磺胺的

Objective: To develop a GC method for determination of acetone in sulfadimidine.

目的：建立磺胺二甲嘧啶合成中所用有机溶剂丙酮残留量的测定方法。

For example: antimalarials primaquine morpholine, flutter malaria quinoline, quinine, chloroquine, quinacrine; antibacterial drugs have sulfa drugs, chloramphenicol and furans; antipyretic analgesics are acetyl salicylic acid, phenacetin, acetanilide, antipyrine, aminopyrine; other drugs such as vitamin K, probenecid, hydralazine, quinidine, methylene blue, toluene and so on.

抗疟药伯氨喹啉、扑疟喹啉、奎宁、氯奎、阿的平；抗菌药有磺胺类药物、氯霉素及呋喃类；解热镇痛药有乙酰水杨酸、非那西丁、乙酰苯胺、安替比林、氨基比林；其它药物如维生素K、丙磺舒、肼苯哒嗪、奎尼丁、美蓝、甲苯等。

Hazard analysis sheet is not updated and potential hazards are not identified in part of raw materials e.g. heavy metal, benzene hexachloride and DDT in raw materials, heavy metal and toluene diamine in inner packaging materials.

危害分析表中对部分原料的不同危害未明确识别，如原料鲜奶(化学危害：六六六/滴滴涕/黄曲霉毒素/重金属/四环素/磺胺类等)和内包材甲苯二胺/重金属

Remedial group is in ammonia of armour of weekly profess to convinced butterfly Ling15mg foundation applies Yinaxipu, every periderm chip in is shot 2 times, every time 25mg; contrasts the MTX of same dose applies group profess to convinced jointly medicine of other change illness , pyridine of sulphanilamide of the nitrogen that be like willow or come fluorine rice is special.

治疗组在每周口服甲氨蝶呤15mg基础上联合应用依那西普，每周皮下注射2次，每次25mg；对照组口服相同剂量的MTX联合应用其他改变病情药，如柳氮磺胺吡啶或来氟米特。

The calibration curve of the SM2-Kit with standard SM2 inhibitor was typical sigmoid curve fitted to the four parameter logistic equation with the linear detection of 0.625 μg/L to 80.0 μg/L (R2=0.9911), the sensitivity of 0.9 μg/L, the IC50 of 5.82 μg/L and the detection limit of 1 μg/L. The recoveries of SM2 spiked in pig feed were 83.4 %, in pig urine were 89.5 %. The precision and accuracy of the assay as determined by inter-assay and intra-assay coefficient variation was both below 15 %. The SM2-Kit generally had 2.08 % cross-reactivity towards sulfamerazine and little or no cross-reactivity towards other sulfonamides. The dilution solution of SM2 had no effect on results of SM2-Kit. The validity of SM2-Kit in 4 ℃ was above six months.

研究结果表明，SM2-Kit的标准曲线呈典型的S型，相关系数R2=0.9911，符合4参数logit曲线拟合，线性检测范围为0.625 μg/L～80 μg/L，灵敏度为0.9 μg/L，半数抑制浓度(IC50)为5.82 μg/L，检测限为1 μg/L；饲料样、猪尿样的平均添加回收率分别为83.4 %、89.5 %，平均批内和批间变异系数均低于15 %；SM2-Kit与磺胺甲基嘧啶的交叉反应率为2.08 %，与其它磺胺类药几乎没有反应性；基质对SM2-Kit的检测结果影响不大；试剂盒在4 ℃可保存6个月。

In the study, N4 -acetyl-sulfamethazine(N4 -ACE-SM2) was synthesized, the determination method of sulfamethazine(SM2) and N4-ACE-SM2 in sturgeon muscle and water were developed, bioconcentration and depuration of SM2 in the sturgeon were completed at last.

本研究合成了磺胺二甲嘧啶(SM_2)的主要代谢产物N~4-乙酰化磺胺二甲嘧啶(N~4-ACE-SM_2)，并建立了SM_2和N~4-ACE-SM_2在鲟鱼肌肉和水中的检测方法，进一步利用流水式鱼类试验，对SM_2在鲟鱼体内的生物富集和生物清除进行了研究。

Molecularly imprinted polymers of sulfamethazine(SM 2 ) were prepared with silica gel as a sacrificial material, methacrylic acid and 4 vinylpyridine(4 Vp) as functional monomers, glycol dimethacrylate as crosslinker. The polymer properties were investigated by static adsorption experiments. Scatchard analysis shows that the adsorption ability of MAA MIP is superior to that of 4 Vp MIP. The dissociation constant of MAA MIP is 9 59×10 -4 mol/L. The value of apparent binding a...

以磺胺二甲嘧啶为模板分子，分别用甲基丙烯酸和4乙烯基吡啶为功能单体，二甲基丙烯酸乙二醇酯为交联剂，采用牺牲硅胶法合成了磺胺分子印迹聚合物，通过静态吸附实验，系统研究了不同单体对聚合物识别性能的影响；Scatchard分析表明，以甲基丙烯酸为单体的聚合物具有较高的吸附能力，其离解常数Kd为959×10-4mol/L，最大表观结合位点数Qmax为3070μmol/g。

A series of sulfanilamide group substituted derivatives were optimized on the basis of the semi-empirical quantum chemistry PM3 method.

以量子化学半经验PM3法对含磺胺基的一类有机化合物分子进行了几何构型优化，计算了分子的二阶非线性光学系数和电子转移，讨论了磺胺基在非线性光学材料设计中的特点和作用以及不同的取代基及取代位置对分子二阶非线性光学系数的影响

As a kind of artificial molecular recognition materials ,the applications of imprinted polymers including in Chromatogram analysis and separate,SolidPhaseExtraction, emulational transducer and so on which were summarized in detail . Analytic technique of iatric ort was introduced briefly.

对药物残留分析技术也作了扼要的介绍，指出了利用分子印迹技术合成磺胺类药印迹聚合物来分离和测定磺胺类药物，对食品工业和制药工业的质量控制有十分重要的意义。

Pharmacology function】Huang An the AN oxygen Mi Ding be in the Huang An medicine to suppress the germ a very strong kind of the function to synthesize anti-virus medicine, because of it with for germ to synthesize folic acid demand of to ammonia Ji the benzene be sour to have likeness on the structure, exchange with PABA to contend for two hydrogen folic acids to synthesize Mao, bar the germ synthesize two hydrogen folic acids to synthesize Mao, bar the germ synthesize two hydrogen folic acids, end influence nucleic acid protein of synthesize, repress thus germ of growth breed, to variety E-and E+very strongly repress a function.

磺胺间甲氧嘧啶是磺胺类药物中抑菌作用极强的一种合成抗菌药物，因其与细菌合成叶酸时所需要的对氨基苯酸在结构上具有相似性，与PABA兑争二氢叶酸合成酶，阻碍细菌合成二氢叶酸合成酶，阻碍细菌合成二氢叶酸，最终影响核酸蛋白质的合成，从而抑制细菌的生长繁殖，对多种E-及E+有很强的抑制作用。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。