神经硬化

BACKGROUND: After amyotrophic lateral sclerosis, motor neurons have changes in neural degeneration, but the precise mechanism is not clear.

摘要背景：肌萎缩侧索硬化后运动神经元存在神经变性改变，但其确切机制不明，内源性神经干细胞被认为是未来能有效解决此病的治疗方法之一。

"Our observations, combined with those of others, suggest that widespread axonal dysfunction is associated with fatigue in MS," write Maria Carmela Tartaglia, BSc, MD, from Montreal Neurological Institute and Hospital in Quebec, Canada, and colleagues."It may be hypothesized that diffuse white matter disease translates into an increase in the central nervous system effort required by a patient with MS to perform the same activity as compared with a disease-free subject, with resultant fatigue."

来自加拿大魁北克医院及蒙特娄神经学学会的Maria Carmela Tartaglia博士和其同僚表示，他们的观察结合了其他人的之后建议，多发性硬化症患者的疲劳症状和广泛性轴突功能障碍和有密切关联，其可被假设为为当多发性硬化症患者在和其他正常人做同一活动时，其弥漫性白质疾病导致中枢神经做功增加，而产生较疲劳的结果。

At the same time, PDI can act as molecular chaperone that help the denatured proteins refold and inhibit the aggregation of the denatured proteins.

在神经变性疾病如帕金森症、阿尔兹海默症、肌萎缩侧索硬化症、多聚谷氨酰胺疾病中，PDI可通过抑制错误折叠蛋白的聚集以及遍在蛋白化，起到神经保护作用。

Nodes of Ranvier; saltatory conduction; Schwann cells; oligodendrocytes; myelin basic protein; demyelination; remyelination; myelinopathy; myelinogenesis; myelin-associated protein; myelin sheaths; demyelinating neuropathy; myelin proteolytic protein; chronic inflammatory demyelinating polyradiculoneuropathy; multiple sclerosis; MS

郎飞氏结；跳跃传导；施旺细胞；少突神经胶质细胞；髓鞘碱性蛋白脱髓鞘；髓鞘再生；髓鞘质病；髓鞘形成；髓磷脂-关联的蛋白质；髓鞘；脱髓鞘神经病；髓磷脂溶解蛋白的蛋白质；慢性炎症性脱髓鞘多神经根神经病；多发性脑硬化；MS

The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis.

神经磷脂饮食对血浆神经磷脂代谢和动脉粥样硬化的效应

The aim of our study was to analyse the interdependence of inflammation, neurodegeneration and disease progression in various multiple sclerosis stages in relation to lesional activity and clinical course, with a particular focus on progressive multiple sclerosis.

我们的研究目的是，在与病灶活动性及临床病程相关的多发性硬化症的不同阶段，分析炎症、神经退行性病变和疾病发展间相互依赖的关系，尤其侧重于对多发性硬化症进展期的研究。

Matsuyama et al used calcium phosphate cement, which polymerizes at lower temperatures.37,38 Results were good in terms of pain relief (8.6 preoperatively and 2 postoperatively on the visual analog scale), neurologic recovery and kyphosis restoration (vertebral height was restored to 68%, compared to 41% preoperatively).37,38 This combination of maximal/minimal surgical treatment has value especially in neurologically compromised patients with indication for surgery, who cannot tolerate long procedures and large blood loss due to medical comorbidities.

Matsuyama等人使用磷酸钙骨水泥，其硬化反应温度较低[37，38]，结果表明疼痛缓解良好（视觉模拟评分从术前的8.6分减至术后的2分），神经功能恢复和后凸畸形矫正良好（椎体高度从术前的41％恢复至术后的68 ％）[37，38]，这个&最大/最小&的手术组合治疗方法，尤其适合伴有神经症状而不能耐受长时间的手术和大量失血的患者。

Fatigue is a widespread symptom in numerous neuroimmunological diseases like multiple sclerosis, myasthenia gravis, morbus Behcet, neurosarcoidosis, neuroborreliosis or immune vasculitis.

疲劳是为数众多的神经免疫疾病如多发性硬化、重症肌无力、贝切特病、神经肉瘤病、神经包柔螺旋体病或免疫性血管炎中的常见症状。

Fatigue is a widespread symptom in numerous neuroimmunological diseases like multiple sclerosis, myasthenia grais, morbus Behcet, neurosarcoidosis, neuroborreliosis or immune asculitis.

疲劳是为数众多的神经免疫疾病如多发性硬化、重症肌无力、贝切特病、神经肉瘤病、神经包柔螺旋体病或免疫性血管炎中的常见症状。

A three layers BP neural network model for the corrosion weight-loss of the gas turbine wheel part in heavy oil impurity environments was set up by using Nimonic 80A corrosion weight-loss data in the different heavy oil impurity environments, and the influence law of the gas turbine wheel part corrosion weight-loss was predicted.

利用三层BP神经网络，根据已有的镍基合金（Nimonic 80A合金镍基沉淀硬化）在不同重油杂质环境参数下的腐蚀速度数据，建立了燃气轮机的涡轮部件在重油杂质环境中腐蚀失重的人工神经网络模型，并进一步预测了腐蚀失重。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。