神经内的

Firstly, the establishment of model requires sophisticated neurointerventional techniques and costly interventional materials(sacculus, minikin circlip ring, endovascular electrocoagulation), it not only consumed time but also increased the resesrch expense ; Secondly, although the Massoud model is the first successful model that contain the nidus, but it is far from mimicking the high-flow fistulae frequently observed in a brain AVM; Thirdly, the rapid spontaneous thrombosis result in fistula occlusion in a short time;Fouthly, the model's natural course and the long–term patency of fistula are unclear;Currently the model is only used for the short-term research.

但Massoud模型目前存在以下主要缺点：第一，模型的建立需要复杂的神经介入技术和昂贵的介入材料(球囊、微弹簧圈、血管内电凝等)，操作费时，又大大增加了研究费用；第二，Massoud模型虽然首次具备了畸形血管团，但它远不是我们临床上常见的含有高流量动静脉瘘的脑AVM；第三，颈动静脉吻合口自发性血栓形成进而导致引流静脉闭塞的机率很高；第四，Massoud模型的长期自然过程和动静脉吻合口的长期通畅性尚不清楚，目前仅仅作为急性期模型。

It employs the complex-valued step function to build neural model, then constructs network structure and decides the number of neurons; it adopts complex-valued Hebbian rules and inner product way to calculate the net weight matrix; then it analyzes the convergence of the network by taking advantage of the definition of energy function. In the image pre-processing stage, 2-dimensional Fourier Transform and Euler's formula are used, respectively, to transfer a gray-scaled image into phase information needed by the complex-valued neural network when stores the traffic sign. In the image post-processing stage, phase inverse transformation is used to change the phase image to gray-scaled image.

采用复数阶跃函数构建了神经元模型，建立了复数Hopfield神经网络结构，并且确定了网络中神经元的个数；借助复数Hebbian学习规则和复数内积法给出了网络权值的确定方法；借用复数网络能量函数的定义，说明了复数识别网络的收敛性；在前期的图像数据处理部分，分别使用离散二维傅里叶变换和欧拉公式，给出了将灰度图像数据转化为复数网络所需要的相位信息的方法，实现了网络对路牌的记忆存储；在后期的图像还原部分利用相位逆变换的方法，实现了相位图到灰度图转化。

Of portions of the electric fluid, too minute to be discovered even by the delicate electrometer..., and he has detected in the metals, which Dr Galvani considered as mere agents in conducting his animal electricity, that very existing principle which the Doctor and his followers had overlooked.

什麼时候给电气的流体的部分的行动征服的神经，太微小不能透过精美的electrometer 甚至发现。。。，并且他已经在金属内发现，在非常传导他的动物电，那方面认为仅仅代理人的Galvan医生和他的随从者已经忽略的现有的原则。

The GFAP is a specific marker of astrocyte, its expression is more higher in the activity astrocyte, and finally the GFAP become the main composition of scar formations. The S -100 is a kind of acidity, dissolubilites, low molecular quantity and calcium hydronium conjugated protein, and it is mainly existed in neuroglial cell and schwann cell. It can promote the growth of axon, glial hyper-plasia and nerve divide and calcium's stability inside of cell, thus regulatin g the shape and metabolism of astrocyte . The quantity of S -100 protein and the degree of ischemia have direct proportion .

胶质纤维酸性蛋白是星形胶质细胞的特异性标记物，在活性星形胶质细胞中GFAP的表达相对更高，且最后GFAP成为胶质疤痕的主要成份。S-100蛋白是一种酸性、可溶性、低分子量的钙离子结合蛋白，主要存在于胶质细胞和雪旺细胞中，它可促进轴突生长、胶质增生、神经分化和细胞内钙的稳定，从而调节星形胶质细胞的形态和代谢。S-100蛋白与缺血的程度是成正比的。

The equipment has crept forward in its technology since Robin and his merry men had the run of Sherwood Forest, but the sport of archery remains essentially unchanged, A recurve bow coated in fiberglass has become standard, and arrows made of aluminium and carbon graphite can travel more than 240km/h, but the most important repuirements are straight forward: steady hands, strong shoulders, flexible muscles, sharp eyes and nerves of steel.

与罗宾汉和他的手下在舍伍德森林中占山为王的时代相比，射箭运动的器材装备在技术上已经逐渐进步不少，但是这项运动在本质上并没有改变。覆盖着玻璃纤维，向内凹进的弓已经成为了标准用具，用铝和石墨制成的箭时速可高达240公里。然而，最关键的要求还是那么简单：稳健的双手、强有力的肩膀、柔韧的肌肉、犀利的眼睛和钢铁一般的神经。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

We found that 1 mutant EG4 cells showed typical characteristics of pluripotent stem cells which had no obvious difference with wild cells; 2 When induced by 10〓 M retinoic acid , mutant EG4 cells differentiated into adipocytes with high frequency compared with mutant cells, suggested that EGFR plays a role in adipocyte differentiation; 3 when injected into nude mice, mutant teratocarcinomas contained a large amount of connective tissues as well as skeletal muscle, while wild EG4 cells produced frequently cartilage, keratinocyte and neuroepithelium.

我们建立了稳定表达胞内区功能缺失的外源EGFR cDNA片段的EG4细胞，分析其生长分化特性，发现 1）突变型细胞可在未分化状态下维持长时间的增殖，表明EGFR对EG多能干细胞表型无明显影响；2）〓 M的维甲酸A(retinoid acid A，RA)诱导后，大部分对照组细胞分化为脂肪细胞，而突变型细胞分化为脂肪细胞的比例明显较少，表明EGFR在脂肪细胞的发育分化中具有一定的调节作用；3）畸胎瘤切片分析显示，突变型瘤组织分布有大量的未分化细胞和结缔组织，分化细胞以肌肉细胞为主；对照组瘤组织含丰富的角质上皮、软骨、神经管等依赖EGFR的分化组织。

Minocycline represses diabetes-induced inflammatory cytokine production, reduces the release of cytotoxins from actiated microglia, and significantly reduces measurable caspase-3 actiity within the retina.

二甲胺四环素抑制糖尿病诱导的炎性细胞因子的产生，降低来自于活化的小神经胶质细胞的细胞因子的释放，同时显著降低视网膜内可检测的caspase-3的活性。

The results showed that a large amount of dense precipitate occurred at the medullary sheath and mitochondria in the periaqueductal grey and hypothalamus after the application of electroacupuncture or injection of morphine and T...

电子探针x-射线显微分析证明，这些沉淀颗粒的主要成份是钙。结果提示，从Ca~(2+)分布的改变看，电针、吗啡和Tb~(3+)的镇痛作用十分相似，三者的镇痛效应可能是通过神经细胞膜内、外Ca~(2+)的移动来调控的。

Objective To investigate whether tyrosine protein kinases Src and Fyn were involved in the phosphorylation of NR2A induced by cerebral ischemia followed by reperfusion. Methods Transient (15 min) brain ischemia was induced by the four-vessel occlusion in Sprague-Dawley rats. The antisense oligodeoxynucleotides of Src and Fyn were used to suppress the expression of Src and Fyn by intracerebroventricular infusion once a day for 3 days before ischemia.

近年来，最受人们关注的缺血性脑损伤机制是兴奋性氨基酸（excitatory amino acid， EAA）的神经毒性作用及神经元内钙超载触发的级联反应［1］，其中NMDA受体的NR2亚基在缺血性脑损伤中起着非常重要的作用，在缺血/再灌注（ischemia/ reperfusion，I/R）过程中其蛋白表达、磷酸化水平均有改变。

It seems likely that Kraft will return with a better offer.

看起来卡夫要重新考虑一个更好的出价了。

But he'd rather burn off my feelers and watch me squirm.

可他却放任那个家伙对我为所欲为！