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Following ISM superfusion, an agonal inward current was produced at a holding potential of -70 mV in all VH and DH neurons tested in voltage-clamp mode.

在电位箝模式中所有神经元在域电位-70mv时可见电流内流现象。

Rat in Group B was set an air bladder which was empty and not perfused water. Water of 0.6 ml, 0.8 ml, 1.0 ml, 1.2 ml, 1.4 ml and 1.5 ml was perfused respectively into the air bladders which were set in the colon of rats in group C, D, E, F, G and H. Then the changes of ethology of the rats were recorded in interval of an hour.

应用疼痛行为学的观察方法,观察1h各组动物的行为学改变,并采用免疫荧光化学的方法,观察大鼠DCN中神经元被激活的标志c-fos及胶质细胞的胶质原纤维酸性蛋白(glial fibrillary acidic protein, GFAP)和小胶质细胞特异性补体OX42的表达情况,空白对照组是在疼痛高峰点(1.2 ml)处死取材。

It has been demonstrated that the abnormal hypoactivity and synchronized rhythmic discharge of globus pallidus neurons associate with akinesia and resting tremor in parkinsonism.

已证实,苍白球神经元放电频率的降低及簇状放电的产生与帕金森病运动减少及静止性震颤等症状直接相关。

At baseline and on day 1, 3, 7, 14, 21 following MPP+ injection, the degree of microglial activation was examined by detecting the immunodensity of OX-42 in the substantia nigra. The number of viable dopaminergic neurons was determined by measuring tyrosine hydroxylase positive neurons in the SN. Behavioral performances were evaluated by counting the number of rotations induced by apomorphine, calculating scores of forelimb akinesia and vibrissae-elicited forelimb placing asymmetry.

分别在基线、MPP+注射后第1、3、7、14、21天时通过测定黑质区域OX-42的免疫荧光强度评定小胶质细胞的激活程度,测定酪氨酸羟化酶的表达情况评定存活多巴胺神经元的数量;通过阿朴吗啡诱导的旋转行为、前肢跨步及触须引发的不对称放置试验得分测评行为学表现。

At present there is no effective therapeutics to treat PD except the allopathy. The discovery of neural stem cells in the adult mammalian brain provides a new chance to effect a radical cure on PD. But how to make the limited neural stem cells proliferating enough and differentiating into the dopaminergic neurons which can repair the nigrostriatal pathway and help to eliminate the PD symptoms becomes an urgent problem.

成年动物脑内神经干细胞的发现为根治帕金森病提供了新的细胞源泉,但如何使有限的神经干细胞增殖到足够数量并转化为多巴胺能神经元,使之能够修复黑质纹状体通路,逆转帕金森病临床症状,是目前亟待解决的问题。

ABSTRACT:Objective To explore the effect of aluminium on hippocampal neurons.

目的 探讨金属铝对急性分离的大鼠海马锥体神经元的作用及其机制。

Objective To investigate the effects of aluminum on differentiation of rat neural stem cells in vitro.

目的 探讨铝对大鼠神经干细胞向神经元样细胞分化的影响。

At its core is a cluster of neurons deep in the brain known as the amygdala

扁桃核。该机制的核心是大脑内部的一束被称为扁桃核的神经元

To estimate the effect of the NO on the amygdaloid complex, we studied the origin of the NOS positive fiber terminals in the medial amygdaloid nucleus .

研究NOS在杏仁复合体传入投射神经元中的分布情况,为进一步研究NO在杏仁复合体调控伤害性信息中的作用提供形态学依据。

RESULTS: There was plentiful COX2 protein in the cortex, the hippocampus, the dentate gyrus, the supraoptic nucleus, the amygdaloid nucleus, cerebellum and brain stem, and so on.

结果:在正常成年大鼠脑内COX2蛋白主要表达于皮层、海马、齿状回、视上核、杏仁核、小脑和脑干等部位,阳性细胞主要为神经元,神经胶质细胞染色很少。

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