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In this dissertation,a new mechanism of stochastic resonance in the excitablesystem is presented,and the relationship between the stochastic resonance inexcitable neurons and the dynamic bistability is reported for the first time.Thepresent study deals with the extension of the concept of stochastic resonance,which has been thoroughly examined in bistable and simple excitable system,to amore complex system.It may even open the door to a better understanding ofstochastic resonance in neural system since experimental evidence supports theextension of such bistability in vitro preparations.

本文提出了可兴奋性系统中一种新的随机共振机制,首次报道了可兴奋性神经元中随机共振和动态双稳态的关系,将以前的单纯讨论双稳系统或可兴奋系统中的随机共振推广到了可兴奋系统中有动态双稳态更复杂的情形,由于在神经元的实验中已有关于动态双稳态的报道,本文所提出的随机共振为理解神经元中随机共振的编码机制开启了新的途径。

At histopathologic analysis, neuronal tumors are usually classified as pure neuronal cell tumors (gangliocytoma, Lhermitte-Duclos disease , central neurocytoma) and mixed neuronal-glial tumors (ganglioglioma, desmoplastic infantile ganglioglioma, dysembryoplastic neuroepithelial tumor, ganglioneuroma).

根据组织病理学的分析,神经元肿瘤通常被分为:单纯的神经元细胞肿瘤(神经节细胞瘤,Lhermitte-Duclos 病〔发育不良性小脑神经节细胞〕瘤),中枢神经细胞瘤)和混合性的神经元-胶质肿瘤(神经节神经胶质瘤,成结缔组织性婴儿节细胞胶质瘤,胚胎发育不良性神经上皮瘤,神经节瘤)。

GDNF may be related to the mechanism of neuronic injury and repairment. Protective effects of VPA may be involve in increasing expression of GDNF.

帕金森病小鼠神经元内GDNF含量增多,可能有利于受损神经元的修复;丙戊酸盐可能通过促进GDNF的表达而保护神经元

Their shapes were diversiform such as nummular, elliptic and oval etc. Positive neurons had one or several tubers and its axon was short. This experimentation results showed that development level of eNOS immunopositive neurons approach the adult rabbit when it is a young rabbit.

eNOS阳性神经元呈棕褐色,免疫阳性物质主要位于胞浆内,胞浆染色均匀,胞核处着色浅;神经元胞体形态各异,有圆形、卵圆形、椭圆等多种形状,神经元突起有一个或者数个,轴突较短。

And the Akt of activation carries gene of phosphation Bad, GSK-3, transcribe familial, IB, Caspases make close to wither dies gene misses work, have inhibitory nerve thereby yuan wither dies reach stimulative nerve yuan surviving action, reduce AD nerve then yuan many and missing, the pathology that improves AD changes.

而活化的Akt通过磷酸化Bad、GSK-3、转录因子家族、IB、caspases等使促凋亡基因失活,从而起到抑制神经元凋亡及促进神经元存活的功能,进而减少AD神经元的大量丢失,改善AD的病理变化。

The model of brain concussion of rat can be established successfully using iron pendulum hitting device; 2. The spatial learning and memory deficits of the rats are detected by MWM in early period post-BC(from 1 to 3 days after BC); 3. Pycnosis degeneration or necrosis neurons of the cerebral cortex, dorsal hippocampus, dentate fornix and brainstem reticular formation are identified in BC rats; 4. There are significantly changes in the number and activity of cholinergic neurons in the basal forebrain and brainstem reticular formation after BC; 5. The change of cerebral neurons and cholinergic neurons correlate with cognitive deficits in BC rats .

1、单摆式闭合性机械打击装置能成功建立脑震荡大鼠模型;2、脑震荡大鼠在MWM实验中出现早期空间认知行为障碍;3、脑震荡大鼠大脑皮质、背侧海马、齿状回和脑干网状结构出现程度不等的部分神经元固缩变性和不完全性坏死;4、脑震荡大鼠基底前脑、脑干网状结构ChAT活性表达有明显变化;5、脑震荡大鼠认知障碍与相关脑区神经元、胆碱能神经元的变化有关联。

MSG could insult the functions and structures of specific brain areas of adult mice through blood-brain barrier. The ability of discrimination learning in Y-maze was affected markedly, especially in 4. 0g/kg MSG group, meanwhile, dark pyknotic and loss of neurons were shown in arcuate nucleus of hypothalamus, but not in hippocampus. Consistent changes occured in mitochondrial membrane protein bound 〓 by 〓-fluoresent probe, i.

MSG可以透过成年小鼠血脑屏障产生神经毒性作用。4.0g/kg MSG对小鼠空间分辨学习能力的损伤程度较2.5g/kg MSG更为明显,同时下丘脑弓状核神经元出现核固缩及神经元数目明显减少,相同处理未引起海马神经元的明显变化。

Results The rubrospinal neurons were retrogradely identified by cholera toxin subuint B coulpled with colloidal gold (CB-Au,prepared by our laboratory).

结果 红核-脊髓投射神经元表现为两种亚型:一种为CaBP-LI阴性神经元;另一种为CaBP-LI阳性神经元

The weakly or strongly stained CaBP-LI/CB-Audouble-labelled cells gradually increased caudalward.In the middle rostrocaudal third of the red nucleus,the double-labelled neurons mainly occupied the ventromedial portions of the red nucleus.

两种神经元在红核具有特殊的分布方式,头侧水平CB-Au标认的红核-脊髓投射神经元均呈CaBP-LI阴性,向尾侧CaBP-LI阳性神经元数目逐渐增多。

The weakly or strongly stained CaBP-LI/CB-Audouble-labelled cells gradually increased caudalward.In the middle rostrocaudal third of the red nucleus,the double-labelled neurons mainly occupied the ventromedial portions of the red nucleus.

两种成年人神经元在红核具有特殊的分布方式,头侧水平CB-Au标认的红核-脊髓投射成年人神经元均呈CaBP-LI阴性,向尾侧CaBP-LI阳性成年人神经元数目逐渐增多。

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The split between the two groups can hardly be papered over.

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