神经毒素

Hainantoxin-I is an insect blocker of voltage-gated sodium channel isolated from the venom of the Chinese bird spider Ornithoctonus hainana (early named Selenocosmia hainana).

海南捕鸟蛛毒素-I是从海南捕鸟蛛的粗毒中纯化的一种新型神经毒素。

Huwentoxin-Ⅱ is a neurotoxin purified from the venom of the Chinese bird hunting spider Selenocosmia huwena, which contains 37 amino acid residues including 6 cysteine forming three pairs of disulfide.

虎纹捕鸟蛛毒素Ⅱ（huwentoxin-Ⅱ，HWTX-Ⅱ）是从虎纹捕鸟蛛Selenocosmiahuwena毒液中纯化出的新型多肽神经毒素，含有37个氨基酸残基，包括6个半胱氨酸，形成了三对二硫键。

By sequencing randomly-selected clones from the library and usingbioinformatics, 73 novel expressed sequence tags were obtained, in which therewere 24 full-length cDNAs, including cytolysin gene, neurotoxin genes, and greenfluorescence gene. Functional study on these novel genes is an ongoing task in ourlaboratory.

对文库克隆进行序列测定和生物信息学分析，已经获得了73个海葵新表达序列标签，有24个全长cDNA，其中包括海葵细胞毒素、海葵神经毒素、绿色荧光蛋白等具有开发应用价值的新基因。

Agkistrodotoxin, a presynaptic neurotoxin and one of the two neurotoxins from the snake venom of Agkistrodon halys Pallas, has been further purified by DEAF -cellulose and CM-Sephadex column chromatography and vertical slab polyacrylamide gel electrophoresis.

本文在前文的基础上，改进了蝮蛇神经毒素的分离方法，纯化了蝮蛇毒中的两个神经毒素之一，突触前神经毒素Agkistrodotoxin，并对其生化特性进行了分析。

Botox is the marketing name given to a neurotoxin called botulinum toxin A.

肉毒杆菌是一种叫肉毒菌毒素的神经毒素。

Studies on the function of the recombinant sea snake neurotoxins showed biological activity difference between the short-chain and long-chain neurotoxins.

对重组平颏海蛇神经毒素的功能研究表明短链与长链神经毒素的生物活性存在差异。

The book comprehensively reviews the molecular and cellular biology of the most important microbial toxins with a focus on recent advances in the field, covering topics such as toxin ADP-ribosylation of proteins, toxin inhibition of protein synthesis, modulation of actin cytoskeleton, cytolethal distending toxins, cell-damaging/pore-forming toxins, clostridial neurotoxins, toxins of the immune system, streptococcal and staphylococcal toxins, anthrax toxins, Shiga toxin, Yersinia toxin, mycotoxins, and the regulation of toxin expression, as well as the potential of microbial toxins in bioterrorism.

该书全面评论了最重要的微生物毒素的分子与细胞生物学，重点是这一领域中的最新进展，主题包括蛋白质毒素ADP核糖基化，毒素抑制蛋白质合成，肌动蛋白细胞骨架的调控，细胞致死增加毒素，细胞损伤/孔状毒素，梭菌属的神经毒素，免疫系统的毒素，链球菌和葡萄球菌毒素，炭疽毒素，Shiga毒素，Yersinia毒素，毒枝菌素，和毒素表达调节，以及生物恐怖中微生物毒素的潜在可能性。

In the second part of work, a basic peptide with mass weight of 7597 Da was isolated and purified from the Naja naja atra venom .

论文的另一部分工作通过对眼镜蛇毒进行分离纯化，获得了一个&极性很强&的组分，通过蛋白测序和分子量测定，组分确定为一个弱神经毒素，该毒素二级结构稳定，神经毒性很低。

When the effect ofNTP was examined after depletion of monoamines in the spinalcord by intrathecal neurotoxins, the antiallodynic and antihyperalgesiceffects were still observed after serotonergic denervation,but not after noradrenergic denervation.

鞘内给予神经毒素耗竭脊髓单胺递质后检查 NTP 的作用时，去除5羟色胺能神经支配后 NTP 的抗触觉性痛感和抗痛觉过敏作用仍然存在，但是去除去甲肾上腺素能神经支配后则消失。

Antinociception and VGSC-modulation of BmK IT2 and BmK AS—1. The results from nociceptive flexion reflex and plantar radiation heat showed: BmK IT2 (a depressant insect-selective neurotoixn) and BmK AS-1 (a new-type β-1ike neurotoxin) have significant antinociceptive effects on rat peripheral nerve system. The antinociceptive effects of BmK IT2 on the carrageenan-inflamed rats were significantly stronger than those on the normal rats. Whole-cell patch-clamping showed: Both TTX-S and TTX-R Na〓 currents induced from rat DRG neurons were significantly inhibited by BmK IT2 and BmK AS—1, and BmK IT2 was more sensitive to TTX-R than TTX-S component. All the results suggested: the peripheral antinociception of BmK IT2 and BmK AS—1 might be attributed to the inhibitory effects of them on the TTX-S and TTX-R Na〓 channel located on the peripheral ends of rat DRG neurons with small diameter.

中文题名特异性钠通道调制剂－长链蝎神经毒素的药理功能研究副题名外文题名 The study of pharmacological function of the specific modulators on voltage-gate Na+ channel-long chain scorpion neurotoxin 论文作者谭智勇导师吉永华研究员学科专业生理学研究领域\研究方向学位级别博士学位授予单位中国科学院上海生命科学研究院学位授予日期2002 论文页码总数93页关键词神经毒素毒理学电压门控钠通道东亚钳蝎钠通道调制剂馆藏号BSLW /2003 /R338 /22 本论文工作利用细胞和行为药理技术系统地研究了东亚钳蝎长链神经毒素的抗伤害性效应、对电压门控钠通道的电生理调制作用、改变胞内离子浓度的效应，并分析了相关的药理功能机制。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。