神经瘤

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Results Among 85 cases, 46 cases were lipomas, Twenty-seven cases were sebaceous cysts, 19 cases were angeiomas, 8 cases were fibroids, 5 cases were ganglionic cysts, 3 cases were neurilemmomas,1 case was dermal nevus, 1 cases was fattey necrosis, 1 case was adipositis, 1 case was foreign-body granuloma,1 case was calcified epithelioma.

结果 85例中脂肪瘤46例，皮脂腺囊肿27例，血管瘤19例，纤维瘤8例，腱鞘滑液囊肿5例，神经鞘膜瘤3例，皮肤痣、脂肪坏死、脂膜炎、异物肉芽肿、钙化上皮瘤各1例。

Results The etiology of exophthalmos in children includes two aspects:（1）the outside of ocular diseases,mainly including Langerhans cell histiocytosis,chloroma,neuroblastoma etc.（2）ocu-lar diseases,mainly including retioblastoma,rhabdomyosarcoma of the orbit,glioma of optic nerve and angioma of the orbit and so on.

结果 提示小儿突眼病因主要包括两方面：（1）眼外疾患，主要包括有郎格罕组织细胞增生症、绿色瘤、神经母细胞瘤等；（2）眼部疾患，主要包括视网膜母细胞瘤、眶横纹肌肉瘤、视神经胶质瘤、眶内血管瘤等。

Tanycytic ependymoma is a rare subtype of ependymoma. The differential diagnosis with schwannoma and astrocytoma should be considered.

伸长细胞型室管膜瘤是室管膜瘤的一种罕见亚型，病理诊断时尤其应注意与椎管内的神经鞘瘤和星形细胞瘤鉴别。

Results The main CTimages of adrenal neuroblastoma in children were bigger extrarenal tumor ,included :huge and irregular mass(6 cases ),regular mass (2 cases),calcification (87cases),cystic degeneration or necrosis (1cases),bleeding(2cases),crossing of the midline (5cases),wrapping retroperitoneal major vessels (4cases),retroperitoneal enlargement of lymphnode (7 cases),The masses were heterogeneous enhancement.

分析2004年10月～2008年10月经手术病理证实的8例儿童肾上腺神经母细胞瘤的CT表现，如形态，密度及周围结构变化情况，结合临床资料，进行综合评价。结果儿童肾上腺神经母细胞瘤为肾外体积较大肿块，其中不规则肿块6例，规则2例，钙化7例，囊变坏死1例，出血2例，越过中线5例，包绕腹膜后大血管4例，腹膜后淋巴结肿大7例，肾脏向后外侧移位6例。

Microscopically, the tumor in the sigmoid colon showed sheet-like growth of epithelioid cells with abundant clear cytoplasm and round nuclei, which were separated by thin fibrovascular septa.

影像学显示乙状结肠壁肿瘤，其表现不同于神经母细胞瘤。此外，腹股沟和颈部淋巴结有神经母细胞瘤的转移。

Ganglioneuroma is a rare, benign tumor. It arises from neural crest cells, similar to pheochromocytoma, and grows slowly.

神经节神紃瘤是一种罕见的良性肿瘤，它和嗜铬细胞瘤一样，都是由神经脊细胞分化而来。

Results Among 85 cases, 46 cases were lipomas, Twenty-seven cases were sebaceous cysts, 19 cases were angeiomas, 8 cases were fibroids, 5 cases were ganglionic cysts, 3 cases were neurilemmomas,1 case was dermal nevus, 1 cases was fattey necrosis, 1 case was adipositis, 1 case was foreign-body granuloma,1 case was calcified epithelioma.

回顾性分析85例体表良性肿块的超声表现，总结其声像图特征，所有病例均经手术病理证实。结果 85例中脂肪瘤46例，皮脂腺囊肿27例，血管瘤19例，纤维瘤8例，腱鞘滑液囊肿5例，神经鞘膜瘤3例，皮肤痣、脂肪坏死、脂膜炎、异物肉芽肿、钙化上皮瘤各1例。

Qiaobusi accepted endocrine of nerve of pancreas islet cell 2004 tumour excises an operation, and the Heer such as the insulin that tumour can make the body makes excessive cheats nerve endocrine.

2004年乔布斯接受胰岛细胞神经内分泌瘤切除手术，而神经内分泌瘤会使身体制造过量的胰岛素等贺尔蒙。

Results: The findings on CT and MRI were as follows: 57 cases of Oligodendroglioma, 15 cases of Ganglioglioma , 5 cases of Dysembryoplastic neuroepithelial tumor , 3 cases of Pleomorphic xanthoastrocytoma .

结果：少枝胶质瘤47例，间变性少枝胶质瘤10例，节细胞胶质瘤15例，胚胎发育不良性神经上皮瘤5例，多形黄色细胞瘤3例。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐