神经管

The top of neural tube forms basic encenphalic shape,namely endbrain, interbrain, midbrain and afterbrain. The abnormal closure of neural tube will result in neural tube detects. Encephalocoele is a common congenital malformation whose mechanism was no known. NO participates in the physiologic process of brain.

胚胎脑发育的早期阶段主要是神经板隆起、弯曲、闭合形成神经管，神经管的头部从前向后依次发育形成脑的基本组织形态，即端脑、间脑、中脑、后脑，在神经管闭合过程中出现异常就会导致NTD。

The raw data was processed by using axial, coronal and double oblique multi-planar reformation; Images obtained were graded in terms of quality with a 5-point scale(5=excellent, 4=good, 3=fair, 2=poor, and 1=nondiagnostic). In grading image quality at axial MPR, The radiologic specialists focused on the subarcuate fossa, tendon of tensor tympani, facial recess, vestibular aqueduct and pyramidal eminence, In grading image quality at coronal MPR, attention was given to the scute, crista transversa, fenestra cochleae, lateral malleal ligament and snake eyes signature of cranial nerve, In the grading of the image quality at double oblique MPR, the radiologic specialists concentrated on the malleus, incus, stirrup bone, upper bony semicircular and aquaeductus fallopii, and then to implement statistical analysis. In order to choose the minimum tube current values and the maximum pitch that can satisfy the diagnosis request, image quality of axial, coronal and double oblique reformation images was compared with different tube current groups. 15 ears of volunteers were used to test the validity with the scanning parameter. Subsequently noise, MTF and dose length product were measured by phantoms in different tube current and pitch, the parameters obtained were compared and taken into statistics analysis.

扫描模式使用临床常用的颞骨螺旋扫描方式：管电压120 kV，准直宽度20×0.6 mm，视野200 mm，重建矩阵512×512，旋转时间1 s/r，重建层厚0.6 mm，重建间隔0.3 mm，分别改变管电流(380、300、200、160、120和80 mA)和螺距(0.8、1.0和1.2)进行扫描和重建，然后对颞骨进行横断面、冠状面和双斜面多平面重组，于重组后的横断层面图像上选取弓形下窝、鼓膜张肌腱、面神经隐窝、前庭导水管和锥隆起5个解剖结构，冠状面重组图像上选取盾板、横嵴、蜗窗、面神经的蛇眼征和锤骨外侧韧带5个解剖结构，双斜面重组图像上选取锤骨、砧骨、镫骨、上骨半规管和面神经管5个解剖结构，在双盲的情况下由放射学专家分别对各管电流和螺距下扫描的重组图像进行评分，随后进行统计学处理，从中筛选出满足诊断要求的最低管电流值和最大的螺距，分别采用患者25例(15耳)用该管电流值和螺距验证其可行性；然后利用模体分别测试各管电流和螺距下的图像的空间分辨率、噪声及其剂量长度积，并对测试所得参数数值进行比较和统计学处理。

The indirect signs were hematocele sphenoid, ethmoid hematoma, optic nerve thickening, teardrop sign. In the 19 cases(22eyes) of optic canal fracture, single-walled fractures 17 eyes(77.3%), multi-walled fractures 5 eyes(22.7%).

视神经管HRCT检查可清楚的显示视神经管骨折的部位及分型，进行准矢状位重建可提高骨折的检出率，可为临床诊断及选择治疗方案提供可靠的影像学依据。

Neurulation is an important stage in the embryo development of vertebrate, during which the ectoderm thickens into epidermal neural plate and then forms neural folds and neural tube.

脊椎动物胚胎发育过程中，神经胚期是一个重要的发育时期。这个阶段胚胎外胚层增厚形成上皮型神经板，神经板两侧隆起形成神经褶，随后神经褶两侧向背中线合拢并愈合成神经管。

MethodsNeural tubes isolated from the region between midotic placode and third somite of mouse embryo at ED 8.5d were cultured in DMEM/F12 serum-free medium containing basic fibroblast growth factor and epidermal growth factor. The cell cycle of CNCCs was analyzed with flow cytometry, the proliferation capability was determined by MTT method, AP-2α expression was detected by immunocytochemistry as a biological marker of cardiac neural crest cells. The features of migration, multi-directional differentiation were observed as well.

材料与方法成年2月龄C57／BL6小鼠交配，取ED8.5d小鼠胚胎枕中部至第3体节神经管，应用包含碱性纤维生长因子和表皮细胞生长因子的无血清培养基培养，利用MTT法检测细胞增殖能力，利用流式细胞仪检测细胞周期，采用转录激活因子2α(AP-2α，Activator protein-2α)作为其生物学标记物，观察其增殖状况、细胞周期、迁移、分化等生物学特性。

Spina bifida is when neural tube does not develop properly and this results in an incorrectly developed spine.

脊柱裂是神经管时，并不适当发展和结果，这在一个不正确的发展脊柱。

ConclusionThe bone destruction of FNC caused by cholesteatomtaous tympanitis can be demonstrated clearly by CPR,which is an excellent method to provide the morphological observation of the FNC of each patient and decrease facial nerve injury.

面神经管CPR能准确显示胆脂瘤型中耳炎继发的面神经管骨质破坏，可为每位患者术前提供可靠的形态学研究，有效避免术中面神经损伤。

Collecting a total of 102 cases(107eyes) of pations with traumatic optic neuropathy that underwent edoscopic optic nerve decompression surgery during December 1999 - April 2008 line,retrospective analysis of CT performance for the optic canal and paranasal sinuses,and Comparison of them with surgical results.102 cases of patients performed routine and coronal axial sinus CT scans,the optic canal zone wi th thin target scan,line of nasal tip and the anterior clinoid process connection as baseline for axis scan,and the vertical line of "bed nasal line" as baseline for coronal scan.

方法收集1999年12月-2008年4月间在青医附院耳鼻喉科行鼻内镜下视神经减压手术的外伤性视神经病患者的病例，共102例(107眼)，回顾分析其鼻窦及视神经管CT表现，并查看手术记录描述，将CT结果与术中所见情况进行对比分析。102例患者术前常规行轴位及冠状位鼻窦CT扫描，视神经管区行薄层靶扫描，以骨性鼻尖与前床突的连线为轴位扫描基线，以&床鼻线&的垂直线为冠状位扫描基线。

The results show that the single-layered neural tube fails to form and the neural crest cells remain at the lateral regions in the explants with NTDs. However, the patterning of the neural tube is not affected as indicated by the normal expression of the preneural genes.

结果显示神经管闭合缺陷的移植体不能形成单层化的神经管，并且神经晴细胞滞留在侧面区域不能向背侧中线迁移，而对神经前体标记基因的检测显示神经管的背腹图式形成并未受到影响。

Methods The sphenoidal sinus was opened and then fracture of the optic canal was made by transnasal endoscopy with a hammer in 20 domestic cats, and optic nerve decompression was made 8 hours later.

鼻内镜下开放20只家猫的蝶窦，于蝶窦外侧壁锤击视神经管，造成视神经管骨折，8h后鼻内镜下行视神经管减压。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。