神经毒素

BACKGROUND: Amnesic shellfish poisoning is caused by consumption of seafood contaminated by marine neurotoxins, mainly domoic acid.

背景：失忆性贝毒属于海洋神经毒素，是一类具有神经兴奋的氨基酸类物质，其主要成分为软骨藻酸。

The four sea anemone neurotoxins are composed of 47 amino acid residues.

四种新的海葵神经毒素均由47个氨基酸组成。

Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines.

帕金森病的细胞和分子机制：神经毒素，致病基因和炎性细胞因子

Nematocyst in venom is protein-containing nerve toxins, some coelenterate stinging cells can not only paralysis, kill small animals, even sting hurt.

刺丝囊中的毒液为含蛋白质的神经毒素，有些腔肠动物的刺细胞不仅能麻痹、杀死小动物，甚至能蛰伤人。

The neurotoxin tetrodotoxin, its toxicity nearly one thousand times higher than potassium cyanide.

河豚毒素为神经毒素，其毒性比氰化钾要高近千倍。

The identification of protein were performed by searching the mass spectrometry data from the NCBInr database using the software of Sequest Bioworks3. 2. The results indicated that over 25 protein components including acid and basis phospholipase A2, nerve growth factor, presynaptic neurotoxin, hemorrhagic factor, thrombin-like enzyme, serine protease, glycogen synthase, metalloproteinase, maturase, L-amino acid oxidase, plasminogen activator, adhesion, cysteine-rich secretory protein, disintegrin, fibronectin-binding protein, fibrinogen clotting inhibitor A chain, vascular apoptosis-inducing protein 1, pyranose 2-oxidase, carbamoyl-phosphate synthase, as well as the homology proteins of snake venom ablomin, ablomin, catrin, mucrofirase, pallabin, salmosin and triflin homologues were identified from the GSSV.

从GSSV中鉴定出超过25种蛋白组分，主要包括：酸性磷脂酶A1、碱性磷脂酶A2、神经生长因子、突触前神经毒素、出血因子、类凝血酶、丝氨酸蛋白酶、糖原合酶、金属蛋白酶、成熟酶、L-氨基酸氧化酶、纤溶酶源激活物、外源凝集素、富含半胱氨酸分泌酶、去整合素、纤连蛋白结合蛋白、纤维蛋白原凝固抑制因子A、血管凋亡诱导蛋白1、氨甲酰基磷酸合成酶、吡喃糖－2-氧化酶以及ablomin， catrin， mucrofirase， pallabin， salmosin和triflin的同源蛋白。

Following this discovery, a variety of neurotoxins were characterized and their amino acids sequences, secondary structure and tertiary structure were also characterized. These toxins are polypeptides of single chain and consist of 46-49 amino acids, cross-linked by three disulfide bridges. The ordered secondary structure has been determined on the basis of NMR studies. The dominant feature is a four-stranded anti-parallel β-sheet, linked with three loop.

随后，又有多种海葵毒素被发现，并做了氨基酸序列测定，以及二级、三级结构的分析，从已报道的海葵神经毒素的一级结构来看，大都是由46-49个氨基酸组成的单链多肽，分子量5kD左右，有6个cys残基，形成3对二硫键，它们的二级结构中不存在α螺旋结构，而是4链反向β折叠，β折叠由3个大小不同的环结构相连。

The makers of the nerve poison include the mambas and the cobras and their venom is called neurotoxic.

产生神经毒液的蛇有一种非洲树眼镜蛇和眼镜蛇，它们的毒液称为神经毒素。

The makers of nerve poison include the mambas and cobras and their venom is called neurotoxic.

产生神经毒液的蛇有一种非洲树眼镜蛇和眼镜蛇，它们的毒液称为神经毒素。

A large snake or serpent .The makers of the nerve poison include the mambas and the cobras and their venom is called neurotoxic.

产生神经毒液的蛇名叫马姆伯斯的非洲大毒蛇和眼睛蛇，它们的毒液称为神经毒素。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。