神经突

The acute reaction of neurons against axon repellents is the collapse of growth cones, while the chronical reaction is the change of axon growth direction when they are cocultured with repellents secreting cells.

神经轴突对神经生长排斥因子的急性反应是生长椎的萎缩；将神经元与分泌排斥因子的细胞共同培养时引起的慢性反应是轴突生长方向的改变网。

Between any neurons, between the axon of one neuron and the dendrite of another, there's a tiny gap.

在任何神经之间，在轴突和一个神经以及另一个树突之间，有一个微小的分歧。

Two types of pituicytes and three types of neurosecretory fibers (A1, A2 and B) have been recognized in neurohypophysis. The neurosecretory terminals contain different diameter and shape of secretory granules.

神经垂体组织中存在2种类型的脑垂体细胞，并可以区分A1、A2和B 3种类型的神经分泌纤维，其终端轴突中具有不同直径和形态的分泌颗粒；B型纤维轴突中含有许多透明小囊泡。

It was found greater expression of NRP2-1 and NRP2-2 in pituitary, ovary, uterus and oviduct of ruttish Erhualian than corresponding tissues of ruttish Duroc, which suggested enhancing expression of NRP2 was favorable to increasing litter size. But the difference of NRP2 expression was not significant between two breeds, which suggested the key phase that NRP2 affected litter size was not oestrum probably, or NRP2 could enlarge cell signals and finally affect litter size ascribe that it was the receptor of nerve axon guidance factors.

NRP2-1和NRP2-2在发情期二花脸卵巢、子宫、输卵管中的表达量均大于杜洛克相应组织的表达量，推测NRP2表达水平高可能有利于提高产仔数，但两品种间表达差异不明显，推测NRP2影响产仔数的关键阶段可能不是猪的发情期；另外，NRP2 是神经轴突介导因子的受体，这些神经轴突转导的信号往往有级联放大的功能，虽然NRP2-1和NRP2-2在二花脸和杜洛克卵巢、子宫、输卵管中的表达差异不大，但二花脸有可能通过神经系统转导信号的级联放大最终引起一些效应激素或蛋白的急剧增加，从而提高排卵率或产仔数。

The release is triggered by Ca〓 and completed by the fusion of neurotransmitter containing synaptic vesicles with the presynaptic membrane.

神经递质的释放是由钙引发的，由含神经递质的突触囊泡与突触前膜融合完成的。

Results:(1)NSCs form typical neurospheres under adequate concentration in vitro, which are immunoreactive to Vimentin. Typically and terminally differentiated mature neural cells could not be found without the stimulus of mitogen or only under NSCs self-regulation and self-induction;(2)NSCs derived from hippocampus maintain the character of stem cells much longer with better biological behavior; NSCs passed to the 2-3 passage are the best to graft since they have not differentiated;(3)NSCs cultured in vitro could self-regulate and differentiate into neurospheres and progenitors positively immunoreactive to specific antibodies representing neurons, astrocytes, oligodendrocytes and Schwann cells;(4)There are widespread synaptic contacts between various kinds of descendent clones and cells;(5)Neurospheres could be formed without the stimulus of mitogen when NSCs and OECs are cocultured. Many neurospheres and cells immunoreactive to Vimentin, GFAP, MAP2, 02, p75NGFR, GFAP, S-100, Synaptosis, Vimentin, Tau (Tau is only positive in cocultureof HNSCs+HOECs) could be found;(6)The supernatant fluid triturated from adult rat spinal cord stimulates NSCs to differentiate into neurons, but do not terminally differentiate;(7)Fibroblasts and O4 oligodendrocytes are not supported to grow under this culture medium.Part II: Isolation, culture and identification of rat and human olfactory ensheathing cellsOlfactory ensheathing cells/glials are the most powerful cells to enable the regeneration of axons in the central nervous system.

结果表明：①在适宜的浓度体外培养条件下，NSCs能形成典型的神经干细胞克隆球，Vimentin免疫荧光染色阳性，单靠丝裂原刺激或NSCs自我调节和分化诱导，不会产生典型的终末分化的成熟神经细胞；②海马源性的NSCs维持干细胞特性的时间更长，生物学特性更优；③传至第2～3代的NSCs尚未分化时移植最佳；④体外培养的NSCs能自我调控分化为神经元、星形胶质细胞、O2少突胶质细胞、雪旺氏细胞染色阳性克隆球和前体细胞；⑤各种子代克隆球和细胞存在广泛的突触联系；⑥NSCs与OECs联合培养时，不需丝裂原刺激即能形成克隆球，获得大量Vimentin、GFAP、MAP2、O2、p75NGFR、GFAP、S-100、Synaptosis、Vimentin、Tau(Tau只有人HNSCs+HOECs联合培养时出现阳染)染色阳性的克隆球和细胞；⑦脊髓研磨后的上清液刺激神经干细胞向神经元方向分化，但并不出现终末分化；⑧本研究培养条件不利于成纤维细胞、O4生长。

BACKGROUND: Synaptophysin P38 is widely distributed in nerve ending of a body, which is closely associated with nerve growth, recovery, regeneration and synapsis remodeling.

背景：突触素P38广泛存在于机体所有神经终末，与神经生长、修复、再生和突触重塑密切相关。

Methods:Three-dimensional(3D) CT imaging reconstruction was performed in 200case of cervical spine without radicular symptom and injury.C_3-C_7 vertebral body horizontal diameter, sagittal diameter,high.vertebral gap.pedicle vertical diameter and horizontal diameter,coronary high,base long of vertebral uncus,space between vertebral uncus point.highness and width of intervertebral foramenand,transverse foramen,The CT data was transferred to a computer workstation,grouping with age and sex,statistical analysis.

材料与方法：选取200名不同年龄段无外伤、无神经症状和体征的受检者，进行多排螺旋CT薄层扫描，在计算机工作站上对获得图像进行多平面重建，获得相应截面图后，测量各相关指标，包括第3至第7颈椎(C_3-C_7)椎体横径、矢状径及高，椎体间隙，椎弓根的高与宽，冠状位钩突高度、钩突基底宽度、基底长、两侧钩突尖间距及基底长径角度，椎间孔高和宽，横突孔长和宽。按性别、年龄分组进行统计学分析。

The in vitro effects of Gln49-PLA_2 were examined using the chick biventer cervicis nerve muscle preparation. Gln49-PLA_2 caused a dosedependent blockade of neuromuscular transmission. The time required to cause 50% blockade was about 150 min at the highest concentration 100μg/ml. This inhibition appeared to be presynaptic in origin as evidenced by the lack of effect of toxin on responses to exogenous acetylcholine in the non-stimulated BCp.

Gln49-PLA_2能够剂量依赖性地抑制颈二腹肌神经信号正常传导并影响肌肉收缩，在100μg/ml剂量下，肌肉收缩幅度在150分钟后达到50%的抑制率；同时，随着Gln49-PLA_2浓度的降低，肌肉收缩幅度的抑制效率也逐渐降低；实验证明Gln49-PLA_2对突触后膜乙酰胆碱受体敏感性无影响，对神经肌肉信号传导收缩的抑制作用位点在突触前膜。

The quantity of the synapses in neuropil of the model group decreasedsignificantly(P＜0.01), and the typical synapse structure was destroyed; the quantity of thesynapses in neuropil of Musk with Borneol group was significantly higher than that of themodel group (P＜0.05) and the synapse form was almost normal.

模型组较假手术组神经毡内突触明显减少(P＜0.01)，典型的突触结构遭到破坏；麝香配伍冰片组突触数量较模型组明显增多(P＜0.05)，突触形态大部分接近正常。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。