神经瘤的

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Pleomorphic adenoma is the most common gland tumor of parotid origin, accounting for 60 to 70%. This kind of tumor usually presents as a slow-growing painless mass anteroinferior to the ear. The diagnosis is based on physical examination, image studying and even fine needle aspiration biopsy. The optimal method of treatment of such tumors is local excision or paroidectomy in which the entire capsule is totally dissected off but the facial nerve is spared. Diagnosis and treatment planning are focused on preventing tumor recurrence and consequent malignant transformation.

腮腺之多形性腺瘤乃是唾液腺最常见的肿瘤，约占所有唾液腺良性肿瘤的百分之六十至七十，这类的肿瘤在临床上的表现常是耳下缓慢增生的无痛性肿块，临床上诊断的依据必须配合临床检查、电脑断层扫描、磁振造影及细针抽取切片的病理检查方可得知，其治疗方式主要是对肿瘤进行局部切除手术或腮腺的切除手术，手术中颜面神经需小心保留，但须将肿瘤的外膜部分切除乾净，诊断及治疗计画著重在预防肿瘤复发及肿瘤产生恶性转变。

Results:Most of the intracranial chordoma（16 cases in our group,88 9%）were located in the middle area of the skull base such as clivus and/or sellar region and always invaded extensively the nerves and major in tracranial vessels of skull base.All tumors were hypointense on T1- weighted imaging and heterogeneous hyperintense on T2- weighted imaging,On Gd- DTPA contrast- enhanced T1- weighted imaging 8 chordomas enhanced more markedly,but steady heterogeneous.

结果：颅内脊索瘤大部分（本组16例，占889%）发生于颅底中线处的斜坡和/或鞍区，并广泛侵犯颅底的神经和大血管等重要结构；在T1加权像上肿瘤主要表现为低信号，T2加权像上表现为不均匀高信号，Gd-DTPA静脉注射增强后（8例）均出现较明显的不均匀强化。

We found that malignant human glioma cells constitutively expressed matrix metalloproteinase-2 (MMP-2), and the MMP-2 activities were correlated well with their malignancies.

我们发现恶性人类神经胶质瘤细胞会持续的表现matrix metalloproteninases-2 (MMP-2)，而且MMP-2的活性和肿瘤细胞的恶性度有密切的关系。

A 5.0 cm, well-circumscribed, firm, multinodular ganglioneuroma that arose in the adrenal.

在肾上腺出现一个5.0cm大小的、比较局限的、质硬的、多结节的神经节瘤。

When MR imaging shows thickening and enhancement of the pituitary stalk and associated leptomeningeal disease as in this case, sarcoidosis is a very strong possibility, along with meningitis, particularly fungal.

结节病为一种不明原因的炎性病变，可以影像多个系统，包括中枢神经系统，女性多见，大于10：1，黑人比白人更多见，15%病人累及中枢神经系统，5%有神经症状，脑神经功能障碍和尿崩症是最常见的神经系统结节病的临床表现，MR改变包括脑膜增厚及强化，孤立性肿块或多发性小，散在的脑膜或实质病变，此例病例中MR图像出现增厚强化的垂体蒂伴有软脑膜病变，强烈提示结节病，伴随脑膜炎尤其是真菌性，通常T2表现为低信号，虽然这些也能够在霉菌病/淋巴瘤/脑膜瘤中看到。

2B8a was weakly reactive to neutrophils (23.72%) and negative for T cells, NK, DC, RBC and Plt. The antibody reacted to all 3 marrow CD34+ cells with an average positive rate of 39.33% while it was negative for G-CSF-mobilized CD34+ peripheral blood stem/progenitor cells (PBSC, 1.25%). Cell line analysis showed that the antibody notably reacted to three out of 4 cell lines (Raji, SMS-SB, Nalm-6 and Nall-1) with the positive rates of 98.78%, 98.61%, 94.93% respectively and weakly to one of them with 5.68% in B lineage cell lines and monoblastic cell line (U937, 67.78%) while it was only weakly positive or negative for other myeloid leukemia cell lines including Meg01 (33.40%), HL-60 (29.70%),K562 (28.19%), KG1a (16.23 %) and HEL92.1.7 (8.02%). Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.

结果表明： 2B8a抗原在外周血B细胞上表达（3/3例，平均阳性细胞数为26.29 ％），而在T淋巴细胞和NK细胞上不表达（0/3例）；在粒细胞和单核细胞上阳性表达均为2/3例，平均阳性细胞数分别是23.72 ％和59.84 ％；在DC细胞、红细胞和血小板上均不表达（0/3例）。2B8a抗原在骨髓CD34＋细胞上的阳性表达是3/3例，平均阳性细胞数39.33 ％，而在G-CSF动员的外周血CD34+细胞上的阳性表达仅1/3例，平均阳性细胞数为1.25 ％。2B8a抗原在B系细胞系Raji、SMS-SB、Nalm-6和Nall-1上的平均阳性细胞数分别为98.78 ％、98.61 ％、94.93 ％和5.68 ％；在T系细胞系Molt-3上的平均阳性细胞数为31.40 ％，而在Molt-4、JM和CCRF-CEM 细胞上不表达；在髓系细胞系U937、Meg-01、HL-60、K562、KG1a和HEL92.1.7上的平均阳性细胞数分别为67.78 ％、33.40 ％、29.70 ％、28.19 ％、16.23 ％和8.02 ％；在神经母细胞瘤细胞系SK-N-SH、KCNR、BE、LAN-1和SK-N-AS细胞以及结肠癌细胞系HR8348细胞上均不表达，而在羊膜细胞系FL细胞上呈一定的阳性表达，平均阳性细胞数为45.03％。

Cell line analysis showed that the antibody notably reacted to three out of 4 cell lines (Raji, SMS-SB, Nalm-6 and Nall-1) with the positive rates of 98.78%, 98.61%, 94.93% respectively and weakly to one of them with 5.68% in B lineage cell lines and monoblastic cell line (U937, 67.78%) while it was only weakly positive or negative for other myeloid leukemia cell lines including Meg01 (33.40%), HL-60 (29.70%),K562 (28.19%), KG1a (16.23 %) and HEL92.1.7 (8.02%). Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.

结果表明： 2B8a抗原在外周血B细胞上表达（3/3例，平均阳性细胞数为26.29 ％），而在T淋巴细胞和NK细胞上不表达（0/3例）；在粒细胞和单核细胞上阳性表达均为2/3例，平均阳性细胞数分别是23.72 ％和59.84 ％；在DC细胞、红细胞和血小板上均不表达（0/3例）。2B8a抗原在骨髓CD34＋细胞上的阳性表达是3/3例，平均阳性细胞数39.33 ％，而在G-CSF动员的外周血CD34 细胞上的阳性表达仅1/3例，平均阳性细胞数为1.25 ％。2B8a抗原在B系细胞系Raji、SMS-SB、Nalm-6和Nall-1上的平均阳性细胞数分别为98.78 ％、98.61 ％、94.93 ％和5.68 ％；在T系细胞系Molt-3上的平均阳性细胞数为31.40 ％，而在Molt-4、JM和CCRF-CEM 细胞上不表达；在髓系细胞系U937、Meg-01、HL-60、K562、KG1a和HEL92.1.7上的平均阳性细胞数分别为67.78 ％、33.40 ％、29.70 ％、28.19 ％、16.23 ％和8.02 ％；在神经母细胞瘤细胞系SK-N-SH、KCNR、BE、LAN-1和SK-N-AS细胞以及结肠癌细胞系HR8348细胞上均不表达，而在羊膜细胞系FL细胞上呈一定的阳性表达，平均阳性细胞数为45.03％。

This research has proved that an artificial neural network is capable to differentiate the reactional enhancement of malignant intracranial gliomas in postoperative MR images and the enhancement caused by tumor residual. As a innovative differentiation approach, it requires further studies and researches to determine its applicability in practice, including the increase of training samples, image description standardization, effects to doctoral diagnosis, as well as parameter optimization. With improvements in these elements, the performance of the network will be optimized.

本研究成功地证明了人工神经网络能够鉴别颅内恶性胶质瘤术后磁共振图像的反应性强化与肿瘤残存所致的强化，为解决二者的鉴别这一复杂问题提供了一个新的方法，但是本研究只是初步的应用探讨，能否在实际中应用，还有待于进一步的研究，如训练样本的增加、图像描述的规范化、对医师诊断影响程度、参数的优化等，网络的性能会不断完善和提高。

There were all kinds of tissue cells in the teratomas acquired from in-vitro differentiation, such as, neuro epithelium, skeletal muscle, respiratory epithelium. This further proved the isolated mouse ES cells could differentiate into three germ layers of tissue types.

体内分化实验所获得的畸胎瘤中存在各种组织细胞，如一些神经上皮样组织；横纹肌；呼吸上皮样组织等，这进一步证明所分离获得的小鼠ES细胞具有三个胚层的分化能力。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐