统的异常很可能是形成P77PMC遗传癫痫易感大鼠惊厥易感性的重要因素之一;我们首次构建并鉴定了pHSV-IL-lra重组质粒,并成功地进行了脑内基因转移,使P77PMC大鼠的惊厥程度明显降低。

BACKGROUND: As a kind of unwounded biomagnetism technique, magnetoencephalography relfects immediate information of cerebral function by using magnetic source imaging through recording changes of magnetic field of neurocytes under different functional status.

背景:脑磁图作为一种无创性生物磁学技术,通过记录神经细胞在不同功能状态下产生的磁场变化,以磁源成像反映脑功能的即时信息。

Results:Taurine induced a rapid, dose-depe ndent increase in cytosolic calcium levels in suspension of neuronal cells,with the extracellular physiological Ca2+concentration.Taurine at the dose of 0.4 mmol/L exhi-bited its highest increase in cytosolic calcium(the increa se per centage of Ca2+was 12.20%±1.24%).

结果: 牛磺酸主要通过刺激细胞内钙库释放,在一定剂量范围内(0.02~6.4 mmol/L)使神经细胞[Ca2+]i轻微升高,在0.4 mmol/L时的升钙作用最大(升钙百分率为12 。20%±1.24%)。

Results:Taurine induced a rapid, dose-depe ndent increase in cytosolic calcium levels in suspension of neuronal cells,with the extracellular physiological Ca2+concentration.Taurine at the dose of 0.4 mmol/L exhi-bited its highest increase in cytosolic calcium(the increa se per centage of Ca2+was 12.20%±1.24%).

结果: 牛磺酸主要通过刺激细胞很痛内钙库释放,在一定剂量范围内(0.02~6.4 mmol/L)使原则神经细胞很痛[Ca2+]i轻微升高,在0.4 mmol/L时的升钙作用最大(升钙百分率为12 。20%±1.24%)。

Methods By establishing the apoptosis model of primary culture of hippocampal neurons induced by hyperthermia, the dynamic change of concentration Ca(superscript 2+)in hippocampal neurons and the influence to Bcl-2 expression were observed after using chelerythrine chloride which was the special inhibitor of PKC.

通过建立体外高温诱导海马神经细胞原代培养的凋亡模型,应用PKC特异性抑制剂氯化百屈菜红碱,观察海马神经元胞内Ca(上标 2+)浓度的动态变化以及对B淋巴细胞瘤基因2蛋白(Bcl-2)表达的影响。

This study is to explore the ability of several chitosan related materials to promote the growth of nerve cells.

研究几种与壳聚糖相关的材料对神经细胞生长的促进作用。

Each of these symptoms can be traced back to excessive stimulation of cholinergic neurons.

这些症状归因于大量的胆碱能神经细胞的刺激。

This paper reviews the pathways of ES cells in vitro being committed and differentiated to hematopoietic cells, cardiomyocytes, neural cells, adipocytes, pancreatic islets, endothelial cells, epithelia, osteoblasts, chondroblast and melanocytes.

文章综述了体外定向诱导ES细胞分化为造血细胞、心肌细胞、神经细胞、脂肪细胞、胰岛细胞、内皮细胞、上皮细胞、成骨细胞、软骨细胞和黑素细胞等的途径和方法。

The Drosophila peripheral nervous system comprises three types of sensory elements: external sense organs, chordotonal organs, and multiple dendritic neurons.

果蝇的周边神经系统包含三类感觉器官:外在感觉器官、弦音感觉器官和多树突神经细胞

By studying the level of firing of individual neurons in the brain's posterior cingulate cortex, the scientists could predict whether the monkey would take the chance to explore new options.

通过研究猴子大脑后扣带皮层中独立神经细胞的活跃程度,科学家们可以预测猴子是否会冒险去探索新的选择。

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