神经外的

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

And the reasonable proposal for the construction the region electrical power system was put forwardThe power load forecast is the basis of the power system planning.With the actual planning of regional development,uses a scientific and effective load forecasting methods forecast plans the local load electric quantity,is an important work to the regional power system planning.This dissertation uses the BP algorithm, proposed a double hidden layer structure artificial neural network to the forecast ultra-short-term power system load.After the simulation with the actual data,the method which this dissertation proposed compared to the traditional linear extrapolation Prediction method average absolute percent error of 2.5 percentage points,ten minute load forecasts achieve the average absolute percentage error are smaller than 2.5%accuracy.

本文利用人工神经网络BP算法，提出了一种双隐层结构的电力系统超短期负荷预测方法，经过对实际数据的仿真实验，本文提出的神经网络超短期负荷预测方法比传统的线性外推法预测平均绝对百分误差降低2.5个百分点，十分钟负荷预测达到平均绝对百分误差小于2.5%的精度。

The neurohypophysis is only found in the dorsal region between the RPD and the PPD. The growth hormone cells do not differentiate in the PPD of the adenohypophysis, occupying 2/3 of the PPD until the larva is 5 days old. The other hormone-producing cells in the RPD and in the PT do not differetiate. In the 10-day old larva, the hormone-producing cells except the GH cells in the adenohypophysis do not differentiate. In 15-day old larva, the adrenocorticotropic hormone cells differentiate in the RPD and the other hormone-producing cells in the adenohypophysis do not differentiate. In the 30-day old larva, the all kinds of hormone-producing cells are formed in the adenlhypophysis.

神经垂体只见于RPD和PPD交界的背上方。5日龄仔鱼腺垂体内GH细胞已分化，占PPD的2/3，其他激素分泌细胞未见分化。10日龄仔鱼脑垂体内除GH细胞外，未见其他种类激素分泌细胞分化。15日龄仔鱼脑垂体RPD内ACTH细胞已分化，PPD和PI内除GH细胞外，其他种类激素分泌细胞均未分化。30日龄仔鱼RPD、PPD和PI内各种激素分泌细胞都已分化，共有6种激素分泌细胞，分别是促肾上腺皮质激素分泌细胞，催乳激素分泌细胞，生长激素分泌细胞、促甲状腺激素分泌细胞、促性腺激素分泌细胞和促黑激素分泌细胞。

GDNF has been reported to exhibit trophic actions on various neurons of central nervous system and peripheral nervous system .

GDNF对中枢及外周的多种神经元有神经营养作用，与目前已知的神经营养因子相比，GDNF对受到损伤的多巴胺能神经元和运动神经元的促存活作用最为显著。

However, a growing number of studies suggest that excessive extracellular glutamate and resultant overstimulation of its receptors cause excitotoxic roles and lead to neuronal damage in several pathological conditions such as cerebral ischemia. Normally, the excitatory postsynaptic roles of glutamate are terminated by the activities of high-affinity sodium dependent glutamate transporters that locate on neuroglial cells and neurons near the synaptic cleft, which are thought to play important roles in inactivating released glutamate and keep it below toxic levels in the extracellular space.

在生理状态下，突触间隙中谷氨酸的清除取决于邻近神经胶质细胞及神经元上高亲和力、钠依赖性谷氨酸载体的活动，通过该载体的再摄取机制保持细胞外谷氨酸浓度于正常范围，这在预防谷氨酸的神经毒中起着重要的作用。

Objectives A rat model sciatic nerve crush injury was reproduced in rat, and behavioral changes, pain threshold, thermal withdrawal latency and the changes in c-fos expression in cornu dorsale medullae spinalis were examined, and the relationship between peripheral nerve regeneration and hyperpathia was explored.

目的 建立大鼠坐骨神经挤压模型，观察其神经恢复过程中行为学、机械痛阈值、热缩足反射潜伏期以及脊髓背角c-fos表达（对c-fos表达产物：Fos蛋白阳性的神经元进行计数）的改变，探讨外周神经损伤再生与痛觉过敏的关系。

I think WHO grade I dysembryoplastic neuroepithelial tumor is the most likely diagnosis, but one would like to see isolated floating neurons in the microcysts in addition to the small oligodendrocyte-like cells and neuropil-like fibrillary matrix.

我考虑可能是WHOI级的DNT（胚胎发育障碍的神经上皮肿瘤）。但DNT中除了少突胶质细胞样的小细胞和神经毡样胶质纤维基质外，还应该见到微囊中漂浮的神经元。

Conclusion. The authors believe that epidural venous enlargements should be considered as a cause of radicular and/or back pain in patients with anomalies of the inferior vena cava, because pathologic processes compressing nervous structures can cause pain.

作者认为硬膜外静脉曲张应该视为下腔静脉异常的病人神经根痛和/或背痛的一个原因，因为病态的突起压迫神经结构会导致疼痛。

The level of neuromuscularblockade was assessed by recording the amplitude of compoundmuscle action potentials (T1) from the abductor hallucis brevismuscle in response to supramaximal electrical stimulation ofthe median nerve at the wrist.

通过记录对腕部正中神经超强电刺激的反应中的拇外展短肌复合肌肉动作电位(T1)的幅度来评估神经肌肉阻滞的水平。

In the first part of this dissertation, positional distributions of overlapping trimers are focused. Artificial neural network , genetic algorithms and Markov model have been applied to DNA sequence motif finding problems by developing neural network model and Markov model for recogniting these DNA sequence motif.

本文第一部分采用人工神经网络、遗传算法和马尔科夫模型这三种模式识别算法，对启动子、外显子和内含子序列中核苷酸联体的分布特性作深入探讨，发现其中的某些普遍规律，并建立识别这些DNA序列基元特征模式的神经网络模型或马尔科夫模型，已成功用于未知序列的预测。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。