神经瘤的

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Results MRI findings of central neurocytoma are specific in 5 cases. The ganglioglioma was found in the tempora and occipital lobe in 7 cases,in the brainstem in 1 case, cystic-solid tumor was observed in 5 cases with extramural nodule in 3 cases, obviously thickened gyri were revealed in 1 cases and central necrosis in 2 cases.The 3 cases of Lhermitte-Duclos disease include the specific molecular layer imaging features.

结果 5例中枢神经细胞瘤有一定的MRI特征，3例诊断正确。8例神经节细胞胶质瘤中，7例位于或主要位于颞、枕叶，1例位于桥脑和延髓，表现为囊实性者5例，实性部分位于囊外的有3例，呈实性表现为局部脑回增厚者1例，囊变坏死明显者2例。3例小脑发育不良性节细胞瘤有特征性的条纹状或分层状表现。

It has done a lot investigation on the microneurosurgery technique and monodrama operations, performed different kinds of complicated and difficult operations successfully such as resection of cranial basis tumors , cerebrovascular disease, resection of pituitary tumor by nose way , resection of spinal cord tumors, spinal cord congenital malformation .

是国内较早开展显微神经外科手术单位之一。在显微神经外科技术和微创手术方面做过许多研究，成功完成了各种神经外科疑难与复杂手术，如颅底肿瘤的显微手术、脑血管病的微创与介入手术、经鼻蝶入路垂体瘤切除手术、脊髓髓内肿瘤、脊髓先天性畸形的显微手术等。

Degenerative nuclear atypia (akin to that seen in ancient schwannoma and atypical neurofibroma) is relatively common.

退变的不典型瘤细胞（类似于在古老型神经鞘瘤和不典型神经纤维瘤中所见到的一样）相对常见。

Methods:The CT and MPd features of rare adrenal neoplasms verified with operation and pathology were investigated retrospectively in 21 eases. The tumor included adrenal cyst 8 cases, myelolipoma 7 cases, ganglioneuroma 3 cases, neurofibrroma, primary malignant lymphoma and malignant mesothe lioma 1 eases respectively.

对21例经手术和病理证实的肾上腺少见肿瘤的CT、MRI表现进行回顾性分析，包括囊肿8例、髓质脂肪瘤7例、神经节细胞瘤3例、神经纤维瘤、原发恶性淋巴瘤及恶性间皮瘤各1例。

CCSK is a rare type of renal neoplasm in childhood and its diagnosis relies mainly on histopathology and immunohistochemistry. It is important to be familiar with the morphological variants of CCSK to avoid confusion with other similar lesions, such as Wilm's tumor, congenital mesoblastic nephroma, malignant rhabdoid tumor of kidney, primitive neuroectodermal tumor.

CCSK是一种罕见的儿童期恶性肾肿瘤，诊断主要依靠组织病理学和免疫组化，熟悉其形态学变异有利于与其它类似病变如肾母细胞瘤、先天性中胚叶肾瘤、肾恶性横纹肌样瘤、原始神经外胚叶肿瘤等鉴别。

In contrast to plexiform neurofibromas, plexiform schwannoma is only weakly associated with neurofibromatosis type 1 (von Recklinghausen's disease), and has little malignant potential.

相对於丛状神经纤维瘤，丛状神经鞘瘤与第一型予纤维瘤病(neurofibromatosis type 1，von Recklinghausen's disease)的相关很薄弱，而且没有恶性变化的倾向。

Malignant peripheral nerve sheath tumor is an aggressive spindle cell sarcoma that is closely associated with neurofibromas, neurofibromatosis type 1 and from the sites previously irradiated.

恶性周边神经髓鞘瘤是一种恶性纺锤细胞肉瘤，和神经纤维瘤、第一型多发性神经纤维瘤症和以前接受过放射治疗的部位有密切相关。

It provided an optional treatment for patients with small to medium size acoustic neuromas, and an important adjuvant therapy for treating residual and recurrent tumors

无面瘫和面部麻木，听力保留率59I2%结论伽玛刀对听神经瘤有较高的肿瘤控制率，并能保留有用听力，对面神经、三又神经损伤小，是小至中等大小听神经瘤可供选择的治疗方法，及术后残余和复发肿瘤的重要辅助治疗手段。

Based on all images of 2D-DSA and 3D-DSA,we evaluated the aneurysm detective rate,visibilities of both aneurismal neck and its relationship with the parent artery,the dose of contrast media.3.Statistics:With SPSS 11.0 software,measurement data was demonstrated by?

由2名资深神经影像医师采用盲法分别阅片并记录两种方法动脉瘤的检出情况、瘤颈显示情况、瘤体与载瘤动脉的关系及对比剂用量，对其结果进行比较分析。3、统计学处理：采用SPSS 11.0软件，计量资料采用？

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。