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磺胺类药物

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Results: The proportion of Gram-negative bacilli rose obviously, so did the opportunistic pathogen's and Yeasts detected rate. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Citrobacter resistant and so on to fluoroquinolones was 57%~97%. These bacteria to imipenem showed excellent activity. Meticillin-resistant-staphylococcus resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, cefazolin and ampicillin were 40.9%, 42.4%, 63.6%, 72.2%, 85.9%, 100.0% and 100.0%, respectively Streptococcus and Enterococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonamides were between 36.0% to 100.0%.

结果:革兰阴性杆菌比例显著升高,条件致病菌和酵母样真菌检出机会显著增多;药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升;大肠埃希菌、沙门菌和枸橼酸杆菌等革兰阴性杆菌对喹诺酮类药物的耐药率达57%~97%,亚胺培南则对阴性杆菌有较高的敏感覆盖率;耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、头孢唑啉和氨苄西林的耐药率分别为40.9%、42.4%、63.6%、70.2%、85.9%、100.0%和100.0%;链球菌和肠球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物均呈高度耐药,耐药率在36%~100%。

To Dec. 2003 years in Yuxi city People's Hospital. RESULTS: The proportion of G- bacilli were much. The opportunistic pathogen's and Yeasts detected rate rose obviously. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Klebsiella and so on to fluoroquinolones was 50~97.7%. These bacteria to imipenem showed excellent activity. MRS resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, gentamycin, trimeth/sulfa and cefazolin were above 50%. Streptococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonomides were highness.

结果:G-杆菌比例居多,条件致病菌和酵母样真菌检出机会显著增高;药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升;大肠埃希菌、沙门菌和克雷伯菌等G-杆菌对喹诺酮类药物的耐药率在50%~97.7%,亚胺培南则对阴性杆菌有较高的敏感覆盖率;耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、庆大霉素、复方新诺明和头孢唑啉的耐药率均在50%以上,链球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物呈高度耐药。

A sulfa drug used like sulfadiazine and also in veterinary medicine.

用法像磺胺嘧啶的磺胺类药物也可以作为兽医药物。

A white odorless crystalline sulfa drug; the parent compound of most of the sulfa drugs.

一种白色无味的水晶状磺胺类药物;主要由磺胺药物制成的母体化合物。

Samples of animal manure were collected in Jiangsu Province in 2005 to 2006, the residues of sulfagidine, sulfanilamide, sulfadiazine, sulfamerazine(SM1), sulfadimidin(SM2), sulfamonomethoxine, sulfachloropyridazine, sulfamethoxazole were determined by HPLC with fluorimetric detector after pre-column derivatization.

2005—2006年采集了江苏省各市不同种类的集约化畜禽养殖场共178个畜禽粪便样品,用柱前衍生法高效液相色谱荧光检测器,检测了样品中8种磺胺类药物(磺胺胍、磺胺、磺胺嘧啶、磺胺甲嘧啶、磺胺二甲嘧啶、磺胺间甲氧嘧啶、磺胺氯哒嗪、磺胺甲恶唑)残留情况。

A method was developed for the determination of five sulphonamide residues (sulfamonomethoxine sodium, sulfamethazine, sulfamethoxazole, sulfadimethoxine and sulfachinoxalin) in meat by high performance liquid chromatography.

建立了高效液相色谱法测定猪肉中的磺胺间甲氧嘧啶、磺胺二甲基恶唑(SM2)、磺胺甲嘧啶、磺胺二甲氧嘧啶和磺胺喹恶唑五种磺胺类药物残留的方法。

Drugs (methimazole, methylthiouracil, propylthiouracil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole.

抗甲状腺?药物(他巴唑,甲基硫氧嘧啶,丙基硫氧和硫氧嘧啶);一些镇静剂(doxylamine琥珀和苯巴比妥),以及包括系统性真菌抗生素灰黄霉素,安体舒通的利尿一些其他药物,以及抗菌磺胺类药物和磺胺二甲嘧啶。

A UPLC method was established for the ten sulfonamides including sulfadiazine,sulfathiazole,sulfadimidine(SM2),sulfamethoxypyridazine,sulfachlorpyridazine,sulfamonomethoxine, sulfamethoxazole, sulfachloropyrazine (Esb3),sulfadimethoxine and sulfaquinoxaline in pig muscle and milk.

建立了猪肉和牛奶中磺胺嘧啶、磺胺噻唑、磺胺二甲嘧啶(SM2)、磺胺甲氧嗪、磺胺氯哒嗪、磺胺间甲氧嘧啶、磺胺甲基异噁唑、磺胺氯吡嗪(Esb3)、磺胺地索辛和磺胺喹噁啉共10种磺胺类药物残留检测的超高效液相色谱法。

Sulfa drugs, such as cotrimoxazole, isoxazole sulfonamides, sulfa Micronesia acridine, Sulfamethoxazole, Sulfonamides methoxy pyrazine, sulfonamides Formamidine, probenecid, double pyrimidine films, bacteriostatic sulfonamide, trimethoprim, sulfathiazole, such as amber.

磺胺类药物,如复方新诺明、磺胺异恶唑、磺胺密啶、磺胺甲基异恶唑、磺胺甲氧吡嗪、磺胺脒、丙磺舒、双嘧啶片、制菌磺、甲氧苄氨嘧啶、琥珀磺胺噻唑等。

As a kind of artificial molecular recognition materials ,the applications of imprinted polymers including in Chromatogram analysis and separate,SolidPhaseExtraction, emulational transducer and so on which were summarized in detail . Analytic technique of iatric ort was introduced briefly.

对药物残留分析技术也作了扼要的介绍,指出了利用分子印迹技术合成磺胺类药印迹聚合物来分离和测定磺胺类药物,对食品工业和制药工业的质量控制有十分重要的意义。

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