磺胺嘧啶

This experiment was designed to treat 1,015 sick chichens in Kangdi Wanda chicken house by using Toltrazuril and Sulfadimidine. It showed that this two medicine had a 95.07 %( 965/1015) curability. And we also used Monensin, Sulfadimidine, Robenidine , Hydrochloride and Diclazuralto prevent the other 32,485 chikens from being affected this disease.

本实验以康地万达鸡场的33500 只鸡作为研究对象，对1015只患有球虫病的病鸡分别用百球清和磺胺二甲氧嘧啶进行治疗，总治愈率达95.07%（965/1015）；对未发病的32485只鸡分别用莫能菌素、磺胺喹恶琳、氯苯胍、地克珠利进行预防，有效预防率为99.84%。

Sulfa drug derived from pyridine and sulfanilamide.

从嘧啶和磺胺药物中提取的磺胺类药物。

The calibration curve of the SM2-Kit with standard SM2 inhibitor was typical sigmoid curve fitted to the four parameter logistic equation with the linear detection of 0.625 μg/L to 80.0 μg/L (R2=0.9911), the sensitivity of 0.9 μg/L, the IC50 of 5.82 μg/L and the detection limit of 1 μg/L. The recoveries of SM2 spiked in pig feed were 83.4 %, in pig urine were 89.5 %. The precision and accuracy of the assay as determined by inter-assay and intra-assay coefficient variation was both below 15 %. The SM2-Kit generally had 2.08 % cross-reactivity towards sulfamerazine and little or no cross-reactivity towards other sulfonamides. The dilution solution of SM2 had no effect on results of SM2-Kit. The validity of SM2-Kit in 4 ℃ was above six months.

研究结果表明，SM2-Kit的标准曲线呈典型的S型，相关系数R2=0.9911，符合4参数logit曲线拟合，线性检测范围为0.625 μg/L～80 μg/L，灵敏度为0.9 μg/L，半数抑制浓度(IC50)为5.82 μg/L，检测限为1 μg/L；饲料样、猪尿样的平均添加回收率分别为83.4 %、89.5 %，平均批内和批间变异系数均低于15 %；SM2-Kit与磺胺甲基嘧啶的交叉反应率为2.08 %，与其它磺胺类药几乎没有反应性；基质对SM2-Kit的检测结果影响不大；试剂盒在4 ℃可保存6个月。

Objective To study the pH and temperature sensitive properties of sulfamerazine oligomers-polyε-caprolactone-co- DL -lactide-b-ethyleneglycol- b -ε-caprolactone-co-DL-lactide-sulfamerazine oligomers（OSM1-PCLA-PEG-PCLA-OSM1）block copolymer and evaluate sustained release effect of 5-fluorouracil release from the loaded hydrogel in vitro.

摘要目的为嵌段共聚物磺胺甲嘧啶低聚物-聚-ε-己内酯-丙交酯-聚乙二醇-聚-ε-己内酯-丙交酯-磺胺甲嘧啶低聚物（sulfamerazine oligomers-poly(ε-caprolactone-co- DL -lactide-b-ethyleneglycol- b-ε-caprolactone-co-DL-lactide)-sulfamerazine oligomers，OSM1-PCLA-PEG-PCLA-OSM1作为缓控释给药系统的载体提供依据。

Results: The linearity range for the determination was 10~1500 μg/L for sulfanilamide, 50~1500 μg/L for sulfathiazole, 10~1500 μg/L for sulfamethoxazole and 10~1500 μg/L for sulfamethazine.

结果：磺胺、磺胺噻唑、磺胺甲恶唑和磺胺甲嘧啶的线性范围分别是：10~1500μg/L、50~1500μg/L、10~1500μg/L、10~1500μg/L；检出限分别为：8.3、12、7.9、9.1μg/L；回收率为

In the study, N4 -acetyl-sulfamethazine(N4 -ACE-SM2) was synthesized, the determination method of sulfamethazine(SM2) and N4-ACE-SM2 in sturgeon muscle and water were developed, bioconcentration and depuration of SM2 in the sturgeon were completed at last.

本研究合成了磺胺二甲嘧啶(SM_2)的主要代谢产物N~4-乙酰化磺胺二甲嘧啶(N~4-ACE-SM_2)，并建立了SM_2和N~4-ACE-SM_2在鲟鱼肌肉和水中的检测方法，进一步利用流水式鱼类试验，对SM_2在鲟鱼体内的生物富集和生物清除进行了研究。

Three methods are used to prepare molecular imprinted polymers,which include conventional bulk technique or polymerization with ultraviolet initiated in low temperature and polymerization with silica-gel as sacrificial materials. In the polymerization procedure , Sulfamethazine(SM2)and Sulfisoxazole were used as target template molecules, methacrylic acid and 4-vinylpyridine(4-VP) and acrylamide were selected as functional monomers, ethylene glycol dimethacrylate as crosslinker, azobisisobutyronitrile was used as initator.

主要工作如下：首先，以磺胺异噁唑和磺胺二甲嘧啶为模板，分别以4-乙烯基吡啶，甲基丙烯酸，丙烯酰胺为功能单体，以二甲基丙烯酸乙二醇酯为交联剂，偶氮二异丁腈为引发剂，采用了传统方法(60℃恒温水浴)、牺牲硅胶法及低温紫外光聚合法等三种方法合成了一系列的磺胺类药物印迹聚合物。

Drugs (methimazole, methylthiouracil, propylthiouracil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole.

抗甲状腺？药物（他巴唑，甲基硫氧嘧啶，丙基硫氧和硫氧嘧啶）；一些镇静剂（doxylamine琥珀和苯巴比妥），以及包括系统性真菌抗生素灰黄霉素，安体舒通的利尿一些其他药物，以及抗菌磺胺类药物和磺胺二甲嘧啶。

ELISA Kit - chloramphenicol, enrofloxacin, clenbuterol, ractopamine, sulfa "triple play" Sulfadimethoxine, streptomycin, blue ear disease, tylosin, salinomycin Detection Kit; sulfamethazine rapid detection dipstick colloidal gold cards.

ELISA试剂盒—氯霉素、恩诺沙星、克伦特罗、莱克多巴胺、磺胺"三合一"、磺胺二甲氧嘧啶、链霉素、蓝耳病、泰乐菌素、盐霉素检测试剂盒；磺胺二甲嘧啶胶体金快速检测试纸卡等。

Sulfa drugs, such as cotrimoxazole, isoxazole sulfonamides, sulfa Micronesia acridine, Sulfamethoxazole, Sulfonamides methoxy pyrazine, sulfonamides Formamidine, probenecid, double pyrimidine films, bacteriostatic sulfonamide, trimethoprim, sulfathiazole, such as amber.

磺胺类药物，如复方新诺明、磺胺异恶唑、磺胺密啶、磺胺甲基异恶唑、磺胺甲氧吡嗪、磺胺脒、丙磺舒、双嘧啶片、制菌磺、甲氧苄氨嘧啶、琥珀磺胺噻唑等。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐