神经元的

After that we give a presentation of ion lysenkoism which describe the potential change between the two sides of membrane and present the Hodgkin-Huxley model and it\'s equations set.We introduce the basic conception of stochastic resonance and coherence resonance subsequently.

然后，给出了神经元的基本知识，包括神经元的基本结构，神经元细胞膜离子浓度的分布，离子电位梯度和平衡电位，神经元的静息电位、动作电位，接着本文给出了描述神经元膜两边电压变化的离子学说及Hodgkin-Huxley模型和它对应的方程。

The results showed that:(1) The characteristic frequency of IC neurons of house mouse was increased with increasing recording depth, and the masker intensity used was positive relevant to the IC neurons\' minimum threshold. When the minimum threshold was high, the masker intensity needed was loud, vice versa.(2) According to the masking rate at MT+10dB of IC neurons to frequency modulation and tone burst, the IC neurons were classified as three types: type I neurons ( 72/113, 63.7%), in which the masking effect of TB was better than frequency modulation ;type II neurons (32/113, 28.3%), in which the masking effects of the two maskers were same; type III neurons( 9/113, 8.0%), in which the masking effect of FM was better than TB.(3) Type I neurons, the minimum threshold of which was low, but the Q_(10) and DR values of which were large; in type III neurons, the minimum threshold was high, the Q_(10) and DR values were narrow; in type III neurons, the MT Q_(10) and DR values were in between.(4) Both FM and TB could make the MT of type I neurons shift upward distinctively, but the effect of TB was more significant than FM.(5) The Q_(10) values of type I neurons became narrower under the influence of TB, were unaffected under the influence of FM.

结果显示：(1)小鼠下丘神经元的特征频率随着记录深度的增加而增高，掩蔽声强度与神经元的最小阈值呈正相关，即对高最小阈值的神经元进行掩蔽时需要的掩蔽声强度高，对低最小阈值神经元进行掩蔽需要的掩蔽声强度低：(2)根据调频声(frequency modulation， FM)和短纯音(tone burst， TB)对下丘神经元阈上10dB处反应的掩蔽，将小鼠IC神经元分为三类：Ⅰ类神经元(72/113，63.7％)，短纯音的掩蔽效果比调频声更好；Ⅱ类神经元(32/113，28.3％)，两者对神经元声反应的掩蔽率相同；Ⅲ类神经元(9/113，8.0％)，调频声的掩蔽效果更好；(3)Ⅰ类神经元的最小阈值低、Q_(10)值和动态范围大，Ⅲ类神经元最小阈值高、Q_(10)值和动态范围小，Ⅱ类神经元的最小阈值、Q_(10)值和动态范围介于Ⅰ和Ⅲ类神经元之间；(4)短纯音和调频声都可以使Ⅰ类神经元声反应的最小阈值明显上移，但短纯音使神经元最小阈值的上移更显著：(5)短纯音使Ⅰ类神经元的Q_(10)值变小，调频声使神经元的Q_(10)值增大不显著，短纯音与调频声对神经元Q_(10)的影响差别显著；(6)短纯音与调频声都使神经元的动态范围减小，并且作用显著，但短纯音的效果更显著：(7)短纯音与调频声都使神经元反应的潜伏期延长，效果显著，但TB的延长作用更为显著；(8)随着探测声强度的升高，短纯音和调频声对Ⅰ类神经元声反应的掩蔽率都降低，但在各个探测声强度短纯音的掩蔽率都比调频声高。

Based on extended Linsker's network developed by Wimbauer et al.,we build a model for the receptive field of toad's R3 ganglion cell and a model for the receptive field of the nLM neuron of pigeon. Computer simulations on the 'head/tail preference' property,the configurational selectivity of the R3 neuron,and the selectivity for contrast,direction,orientation and the length of the moving edges of the nLM neuron,have been made. The simulation results are consistent with the physiological experiments qualitatively.

为揭示这类神经元的信息加工原理，以Wimbauer等人提出的时延Linsker网络为基础，通过将不同的时空动态感受野线性组合，建立了蟾蜍视神经节R3类神经元和家鸽扁豆核神经元的感受野模型，并模拟了R3神经元对蠕虫样刺激物的"头/尾偏爱"特征，细胞对刺激物的构型选择性以及nLM神经元对运动边缘的反差、方向、边缘朝向和长度的选择性。

Keywords: Neural network, Competitive learning, Vector quantization, Neuron underutilization, Algorithm

与传统竞争学习算法只有一个神经元获胜而得到学习不同，PSCL算法按照各神经元的获胜概率并通过对失真距离的调整使每个神经元均得到不同程度的学习，可以有效地克服神经元欠利用问题。

The newborn neurons distributed throughout the telencephalon, mainly in the neostriatum caudale, and pars medialis;(3) Ultrastructural observation showed that newborn neurons in the NCM had the same morphologic characteristics as mature neurons and they formed synaptic connections with distant targets.

这些神经元不均匀分布在端脑的全部。新纹状体尾端中部是新生神经元的富集区；③电镜观察表明，NCM脑区中的新生神经元具有一般神经元特征并与周围神经元形成突触。

In the visual system, 5-HT/TPH-like immunoreactive neurons (ca.35 per hemisphere) were mainly situated between the optic lobe and lateral protocerebrum, the neurites of which either descended into the optic neuropils or ascended into the protocerebrum, thus possibly integrating the optic lobes and other brain regions.

TPH阳性神经元的类型、数目、分布位置、投射区域与5-HT基本相同。5-HT/TPH阳性神经元在视觉系统主要分布于视叶与侧前脑之间，每侧大约有35个，其轴突及分枝或下行进入视叶或上行进入前脑。5-HT/TPH阳性神经元在前脑分布于前脑背方、肯氏细胞两侧，大约有25个，轴突主要投射到蕈形体和中央复合体的广泛区域，另有个别神经元轴突下行投射进入视叶形成广泛分枝。

In the visual system, 5-HT/TPH-like immunoreactiveneurons (ca.35 per hemisphere) were mainly situated between the optic lobe and lateralprotocerebrum, the neurites of which either descended into the optic neuropils or ascendedinto the protocerebrum, thus possibly integrating the optic lobes and other brain regions. Inthe protocerebrum, 5-HT/TPH-like immunoreactive neurons (ca. 25) mainly distributed dorsalto the protocerebrum beside the Kenyon cells. Their axons directly projected into theprotocerebrum as well as the optic lobe.

TPH阳性神经元的类型、数目、分布位置、投射区域与5-HT基本相同。5-HT/TPH阳性神经元在视觉系统主要分布于视叶与侧前脑之间，每侧大约有35个，其轴突及分枝或下行进入视叶或上行进入前脑。5-HT/TPH阳性神经元在前脑分布于前脑背方、肯氏细胞两侧，大约有25个，轴突主要投射到蕈形体和中央复合体的广泛区域，另有个别神经元轴突下行投射进入视叶形成广泛分枝。

Get the neonate Sprague-Dawley rats medulla spinalis, through the conventional primary cell culture procedure, we use the method of difference adherence time and get the motor neurons of anterior spinal cord. When the neuron is in maturity, we make the mechanical injury model in vitro. All the models were divided into four groups: group A is control group; group B is 100μM ATP group; group C is 100μM ATP+20μg/ml suramin group and group D is 100μM ATP+10μM ouabain+10μg/ml Thapsigargin group. Culture the four groups neurons, after one day, we count the motor neuron, observe the survival and activity of neurons through MTT shade selection experiment, use flow cytometry to analyze the percentage of apoptosis of motor neurons of anterior spinal cord and detect the expression of protein p-GSK-3β(ser9) through Western-Blot technology.

方法取新生大鼠脊髓，通过常规的原代细胞培养程序，采用差速贴壁法分离出大鼠脊髓前角运动神经元，培养成熟后制作神经元机械损伤体外模型，分为A组：对照组、B组：100μMATP组、C组：100gMATP+20μg/ml Suramin组和D组：100μM ATP+IOμM Ouabain+10μg/ml Thapsigargin组，对各组机械损伤的运动神经元进行培养，1天后分别进行运动神经元计数、MTT比色实验观察运动神经元的存活及活性、流式细胞仪分析机械损伤的脊髓前角运动神经元凋亡百分率和Werstern Blot技术检测p-GSK-3β(ser9)的表达。

Kangdai Ⅰ has protective function to the damaged neurons and astrocytes: Main results:(1) It has direct protective function to the damaged neurons. It can increase the activity and survival rate, decrease the mortality and the transudation rate of LDH in cultured medium and the strong positive cell count of NOS expression of injured neurons.(2) It has also directly protective function to the damaged astrocytes. It can increase the activity and survival rate and protein content in conditioned medium.(3) It can strengthen the ability of BDNF, GDNF, bFGF, HSP and IL-6expression in damaged astrocytes.(4) It can also strengthen obviously the expressions of NSE, bFGF-receptor and bc1-2, lower the expression of bax and caspase-3.(5) It can indirectly protect and restore the damaged neurons by astrocytes. Because the effect of ACMK (ACM interfered by Kangdai Ⅰ) is stronger than ACM+K (ACM associated with Kangdai Ⅰ).

抗呆Ⅰ号对受损的神经元和星形胶质细胞均具有保护作用：主要表现为：(1)对受损神经元具有直接的保护作用，可提高受损神经元的活性和存活率，降低细胞培养液LDH的漏出率、细胞死亡率和NOS染色强阳性细胞的表达量；(2)对受损的星形胶质细胞也有直接的保护作用，可提高其活性、存活率以及培养液蛋白质的含量；(3)能增强受损星形胶质细胞分泌BDNF、GDNF、bFGF、HSP和IL-6的能力；(4)可明显增强受损神经元对NSE、bFGF的受体和bc1-2的表达，降低受损神经元对bax和caspase-3的表达；(5)抗呆Ⅰ号可通过星形胶质细胞间接地保护和修复受损的神经元，因为在多数实验组中经抗呆Ⅰ号作用的ACM的作用远大于ACM与抗呆Ⅰ号联合应用的作用，统计学上具有显著性差异。

Type II cells were mainly distributed in layer V of cortex. It appeared that these cells receive the CRF immunostaining fibers terminals afferent from other cells rather than synthesize CRF by themselves. It is probable that type II cells receive afferent fibers from both extracortex and type I cells within layers II -III cortex. Considered that Type I cells morphologically are inhibitory interneuron, we presumed that type I in layer II -III could inhibit activity of type II cells in layer V.

CRF阳性Ⅱ型细胞主要分布在皮层第Ⅴ层，形态学特征显示这类细胞更像是接收来自其它神经元的CRF纤维投射而非自身分泌CRF，证据显示Ⅱ-Ⅲ层CRF神经元纤维可进入第Ⅴ层，考虑到皮层的CRF神经元形态上为抑制性中间神经元，这些结果提示Ⅱ-Ⅲ层CRF神经元能够抑制第Ⅴ层神经元的活动。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。