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In the middle of 90's, it has been found that hydrogen sulfide (H2S) is one of the metabolite of aminothiopropionic acid, which might regulate the function of nervous system, especially hippocamp, and might regulation the tension of digestive tube and vascular, which has the similar biological function with NO and CO. Recently, major concern has emerged that H2S might be a novel endogenous agent during the patho-physiological reactions during endotoxic shock. Until now, the role of H2S playing in endotoxic shock is still quite confusing.

九十年代中叶,人们发现在体内半胱氨酸代谢过程中生成小分子气体硫化氢(hydrogen sulfide,H2S),对神经系统特别是海马功能具有调节作用,且可以调节消化道和血管平滑肌张力,其生物学作用类似NO和CO.H2S作为内毒素休克时一系列病理生理反应中的一种新的内源性介质,已开始受到人们的重视。

Improve the sleep:the far-in frared ray of the cotton can accelerate human body's micro-blood's circulation and activate histocyte,thus effectively regulating nerve system and bettering sleep quality

改善睡眠:彩棉中的远红外线作用于人体,能增加人权的微循环血流,激活组织细胞,使人体产生温热效应,有效地调节神经系统,疏通经络,改善睡眠质量。

The clinical symptoms, weight and histopathologic changes of the central nervous system were observed.

通过对小鼠体重,症状及中枢神经系统病理改变的观察,评估EAE模型的建立情况。

BACKGROUND: Some drugs used for sedation and anesthesia produce histopathologic central nervous system changes in juvenile animal models.

背景:一些镇静和麻醉药物的使用在幼小物模型产生了病理性中枢神经系统改变。

The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system, such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

本发明的化合物还可用于预防和治疗TRX-介导的疾病,例如自身免疫性、变应性和炎性疾病,并且用于预防和/或治疗中枢神经系统疾病,例如神经变性性疾病。本发明还提供了包含所述异羟肟酸衍生物的药物组合物以及这些药物组合物的易于依从并且在体内产生治疗有效量的所述异羟肟酸衍生物的安全剂量方案。

A drug,C14H19NO2,chemically related to amphetamine,that acts as a mild stimulant of the central nervous system and is used especially in the form of its hydrochloride for the treatment of narcolepsy in adults and hyperkinetic disorders in children.

哌醋甲酯一种药,C14H19NO2,与苯丙胺有化学上的联系,用作中枢神经系统弱兴奋剂,尤其以其氢氯化物形式来治疗成人的发作性睡眠病和儿童的运动功能亢进失调

The Central nervous system has long been regarded as "immunologically privileged site" for the blood-brain ...

中枢神经系统由于存在血脑屏障和脑实质内缺乏淋巴细胞而被认为是&免疫豁免区&。

Methods The neurological soft signs in 47 defective schizophrenia and 128 indefective schizophrenia were tested and all the patients were evaluated by SANS,SAPS,BIRS and SSSI.

将175例精神分裂症病人采用Carpenter提出的关于缺陷综合征的诊断标准划分为缺陷型(47例)、非缺陷型(128例),对其神经系统软体征进行评定,同时应用阴性症状评定量表、阳性症状评定量表、简明智能评定量表、住院精神病人社会功能评定量表分别进行评定并进行相关分析。

XU Minxiu,LIU Yuhou.Linyi Mental Health Center,Shandong 276005,ChinaObjective To explore the related factors of neurological soft signs in the defective schizophrenia.Methods The neurological soft signs in 47 defective schizophrenia and 128 indefective schizophrenia were tested and all the patients were evaluated by SANS,SAPS,BIRS and SSSI.

将175例精神分裂症病人采用Carpenter提出的关于缺陷综合征的诊断标准划缺陷型(47例)、非缺陷型(128例),对其神经系统软体征进行评定,同时应用阴性症状评定量表、阳性症状评定量表、简明智能评定量表、住院精神病人社会功能评定量表分别进行评定并进行相关分析。

XU Minxiu,LIU Yuhou.Linyi Mental Health Center,Shandong 276005,ChinaObjective To explore the related factors of neurological soft signs in the defective schizophrenia.Methods The neurological soft signs in 47 defective schizophrenia and 128 indefective schizophrenia were tested and all the patients were evaluated by SANS,SAPS,BIRS and SSSI.

将175例精神分裂症病人采用Carpenter提出的关于缺陷综合征的诊断标准划分为缺陷型(47例)、非缺陷型(128例),对其神经系统软体征进行评定,同时应用阴性症状评定量表、阳性症状评定量表、简明智能评定量表、住院精神病人社会功能评定量表分别进行评定并进行相关分析。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

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