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The epilepsy model induced by kainic acid is a dynamical model condition. 5-7 days after acute seizure episodes induced by a single systemic injection of a convulsant dose (10mg/kg) of KA the rats developed a long-lasting increase in seizure susceptibility and the characteristic histopathological features in the hippocampus similar to human TLE. So the KA model has been a well-known model to study TLE or intractable epilepsy.

颞叶癫癎红藻氨酸(kainic acid,KA)模型具有明确的动态变化过程,一次全身性给予惊厥剂量(10mg/kg)KA诱发SD大鼠急性癫癎发作后5-7天,动物开始出现癫癎发作敏感性长期增强,脑内亦发生与人类颞叶癫癎相似的神经病理、神经生化及神经分子生物学方面的改变,因此被认为是研究颞叶癫癎和难治性癫癎的理想模型之一。

The ubiquitin positive dystrophic neurites and neuronal intranuclear inclusions in frontal and temporal cortex as well as in limbic system might be a pathological basis in the development of psychiatric symptoms.

额叶、颞叶和扣带回皮层出现神经细胞核内包涵体或营养不良性神经突起可能是精神异常的病理学基础。

B, Ulnar nerve has been retracted posteriorly, and medial epicondyle is being freed.

从内上髁后方的尺神经沟中游离尺神经,并向后方牵开。

The hippocampus is falling sickness relevance brain area, Nerve peptide Y is that self own is generally acknow- ledged have the anti-epileptic effect nerve peptide within the brain.

海马是癫痫相关脑区,神经肽Y(Neuropeptide Y,NPY)是脑内具有抗癫痫作用的神经肽己被公认。

EAA neurotransmitter Gly increased the sensitivity of the ligand Asp and Glu to theNMDA receptor, thus increased the NMDA receptor activity and cytosolic Ca2 + in the bilirubin precipi-tated brain tissue. NMDA receptor antagonist GAPA could prevent the cytosolic Ca2 + overload, and re-lieve brain edema.

NMDA受体过度活化致细胞内Ca2+超载参与介导胆红素神经毒性,NMDA受体拮抗剂可望成为胆红素神经毒性防治的重要途径。

It has done a lot investigation on the microneurosurgery technique and monodrama operations, performed different kinds of complicated and difficult operations successfully such as resection of cranial basis tumors , cerebrovascular disease, resection of pituitary tumor by nose way , resection of spinal cord tumors, spinal cord congenital malformation .

是国内较早开展显微神经外科手术单位之一。在显微神经外科技术和微创手术方面做过许多研究,成功完成了各种神经外科疑难与复杂手术,如颅底肿瘤的显微手术、脑血管病的微创与介入手术、经鼻蝶入路垂体瘤切除手术、脊髓髓内肿瘤、脊髓先天性畸形的显微手术等。

The neurohypophysis is only found in the dorsal region between the RPD and the PPD. The growth hormone cells do not differentiate in the PPD of the adenohypophysis, occupying 2/3 of the PPD until the larva is 5 days old. The other hormone-producing cells in the RPD and in the PT do not differetiate. In the 10-day old larva, the hormone-producing cells except the GH cells in the adenohypophysis do not differentiate. In 15-day old larva, the adrenocorticotropic hormone cells differentiate in the RPD and the other hormone-producing cells in the adenohypophysis do not differentiate. In the 30-day old larva, the all kinds of hormone-producing cells are formed in the adenlhypophysis.

神经垂体只见于RPD和PPD交界的背上方。5日龄仔鱼腺垂体内GH细胞已分化,占PPD的2/3,其他激素分泌细胞未见分化。10日龄仔鱼脑垂体内除GH细胞外,未见其他种类激素分泌细胞分化。15日龄仔鱼脑垂体RPD内ACTH细胞已分化,PPD和PI内除GH细胞外,其他种类激素分泌细胞均未分化。30日龄仔鱼RPD、PPD和PI内各种激素分泌细胞都已分化,共有6种激素分泌细胞,分别是促肾上腺皮质激素分泌细胞,催乳激素分泌细胞,生长激素分泌细胞、促甲状腺激素分泌细胞、促性腺激素分泌细胞和促黑激素分泌细胞。

Moreover, using the intracerebral injection of LTA to evaluate the direct effect of LTA on developing microglia, we showed that ramified microglia labelled with OX-42 or ED-1 progressively retracted their processes then became amoeboid form, indicating that microglia were activated in response to LTA.

另外,利用脑内注射脂壁酸来探讨脂壁酸直接刺激小神经胶细胞的反应,结果显示在注射处有些受OX-42和ED-1标志的分枝状小神经胶细胞,渐渐的收回突起转变成圆形,显示小神经胶细胞有被活化的情况。

RESULTS:Immunogold particles for IRE1 could be identified in RGCs of the retin...

IRE1在RGC与少突胶质细胞内胶体金标记颗粒分布部位距离ER管腔距离增加为特征,在钳夹0.5d内神经干少突胶质细胞以及视网膜RGC内均表现非常明显的距离增加。

Methods: Neuroepithelial stem cells derived from the embryonic neural tube of GFP transgenic mice were cultured and depurated in free serum medium containing B27, bFGF and EGF, and then they were directionally transplanted into the striatum of rats.

将GFP转基因鼠的胚胎神经上皮干细胞置于无血清培养基内纯化扩增,用巢蛋白免疫组织化学染色鉴定神经干细胞,将扩增后的含GFP基因的神经干细胞在立体定位仪下,定向移植到大鼠的纹状体内。

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