磺胺甲嘧啶

Objective: To know the sulfonamides residue level of the animality food, inquiry into the source of its pollution, evaluate the safety of its meal, a high performance liquid chromatography method was developed for determination the sulfonamides residues of sulfadiazine, sulfamonomethoxinne, sulfamonomethoxine and sulfaquinxalin in pork.

目的：为了解动物性食品中兽药残留水平，探讨其污染来源，评价其膳食安全性，因此建立猪肌肉组织中磺胺嘧啶、磺胺甲恶唑、磺胺对甲氧嘧啶、磺胺喹恶啉残留量的高效液相色谱测定方法。

Objective:To develop a simultaneous determination the dissociation constant values of sulfamethoxazole ,sulfadiazine and trimethoprim, and the contents in their preparations by HPCE.

目的：采用毛细管电泳法测定磺胺甲嚼唑、磺胺嘧啶和甲氧苄啶的离解常数及其在制剂中的含量。

Sulfamonomethoxine was used as internal standard. Phenacetin, paracetamol and IS were monitored by multiple reaction monitoring mode with ion transitions of m/z 180→138, 152→110 and 281→156, respectively.

以磺胺甲氧嘧啶为内标，非那西丁、对乙酰氨基酚和内标的多反应监测离子对分别为m/z180→138、152→110和281→156。

The products include two series: Sulfa drugs Industrial Sulfanilamide, Crystel Sulfanilamide, Sulfaguanidine, Sulfadimidine(Sodium, Sulfadiazine, Sulfathiazole Sodium, Sulfaquinoxaline Sodium, Sulfameter Dimethyl Sulfate, Nitromethane, Hydroxylamine Hcl.

本公司专业生产化工、医药中间体，产品主要包括磺胺（工业磺胺、结晶磺胺、磺胺脒、磺胺二甲嘧啶、磺胺嘧啶、磺胺噻唑钠、磺胺喹噁啉钠、磺胺五甲氧嘧啶）及硫酸二甲酯（硫酸二甲酯、硝基甲烷、烟酸羟胺）两大系列。

A method for the determination of 12 sulfonamides (sulfanilamide, sulfamonomethoxine, sulfacetamide, sulfamethoxazole, sulfadiazine, sulfisoxazole, sulfathiazole, sulfadimethoxine, sulfamerazine, sulfaquinoxaline, sulfamethazine, sulfanitran) in cosmetics was developed by ultra performance liquid chromatography with photodiode array detector. The chromatographic column used was Acquity UPLCTM BEHC C18 (50 mm×2.1 mm, 1.7 μm) and the mobile phase was acetonitrile-0.1% formic acid aqueous solution.

建立了采用超高效液相色谱-二极管阵列检测器测定化妆品中12种常见的磺胺抗生素(磺胺，磺胺间甲氧嘧啶，磺胺醋酰，磺胺甲基异唑，磺胺嘧啶，磺胺二甲异唑，磺胺噻唑，磺胺二甲氧嘧啶，磺胺甲基嘧啶，磺胺喹啉，磺胺二甲嘧啶，磺胺硝苯)的方法。

Toxic effects of twelve pesticides（abamectin, endosulfan, diflubenzuron, danitol, tricyclazole, fluroxypyr, imazalil, tebuconazole, sulfapyridine, sulfamethoxazole, sulfamethazine and sulfadiazine）at low concentration（0.01mg·L-1） on the development of sea urchinembryos were investigated in this work, and the correlation between n-octanol/water partition coefficientand relative lethality rate was investigated.

为了研究低浓度下农药对海胆胚胎的毒性影响，以及正辛醇/水分配系数与致死率的关系，实验研究了12种常见农药（阿维菌素、硫丹、除虫脲、甲氰菊酯、三环唑、使它隆、抑霉唑、戊唑醇、磺胺吡啶、磺胺甲噁唑、磺胺二甲嘧啶和磺胺嘧啶）在低浓度（0.01mg.L-1）下对光棘球海胆胚胎发育的急性毒性影响。

A UPLC method was established for the ten sulfonamides including sulfadiazine,sulfathiazole,sulfadimidine(SM2),sulfamethoxypyridazine,sulfachlorpyridazine,sulfamonomethoxine, sulfamethoxazole, sulfachloropyrazine (Esb3),sulfadimethoxine and sulfaquinoxaline in pig muscle and milk.

建立了猪肉和牛奶中磺胺嘧啶、磺胺噻唑、磺胺二甲嘧啶（SM2）、磺胺甲氧嗪、磺胺氯哒嗪、磺胺间甲氧嘧啶、磺胺甲基异噁唑、磺胺氯吡嗪（Esb3）、磺胺地索辛和磺胺喹噁啉共10种磺胺类药物残留检测的超高效液相色谱法。

Sulfa drugs, such as cotrimoxazole, isoxazole sulfonamides, sulfa Micronesia acridine, Sulfamethoxazole, Sulfonamides methoxy pyrazine, sulfonamides Formamidine, probenecid, double pyrimidine films, bacteriostatic sulfonamide, trimethoprim, sulfathiazole, such as amber.

磺胺类药物，如复方新诺明、磺胺异恶唑、磺胺密啶、磺胺甲基异恶唑、磺胺甲氧吡嗪、磺胺脒、丙磺舒、双嘧啶片、制菌磺、甲氧苄氨嘧啶、琥珀磺胺噻唑等。

In endemic disease preventive medication over the period at risk using 500 to 800g of tetracycline or trimethoprim/sulpha 400g/tonne in-feed may be used but it would be advisable to identify the major bacteria involved and determine their antibiotic sensitivities.

在高风险期需针对地方性疾病采取预防性用药措施，可在每吨饲料中添加500至800克四环素或400克甲氧苄胺嘧啶/磺胺。但建议用药前分离确定主要的病源并进行药敏试验。

Pharmacology function】Huang An the AN oxygen Mi Ding be in the Huang An medicine to suppress the germ a very strong kind of the function to synthesize anti-virus medicine, because of it with for germ to synthesize folic acid demand of to ammonia Ji the benzene be sour to have likeness on the structure, exchange with PABA to contend for two hydrogen folic acids to synthesize Mao, bar the germ synthesize two hydrogen folic acids to synthesize Mao, bar the germ synthesize two hydrogen folic acids, end influence nucleic acid protein of synthesize, repress thus germ of growth breed, to variety E-and E+very strongly repress a function.

磺胺间甲氧嘧啶是磺胺类药物中抑菌作用极强的一种合成抗菌药物，因其与细菌合成叶酸时所需要的对氨基苯酸在结构上具有相似性，与PABA兑争二氢叶酸合成酶，阻碍细菌合成二氢叶酸合成酶，阻碍细菌合成二氢叶酸，最终影响核酸蛋白质的合成，从而抑制细菌的生长繁殖，对多种E-及E+有很强的抑制作用。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐